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Links from GEO DataSets

Items: 3

1.

LLQR E. coli ATCC 25922 vs wild-type E. coli ATCC 25922

(Submitter supplied) Global response to ciprofloxacin in low level quinolone resistant Escherichia coli: a shorter path to survival. Background: Bactericidal activity of quinolones in bacteria has been related to a combination of DNA fragmentation, ROS production and programmed dead cell systems. Subjacent molecular systems responsible for reduction of bactericidal effect in low-level quinolone resistance (LLQR) phenotypes remain to be clarified. more...
Organism:
Escherichia coli O157:H7 str. Sakai; Escherichia coli O157:H7 str. EDL933; Escherichia coli CFT073; Escherichia coli str. K-12 substr. MG1655; Escherichia coli ATCC 25922
Type:
Expression profiling by array
Platform:
GPL13360
8 Samples
Download data: TXT, XLSX
Series
Accession:
GSE86341
ID:
200086341
2.

Genome-wide screening and characterization of Actinobacillus pleuropneumoniae and its ciprofloxacin-resistant mutants

(Submitter supplied) Understanding constraints which shape antibiotic resistance is key for predicting and controlling drug resistance. Here, we performed high-throughput laboratory evolution of Actinobacillus pleuropneumoniae and its ciprofloxacin resistance-inducing derivatives.This study aims to explore the mechanism of acquired ciprofloxacin resistance in Actinobacillus pleuropneumoniae.
Organism:
Actinobacillus pleuropneumoniae
Type:
Expression profiling by high throughput sequencing
Platform:
GPL30447
6 Samples
Download data: FASTA, GFF3, TXT
Series
Accession:
GSE181030
ID:
200181030
3.

Identification of ciprofloxacin helper drug targets by RNA-seq

(Submitter supplied) The aim of this study was to identify genes that can be targeted by helper drugs to counteract resistance towards ciprofloxacin (CIP). In order to reveal the impact of ciprofloxacin on the transcriptome, differential gene-expression analysis by RNA-seq was performed on the multidrug resistant E. coli strain ST131, treated with a clinically relevant concentration of ciprofloxacin (2 µg/mL).
Organism:
Escherichia coli O25b:H4-ST131
Type:
Expression profiling by high throughput sequencing
Platform:
GPL22638
6 Samples
Download data: TXT, XML
Series
Accession:
GSE89507
ID:
200089507
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Supplemental Content

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