Similar studies for GEO DataSets (Select 200071217) - GEO DataSets

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Items: 20

Select item 2000712171.

How C/EBPa creates an elite cell state for reprogramming to pluripotency [RNAseq]

(Submitter supplied) Mouse Bcell, upon ectopic expression of the transcription factor Cebpa for 18h, can be reprogrammed to iPS with extremely high efficiency. To understand the molecular control of this phenomena we performed multiple high throughtput functionnal genomic analysis.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
13 Samples

Download data: BW

Series

Accession:: GSE71217

ID:: 200071217

PubMed Similar studies SRA Run Selector

Select item 2000754812.

How C/EBPa creates an elite cell state for reprogramming to pluripotency [4C]

Organism:: Mus musculus

Type:: Other

Platform:: GPL13112
7 Samples

Download data: BW

Series

Accession:: GSE75481

ID:: 200075481

PubMed Similar studies SRA Run Selector

Select item 2000712183.

How C/EBPa creates an elite cell state for reprogramming to pluripotency

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL19057 GPL13112 GPL10787
68 Samples

Download data: BW, TXT

Series

Accession:: GSE71218

ID:: 200071218

Select item 2000523974.

C/EBPα poises B cells for rapid reprogramming into iPS cells

(Submitter supplied) C/EBPα induces transdifferentiation of B cells into macrophages at high efficiencies and enhances reprogramming into induced pluripotent stem cells (iPSCs) when co-expressed with Oct4, Sox2, Klf4 and Myc (OSKM). However, how C/EBPα accomplishes these effects is unclear. We now found that transient C/EBPα expression followed by OSKM activation induces a 100 fold increase in iPSC reprogramming efficiency, involving 95% of the cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL13112 GPL13912
48 Samples

Download data: BED, TSV, TXT

Series

Accession:: GSE52397

ID:: 200052397

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000523965.

C/EBPα poises B cells for rapid reprogramming into iPS cells [RNA-Seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: TSV

Series

Accession:: GSE52396

ID:: 200052396

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000523736.

C/EBPα poises B cells for rapid reprogramming into iPS cells [ChIP-Seq]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: BED

Series

Accession:: GSE52373

ID:: 200052373

PubMed Similar studies SRA Run Selector

Select item 2000463217.

C/EBPα poises B cells for rapid reprogramming into iPS cells [array]

(Submitter supplied) Somatic cell reprogramming into pluripotent stem cells induced by Oct4, Sox2, Klf4 and Myc (OSKM) occurs at low frequencies and with a considerable delay involving a stochastic phase. In contrast, transdifferentiation of B cells into macrophages induced by C/EBPα is fully efficient and initiated almost immediately. We now discovered that a pulse of C/EBPα in B cell precursors followed by OSKM expression dramatically enhances reprogramming to pluripotency, overcoming the stochastic phase. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
44 Samples

Download data: TXT

Series

Accession:: GSE46321

ID:: 200046321

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000741568.

An integrated systems biology approach identifies positive cofactor 4 as a pluripotency regulatory factor

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL1261
8 Samples

Download data: CEL

Series

Accession:: GSE74156

ID:: 200074156

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Select item 2000741519.

Expression data from three types of spermatogonial stem cells.

(Submitter supplied) Multipotent spermatogonial stem cells (mSSCs) derived from SSCs are a potential new source of individualized pluripotent cells in regenerate medicine such as ESCs. We hypothesized that the culture-induced reprogramming of SSCs was mediated by a mechanism different from that of iPS, and was due to up-regulation of specific pluripotency-related genes during cultivation. Through a comparative analysis of expression profile data, we try to find cell reprogramming candidate factors from mouse spermatogonial stem cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE74151

ID:: 200074151

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007414910.

RNA sequencing analysis in WT and Pc4-OE mESC lines.

(Submitter supplied) Spermatogonial stem cells (SSCs) can spontaneously dedifferentiate into embryonic stem cell (ESC)-like cells, which are designated as multipotent SSCs (mSSCs), without ectopic expression of reprogramming factors. SSCs express key OSKM reprogramming factors at some levels, and do not require ectopic expression of any gene for the acquisition of pluripotency during reprogramming to mSSCs. Therefore, we reasoned that additional factors are required to regulate SSC reprogramming. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
2 Samples

Download data: TXT

Series

Accession:: GSE74149

ID:: 200074149

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005640611.

