Similar studies for GEO DataSets (Select 200062229) - GEO DataSets

Select item 2000622291.

Interphase condensins regulate ligand-depedent enhancer activation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
47 Samples

Download data: BIGWIG

Series

Accession:: GSE62229

ID:: 200062229

PubMed Full text in PMC Similar studies

Select item 2001419882.

The dual function of JmjC domain-containing protein KDM5C in both gene transcriptional activation and repression promotes breast cancer cell growth and tumorigenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL20795 GPL21290 GPL20301
18 Samples

Download data: BIGWIG

Series

Accession:: GSE141988

ID:: 200141988

PubMed Full text in PMC Similar studies

Select item 2001419873.

The dual function of JmjC domain-containing protein KDM5C in both gene transcriptional activation and repression promotes breast cancer cell growth and tumorigenesis [RNA-seq]

(Submitter supplied) Emerging evidence suggested that epigenetic regulators can exhibit both co-activator and co-repressor activities in gene transcriptional regulation and disease development, such as cancer. However, how these dual activities are regulated and coordinated in cellular contexts remains elusive. Here, we reported that KDM5C, a repressive histone demethylase, is unexpectedly required for estrogen/estrogen receptor alpha (ERa)-induced gene transcriptional activation to promote cell proliferation, while it suppresses the expression of type I interferons (IFNs) and interferon-stimulated genes (ISGs) to escape from immuno-surveillance. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20301 GPL21290
8 Samples

Download data: BIGWIG

Series

Accession:: GSE141987

ID:: 200141987

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001419864.

The dual function of JmjC domain-containing protein KDM5C in both gene transcriptional activation and repression promotes breast cancer cell growth and tumorigenesis [ChIP-seq]

(Submitter supplied) Emerging evidence suggested that epigenetic regulators can exhibit both co-activator and co-repressor activities in gene transcriptional regulation and disease development, such as cancer. However, how these dual activities are regulated and coordinated in cellular contexts remains elusive. Here, we reported that KDM5C, a repressive histone demethylase, is unexpectedly required for estrogen/estrogen receptor alpha (ERa)-induced gene transcriptional activation to promote cell proliferation, while it suppresses the expression of type I interferons (IFNs) and interferon-stimulated genes (ISGs) to escape from immuno-surveillance. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL20795 GPL20301
10 Samples

Download data: BIGWIG

Series

Accession:: GSE141986

ID:: 200141986

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000622285.

Interphase condensins regulate ligand-depedent enhancer activation (GRO-seq)

(Submitter supplied) An emerging theme of gene regulation is the involvement of architectural chromosomal molecules in transcription control. Condensins are critical regulators of mitotic chromosomes, but their interphase chromatin localization and functions remain poorly understood. Here we report that both the condensin I and condensin II complexes exhibit an unexpected, dramatic 17-?-estradiol-induced preferential recruitment to oestrogen receptor ? (ER-?)-bound active enhancers in interphase breast cancer cells, exhibiting non-canonical interaction with ER-? distinct from classic cofactors. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
8 Samples

Download data: BIGWIG

Series

Accession:: GSE62228

ID:: 200062228

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000622226.

Interphase condensins regulate ligand-depedent enhancer activation (ChIP-seq)

(Submitter supplied) An emerging theme of gene regulation is the involvement of architectural chromosomal molecules in transcription control. Condensins are critical regulators of mitotic chromosomes, but their interphase chromatin localization and functions remain poorly understood. Here we report that both the condensin I and condensin II complexes exhibit an unexpected, dramatic 17-β-estradiol-induced preferential recruitment to oestrogen receptor α (ER-α)-bound active enhancers in interphase breast cancer cells, exhibiting non-canonical interaction with ER-α distinct from classic cofactors. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
39 Samples

Download data: BIGWIG

Series

Accession:: GSE62222

ID:: 200062222

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000456787.

Genome-wide distribution of the three condensin complexes in C. elegans

(Submitter supplied) Condensins are multi-subunit protein complexes that regulate chromosome structure throughout cell-cycle. Metazoans contain two types of condensin complexes (I and II) with essential and distinct functions. In C. elegans a third type of condensin (IDC) functions as part of the X chromosome dosage compensation complex1,2. We mapped genome-wide binding sites of the three condensin types in C. elegans embryos. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13657 GPL13776
92 Samples

Download data: BED, TXT, WIG

Series

Accession:: GSE45678

ID:: 200045678

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001256098.

A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL21290
47 Samples

Download data: BW

Series

Accession:: GSE125609

ID:: 200125609

PubMed Full text in PMC Similar studies

Select item 2001256079.

A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer [GRO-seq]

(Submitter supplied) Estrogen and estrogen receptor alpha (ERα) signaling plays an essential role in ERα-positive breast cancer. ERα mainly occupies on distal enhancers within genome and requires the cooperation of additional co-factors to tune the enhancer activity. Through in vivo proximity-dependent labeling technique BioID, we identified YAP1 and TEAD4 protein as novel co-regulators of ERα. YAP and TEAD are nuclear effectors of the Hippo pathway regulating cell proliferation, organ size and tumorigenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
6 Samples

Download data: BW

Series

Accession:: GSE125607

ID:: 200125607

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20012560610.

