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Links from GEO DataSets

Items: 8

1.

Ectopic expression of miR-625-3p in SW620 colorectal cancer cell lines

(Submitter supplied) Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major medical problem, and predictive markers are urgently needed. Recently, miR-625-3p was reported as a promising predictive marker. Here, we have used in vitro models to show that miR-625-3p functionally induces oxPt resistance in CRC cells, and have identified signalling networks affected by miR-625-3p. The p38 MAPK activator MAP2K6 was shown to be a direct target of miR-625-3p, and, accordingly, was downregulated in patients not responding to oxPt therapy. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16686
6 Samples
Download data: CEL
Series
Accession:
GSE83131
ID:
200083131
2.

RNA profiling in metastatic colorectal cancer patients treated first-line with oxaliplatin

(Submitter supplied) Oxaliplatin (oxPt) resistance in colorectal cancers (CRC) is a major medical problem, and predictive markers are urgently needed. Recently, miR-625-3p was reported as a promising predictive marker. Here, we have used in vitro models to show that miR-625-3p functionally induces oxPt resistance in CRC cells, and have identified signalling networks affected by miR-625-3p. The p38 MAPK activator MAP2K6 was shown to be a direct target of miR-625-3p, and, accordingly, was downregulated in patients not responding to oxPt therapy. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6244
36 Samples
Download data: CEL
Series
Accession:
GSE83129
ID:
200083129
3.

Identify the dysregulated miRNA in human colorectal cancer tissues

(Submitter supplied) Dysregulated miRNA in human colorectal cancer (CRC) were identified through comparison between 4 CRC tumors and their adjacent normal tissues by miRNA array. Histologically-confirmed CRC were included in this study. CRC tissues and paired adjacent normal tissues were obtained from the resected surgical specimens. The adjacent normal tissue is composed of normal colonic mucosa located at approximately 10 cm away from the cancer tissue. more...
Organism:
Homo sapiens
Type:
Expression profiling by RT-PCR
Platform:
GPL16850
8 Samples
Download data: TXT
Series
Accession:
GSE45349
ID:
200045349
4.

A Molecular Profile of Colorectal Cancer to Guide Therapy [PDCCEs]

(Submitter supplied) The ability to dissect heterogeneity in colorectal cancer (CRC) is a critical step in developing predictive biomarkers. The goal of this study was to develop a gene expression based molecular subgrouping model, which predicts the likelihood that patients will respond to specific therapies. Using microarray data compiled from 848 CRC patients, we developed a subgrouping model based on 23 activated oncogenic pathway expression signatures. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL570
133 Samples
Download data: CEL, TXT
Series
Accession:
GSE41568
ID:
200041568
5.

Curcumin mediates oxaliplatin-acquired resistance reversion in colorectal cancer cell lines through modulation of CXC-Chemokine/NF-kB signaling pathway

(Submitter supplied) Resistance to oxaliplatin (OXA) is a complex process affecting the outcomes of metastatic colorectal cancer (CRC) patients treated with this drug. The NF-kBsignalling pathway deregulation has been proposed as an important mechanism involved in this phenomenon. Here, we show that NF-kBwas hyperactivated in in vitro models of OXA-acquired resistance but was attenuated by the addition of Curcumin, a non-toxic NF-kB inhibitor. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL21253
18 Samples
Download data: TXT
Series
Accession:
GSE76092
ID:
200076092
6.

Multiple genes at the chromosome 20q amplicon contribute to colorectal adenoma to carcinoma progression

(Submitter supplied) Chromosomal instability (CIN) is the hallmark of colorectal adenoma to carcinoma progression in 85% of cases, with 20q gain as the most prominent aberration. Yet, the oncogenes at this chromosomal gain are still largely unknown. Here, we aimed to identify oncogenes at 20q involved in colorectal adenoma to carcinoma progression by measuring the effect of 20q gain on gene expression in this amplicon. more...
Organism:
Homo sapiens
Type:
Expression profiling by array; Genome variation profiling by genome tiling array
5 related Platforms
217 Samples
Download data
Series
Accession:
GSE8067
ID:
200008067
7.

Pharmacogenomic Approach for the Identification of Novel Determinants of Resistance to Oxaliplatin in Colon Cancer

(Submitter supplied) Oxaliplatin is a member of the family of Pt-containing chemotherapeutic agents that also include cisplatin (CDDP) and carboplatin. OXA is distinguished from these two older drugs by its different spectrum of activity both in preclinical models and in clinical trials. It is the only platinum analogue to have activity in colon cancer, a disease for which this drug has now become a mainstay of therapy. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL2006
8 Samples
Download data: TXT
Series
Accession:
GSE10405
ID:
200010405
8.

Characterization of an Oxaliplatin Sensitivity Predictor in a preclinical Murine Model of Colorectal Cancer

(Submitter supplied) Despite advances in contemporary chemotherapeutic strategies, long term survival still remains elusive for patients with metastatic colorectal cancer. A better understanding of the molecular markers of drug sensitivity to match therapy with patient is needed to improve clinical outcomes. In this study, we used in vitro drug sensitivity data from the NCI-60 cell lines together with their Affymetrix microarray data to develop a gene expression signature to predict sensitivity to oxaliplatin. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL571
42 Samples
Download data: CEL
Series
Accession:
GSE28691
ID:
200028691
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