GEO DataSets

(Submitter supplied) Background: The study of human lacrimal gland biology and development is limited. Lacrimal gland tissue is damaged or poorly functional in a number of disease states including dry eye disease. Development of cell based therapies for lacrimal gland diseases requires a better understanding of the gene expression and signaling pathways in lacrimal gland. Differential gene expression analysis between lacrimal gland and other embryologically similar tissues may be helpful in furthering our understanding of lacrimal gland development. more...

Organism:

Homo sapiens

Type:

Expression profiling by array; Third-party reanalysis

Platforms:

GPL17586 GPL6244

8 Samples

Download data: CEL, TXT, XLS

(Submitter supplied) In humans, the lacrimal gland produces the aqueous component of the tear film, which e.g. moistens and nourishes the ocular surface to maintain ophthalmic health. Decreased production of the aqueous component leads to the development of dry eye disease, which affects over 250 million people worldwide. Despite the impact on patients, the availability of primary human material to study underlying disease mechanisms is severely constrained. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24676

16 Samples

Download data: TSV

(Submitter supplied) Diagnosis of inflamed human lacrimal gland with standard clinical and histopathology evaluation data is imprecise. A large number of these patients are diagnosed with the catch-all classification of nonspecific orbital inflammation (NSOI). We utilized gene expression analysis of lacrimal gland biospy/surgical waste tissues to assist in the classification of sarcoidosis, granulomatosis with polyangiitis (GPA), thyroid eye disease (TED), and subdivisions of NSOI. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

49 Samples

Download data: CEL

(Submitter supplied) Examine the effect of stimulation stress produced by chemical burn to the mice cornea in the lacrimal gland over a time course (0.5 - 360 hours) in comparison with the non-stimulated control animals. Using silver nitrate applicator (silver nitrate 37.5 mg and potassium nitrate 12.5 mg, Graham-Field,Inc.,) do two burns per eye, each with a separate applicator. For animals observed for more than 24 hours, eyes were then treated with gentamicin ointment to minimize infection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS947 GDS948 GDS949

Platforms:

GPL1232 GPL1231 GPL1230

93 Samples

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Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 1 to 360 hour time course in comparison with the non-stimulated controls.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 7 time sets

Platform:

GPL1232

Series:

GSE1393

29 Samples

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Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 0.5 to 24 hour time course in comparison with the non-stimulated controls.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 4 time sets

Platform:

GPL1231

Series:

GSE1393

18 Samples

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Examination of the effect of stimulation stress produced by chemical burn to the cornea in the lacrimal gland over a 0.5 to 360 hour time course in comparison with the non-stimulated controls.

Organism:

Mus musculus

Type:

Expression profiling by array, log ratio, 8 time sets

Platform:

GPL1230

Series:

GSE1393

46 Samples

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(Submitter supplied) Diagnosis of inflamed human orbit tissue with standard clinical and histopathology evaluation data is imprecise. A large number of these patients are diagnosed with the catch-all classification of nonspecific orbital inflammation (NSOI). We utilized gene expression analysis of orbit biopsies to assist in the classification of sarcoidosis, granulomatosis with polyangiitis (GPA), thyroid eye disease (TED), IgG4-associated disease, and subdivisions of NSOI. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

175 Samples

Download data: CEL

(Submitter supplied) PURPOSE: The hypothesis tested in the study was that the effect of estrogen and progesterone on the lacrimal gland is mediated through specific receptors and that hormonal effects involve the regulation of gene expression and protein synthesis. METHODS: Lacrimal glands were collected from young adult, ovariectomized mice, that were treated with 17beta-estradiol, progesterone, 17beta-estradiol plus progesterone or vehicle for 2 weeks. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4277

24 Samples

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(Submitter supplied) Series includes pooled (n = 5 mice per biological replicate) samples from lacrimal, meibomian, and submandibular glands of male palcebo- and testosterone-treated BALB/c mice. All experiments were run in triplicate (pooled biological replicates) on CodeLink Mouse Uniset I Microarrays. Keywords: repeat sample

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1361

Platform:

GPL1310

18 Samples

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Analysis of meibomian glands from orchiectomized BALB/c adults treated with testosterone for 14 days. Androgen deficiency associated with glandular dysfunction and evaporative dry eye. Lacrimal and submandibular glands included. Results suggest pathways regulated by androgens in meibomian glands.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 3 tissue sets

Platform:

GPL1310

Series:

GSE1582

18 Samples

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(Submitter supplied) The Effect of Sex on Lacrimal Gland Gene Expression in the MRL/lpr and Non-obese Diabetic Mouse Models of SjšgrenÕs Syndrome Keywords: Female vs Male Lacrimal Gland Gene Expression.

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL2894 GPL8321

24 Samples

Download data: CEL, TXT

(Submitter supplied) Control rat lacrimal gland samples representing a normal unoperated, a sham, and paired contralateral controls. Experimental LG samples representing paired and unpaired contralateral controls. Paired contralateral control LGs represent LG from the same animal, one side was operated and the other side unoperated. Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS508

Platform:

GPL85

10 Samples

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Analysis of lacrimal gland (LG) 7 days after greater superficial petrosal nerve sectioning. LG ipsilateral to the experimental side, sham operated and unoperated controls included. LG denervation results in severe dry eye like symptoms.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL85

Series:

GSE844

10 Samples

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(Submitter supplied) To analyze the gene expression of mouse embryonic lacrimal gland and its developmental related organs such as harderian gland and eye lid. We performed microarray using them.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

23 Samples

Download data: TXT