Similar studies for GEO DataSets (Select 200065411) - GEO DataSets

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Items: 20

Select item 2000654111.

Gene expression profiling of preneoplastic K8-creERT2/PIK3CAH1047R mammary subsets

(Submitter supplied) This study examined the effect of mutant PIK3CAH1047R expression in mammary subsets of preneoplastic mammary glands from K8-creERT2/PIK3CA H1047R mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
20 Samples

Download data: CEL

Series

Accession:: GSE65411

ID:: 200065411

Select item 2000598742.

PIK3CA(H1047R)-evoked breast tumorigenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
49 Samples

Download data: CEL

Series

Accession:: GSE59874

ID:: 200059874

Select item 2000598723.

Gene expression profiling of Lgr5-creERT2/PIK3CA H1047R and K8-creERT2/PIK3CA H1047R-evoked mammary tumors

(Submitter supplied) This study examined the gene expression profile of mammary tumors derived from Lgr5- and K8-positive cell-of-origins

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
25 Samples

Download data: CEL

Series

Accession:: GSE59872

ID:: 200059872

Select item 2000598704.

Gene expression profiling of preneoplastic Lgr5-creERT2/PIK3CAH1047R mammary subsets

(Submitter supplied) This study examined the effect of mutant PIK3CAH1047R expression in mammary subsets of preneoplastic mammary glands from Lgr5-creERT2/PIK3CA H1047R mice

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
24 Samples

Download data: CEL

Series

Accession:: GSE59870

ID:: 200059870

Select item 2000408755.

Early parity-induced gene expression in mouse mammary cell subtypes

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profiles of stromal and various epithelial mammary cell subpopulations in mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
35 Samples

Download data: CEL

Series

Accession:: GSE40875

ID:: 200040875

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000692906.

Reactivation of multipotency by oncogenic PIK3CA induces breast tumor heterogeneity

(Submitter supplied) Breast cancer is the most frequent cancer in women and consists of heterogeneous types of tumours that are classified into different histological and molecular subtypes1-3. Pik3ca and p53 are the two most frequently mutated genes and are associated with different types of human breast cancers4. The cellular origin and the mechanisms leading to Pik3ca-induced tumour heterogeneity remain unknown. Here, we used a genetic approach in mice to define the cellular origin of Pik3ca-derived tumours and its impact on tumour heterogeneity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
28 Samples

Download data: CEL

Series

Accession:: GSE69290

ID:: 200069290

Select item 2000759897.

Targeted Pten deletion plus p53-R270H mutation in mouse mammary epithelium induces aggressive claudin-low and basal-like breast cancer

(Submitter supplied) WAP-Cre:Ptenf/f:p53lox.stop.lox_R270H composite mice were generated by genetic crossing. In these mice, Pten is deleted and a R270H p53 mutation in the DNA binding domain is induced upon expression of Cre recombinase in pregnancy-identified alveolar progenitors. Tumors were characterized by histology, marker analysis, various bioinformatics methods, high-throughput (HTP) FDA-drug screen as well as orthotopic injection to quantify tumor initiating cells (TICs) and tail-vein injection to identify lung-metastasis. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
31 Samples

Download data: CEL

Series

Accession:: GSE75989

ID:: 200075989

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000756488.

RNA-Seq of Lgr6 positive and negative cells in mouse mammary gland

(Submitter supplied) Lgr6-positive cells have been shown to label stem/progenitors cells in several tissues including tongue and skin. However their role in mammary gland has never been investigated. Here we used Lgr6-eGFP-IRES-CreER2 mice to isolate and characterize Lgr6-positive population in mammary gland of 5-week old female mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
4 Samples

Download data: TXT

Series

Accession:: GSE75648

ID:: 200075648

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001103519.

Early lineage segregation of multipotent embryonic mammary gland progenitors [RNA-Seq II]

(Submitter supplied) We report single cell RNA-seq data that reveals that Embryonic Multipotent Progenitors (EMPs) in the mammary gland express a unique hybrid basal and luminal signature associated with the different adult lineages.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
384 Samples

Download data: CSV

Series

Accession:: GSE110351

ID:: 200110351

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010971110.

Early lineage segregation of multipotent embryonic mammary gland progenitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL11180 GPL24247
399 Samples

Download data: CEL

Series

Accession:: GSE109711

ID:: 200109711

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20010970711.

Early lineage segregation of multipotent embryonic mammary gland progenitors [RNA-seq I]

(Submitter supplied) The mammary gland (MG) is composed of basal cells (BCs) and luminal cells (LCs). While it is generally believed that MG arises from embryonic multipotent progenitors (EMPs), it remains unclear when lineage restriction occurs and what are the mechanisms responsible for the switch from multipotency to unipotency during MG morphogenesis. Here, we performed multicolor lineage tracing and assessed the fate of single progenitors and demonstrated the existence of a developmental switch from multipotency to unipotency during embryonic MG development. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: TXT

Series

Accession:: GSE109707

ID:: 200109707

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010930612.