Global gene expression analyses of paused iPSCs

(Submitter supplied) Low Klf4 expression reproducibly gives rise to a homogeneous population of partially reprogrammed iPSCs. Upregulation of Klf4 allows these cells to resume reprogramming, indicating that they are paused iPSCs that remain on the path towards pluripotency. Paused iPSCs with different Klf4 expression levels remain at distinct intermediate stages of reprogramming.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
24 Samples

Download data: TXT

Series

Accession:: GSE56406

ID:: 200056406

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003782212.

The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL6246 GPL13112
34 Samples

Download data: BED, CEL

Series

Accession:: GSE37822

ID:: 200037822

Select item 20003782113.

The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [ChIP-Seq]

(Submitter supplied) Pluripotency can be induced in somatic cells by ectopic expression of defined transcription factors, however the identity of epigenetic regulators driving the progression of cellular reprogramming requires further investigation. Here we uncover a non-redundant role for the JmjC-domain-containing protein histone H3 methylated Lys 27 (H3K27) demethylase Utx, as a critical regulator for the induction, but not for the maintenance, of primed and naïve pluripotency in mice and in humans. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
27 Samples

Download data: BED

Series

Accession:: GSE37821

ID:: 200037821

PubMed Similar studies SRA Run Selector

Select item 20003577514.

The H3K27 demethylase Utx facilitates somatic and germ cell epigenetic reprogramming to pluripotency [Affymetrix gene expression]

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
7 Samples

Download data: CEL

Series

Accession:: GSE35775

ID:: 200035775

Select item 20014815815.

A PIANO (Proper, Insufficient, Aberrant, and NO reprogramming) response to the Yamanaka factors in the initial stages of human iPSC reprogramming

(Submitter supplied) Yamanaka reprogramming is revolutionary but inefficient, slow and stochastic. The underlying molecular events for these mixed outcomes of iPSC reprogramming is still unclear. Previous studies about transcriptional responses to reprogramming overlooked human reprogramming, and are compromised by the fact that only a rare population proceeds towards pluripotency and a significant amount of the collected transcriptional data may not represent the positive reprogramming. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
13 Samples

Download data: CSV

Series

Accession:: GSE148158

ID:: 200148158

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009564216.

DNA-binding pluripotency factors and DNA demethylases can cooperate to maintain pluripotent stem cell identity even in the absence of Brd4

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
46 Samples

Download data: BW

Series

Accession:: GSE95642

ID:: 200095642

PubMed Full text in PMC Similar studies

Select item 20008876017.

DNA-binding pluripotency factors and DNA demethylases can cooperate to maintain pluripotent stem cell identity even in the absence of Brd4 [RNA-seq]

(Submitter supplied) Histone acetylation and the acetyl-lysine reader Brd4 have recently been implicated in embryonic stem cell (ESC) proliferation and self-renewal. We found that naïve pluripotent ESCs exhibit increased incorporation of glucose-derived carbons onto acetylated histones and elevations in H3K9ac and Brd4 recruitment at pluripotency gene promoters. Surprisingly, both H3K9 acetyltransferases, GCN5 and PCAF, and Brd4 recruitment were dispensable for proliferation, self-renewal and pluripotency of naïve ESCs. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
12 Samples

Download data: TXT

Series

Accession:: GSE88760

ID:: 200088760

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006169418.

MEF_OSK_O_KS_T20

(Submitter supplied) Next Generation Sequencing with differdent pluripotent transcript factor overexpression in MEF Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) by defined factors. The low efficiency of reprogramming limited the potential application of iPSCs. Here we found that knockdown LSD1 , which demethylates histone H3 Lys 4 or 9 , could increase iPSCs generation. It has been reported that LSD1 interaction with Oct4 which is the core factor of reprogramming. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16417
5 Samples

Download data: TXT

Series

Accession:: GSE61694

ID:: 200061694

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005077619.

c-Jun impedes somatic cell reprogramming by activating mesenchymal core regulators and suppressing pluripotent ones

(Submitter supplied) The somatic cell fate can be converted to tumor or pluripotent ones by ectopic expression of transcription factors in vitro and in vivo. Many oncogenic transcription factors are known to mediate both fates as they share similar proliferative and metabolic properties. Paradoxically, we found c-Jun as the first oncogene that appears to specify a somatic fate, oppose the pluripotent one and impede reprogramming. more...