Early lineage segregation of multipotent embryonic mammary gland progenitors [expression]

(Submitter supplied) The mammary gland (MG) is composed of basal cells (BCs) and luminal cells (LCs). While it is generally believed that MG arises from embryonic multipotent progenitors (EMPs), it remains unclear when lineage restriction occurs and what are the mechanisms responsible for the switch from multipotency to unipotency during MG morphogenesis. Here, we performed multicolor lineage tracing and assessed the fate of single embryonic progenitors during mouse MG development. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
7 Samples

Download data: CEL

Series

Accession:: GSE109306

ID:: 200109306

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009943313.

p63 regulates the switch from multipotency to unipotency during embryonic MG development

(Submitter supplied) The mammary gland (MG) is composed of basal cells (BCs) and luminal cells (LCs). While it is generally believed that MG arises from embryonic multipotent progenitors (EMPs), it remains unclear when lineage restriction occurs and what are the mechanisms responsible for the switch from multipotency to unipotency during MG morphogenesis. Here, we performed multicolor lineage tracing and assessed the fate of single embryonic progenitors during mouse MG development. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
3 Samples

Download data: CEL

Series

Accession:: GSE99433

ID:: 200099433

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015867714.

Single cell transcriptomics reveals involution mimicry during the specification of the basal breast cancer subtype

(Submitter supplied) Here, we use spatially and time controlled induction of Elf5 within the mammary epithelium in the context of the luminal MMTV-PyMT mouse mammary cancer to study tumour progression mechanisms associated to the specification of the basal breast cancer subtype at single-cell resolution.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
11 Samples

Download data: MTX, TSV

Series

Accession:: GSE158677

ID:: 200158677

PubMed Similar studies SRA Run Selector

Select item 20009287715.

Regulation of mammary luminal cell differentiation and tumorigenesis by p38α

(Submitter supplied) Mammary stem and progenitor cells are essential for mammary gland homeostasis and are also candidates for cells of origin of mammary tumors. Here, we provide evidence that the protein kinase p38a is required for the differentiation of luminal progenitor cells through modulation of the transcription factors Runx1 and Foxa1. Moreover, using a mouse model for breast cancer initiated by luminal cells, we show that p38a downregulation in mammary epithelial cells reduces tumorigenesis, which correlates with reduced numbers of tumor-initiating cells. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
16 Samples

Download data: CEL

Series

Accession:: GSE92877

ID:: 200092877

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Select item 20014994916.

Characterization of estrogen, progesterone and the endocrine-disrupting chemical-induced mouse mammary gland reorganization via single-cell RNA-sequencing

(Submitter supplied) The mammary epithlium goes through the drastic reorganization during development, pregnancy, and menopause as well as by external hormones and its mimicry, which risks the gland for the specific type of breast cancer. Using a surgical menopausal (ovariectomized) mouse model, we assessed how mammary gland tissue was affected by 17β-estradiol (E2), progesterone (P4) and polybrominated diphenyl ethers (PBDEs). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
5 Samples

Download data: MTX, TSV

Series

Accession:: GSE149949

ID:: 200149949

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007749817.

Induced loss of p53 in mammary luminal cells leads to their clonal expansion and facilitates development of mammary tumours with loss of luminal identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome variation profiling by SNP array

Platforms:: GPL16570 GPL13147
22 Samples

Download data: CEL

Series

Accession:: GSE77498

ID:: 200077498

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007749718.

Affymetrix SNP array data for Trp53-null mammary tumors developed in a mouse model with a K8+ luminal cell origin

Organism:: Mus musculus

Type:: Genome variation profiling by SNP array

Platform:: GPL13147
6 Samples

Download data: CEL, TXT

Series

Accession:: GSE77497

ID:: 200077497

PubMed Full text in PMC Similar studies

Select item 20007749619.

Microarray expression profiling data for Trp53-null mammary epithelial cells and tumors from a mouse model with a K8+ luminal cell origin

(Submitter supplied) Mammary epithelium is hierarchically organized, with multipotent basal mammary stem cells (MaSCs) producing both luminal and basal cells during development or upon transplantation. Recent studies suggested that most breast cancers might originate from luminal cells, and oncogenic events, such as ectopic expression of PIK3CAH1047R, could induce multipotency in committed luminal cells. p53 is the most commonly mutated gene in human breast cancer; in particular, its inactivating mutations are found in most triple-negative breast cancers, raising a question as to whether p53-loss plays a key role in acquisition of MaSC-like properties by luminal cells. more...