A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer [RNA-seq]

(Submitter supplied) Estrogen and estrogen receptor alpha (ERα) signaling plays an essential role in ERα-positive breast cancer. ERα mainly occupies on distal enhancers within genome and requires the cooperation of additional co-factors to tune the enhancer activity. Through in vivo proximity-dependent labeling technique BioID, we identified YAP1 and TEAD4 protein as novel co-regulators of ERα. YAP and TEAD are nuclear effectors of the Hippo pathway regulating cell proliferation, organ size and tumorigenesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
12 Samples

Download data: TXT

Series

Accession:: GSE125606

ID:: 200125606

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20012559411.

A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer [ChIP-seq]

(Submitter supplied) Estrogen and estrogen receptor alpha (ERα) signaling plays an essential role in ERα-positive breast cancer. ERα mainly occupies on distal enhancers within genome and requires the cooperation of additional co-factors to tune the enhancer activity. Through in vivo proximity-dependent labeling technique BioID, we identified YAP1 and TEAD4 protein as novel co-regulators of ERα. YAP and TEAD are nuclear effectors of the Hippo pathway regulating cell proliferation, organ size and tumorigenesis. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21290
29 Samples

Download data: BW

Series

Accession:: GSE125594

ID:: 200125594

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007489212.

Condensin plays a role in both interphase nuclei and premature chromosome condensation

(Submitter supplied) Purpose: to identify how condensin I removal affects gene expression globally. Methods: Chicken DT40 CAP-H KO cells were treated with or without dox for 36 h. Total RNA samples were extracted and subjected to sequencing using an Illumina Hiseq2000 platform. Library preparation and Illumina sequencing were performed by Macrogen (South Korea). The sequence tags were spliced-mapped onto the chicken genome galGal4 using Tophat and Bowtie2 following quality test using FASTQC. more...

Organism:: Gallus gallus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16133
5 Samples

Download data: TXT

Series

Accession:: GSE74892

ID:: 200074892

PubMed Similar studies SRA Run Selector

Select item 20007395813.

Target Gene Repression Based on Dismissal of Polymerase II from Estrogen Receptor Trans-bound Enhancers Is Associated With Clinical Outcome in Human Breast Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Keywords: Genome binding/occupancy profiling by high throughput sequencing

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
48 Samples

Download data: BIGWIG

Series

Accession:: GSE73958

ID:: 200073958

PubMed Full text in PMC Similar studies

Select item 20007395714.

Target Gene Repression Based on Dismissal of Polymerase II from Estrogen Receptor Trans-bound Enhancers Is Associated With Clinical Outcome in Human Breast Cancer [GRO-seq]

(Submitter supplied) We find that 17-β-estradiol (E2)-bound estrogen receptor α (ERα) is bound in trans to a cohort of FOXA1-dependent, constitutively activate enhancers, inactivating these enhancers by decommissioning/removing enhancer Polymerase II (Pol II), despite recruitment of coactivators. This is based on the surprising recruitment by the ERα DNA binding domain of the histone demethylase, KDM2A, which, functioning independently of its demethylase function. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
14 Samples

Download data: BIGWIG

Series

Accession:: GSE73957

ID:: 200073957

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20007395615.

Target Gene Repression Based on Dismissal of Polymerase II from Estrogen Receptor Trans-bound Enhancers Is Associated With Clinical Outcome in Human Breast Cancer [ChIP-seq]

(Submitter supplied) We find that 17-β-estradiol (E2)-bound estrogen receptor α (ERα) is bound in trans to a cohort of FOXA1-dependent, constitutively activate enhancers, inactivating these enhancers by decommissioning/removing enhancer Polymerase II (Pol II), despite recruitment of coactivators. This is based on the surprising recruitment by the ERα DNA binding domain of the histone demethylase, KDM2A, which, functioning independently of its demethylase function. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16791
34 Samples

Download data: BIGWIG

Series

Accession:: GSE73956

ID:: 200073956

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011756916.

Analysis of the Phosphorylated Estrogen Receptor-α Cistrome Reveals Association with Direct ER-DNA Binding and the Transcription Factor GRHL2

(Submitter supplied) Phosphorylation of the estrogen receptor-α (ER) at serine 118 (pS118-ER) is involved in modulating ER-dependent gene transcription and recruitment of ER to certain gene promoters. While the effects of pS118 on ER-DNA interactions have been investigated at specific sites, the genome-wide binding profile (cistrome) of pS118-ER remains to be studied. To characterize the pS118-ER cistrome, ChIP-seq was performed on pS118-ER and pan-ER in MCF-7 cells. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
25 Samples

Download data: BED, BEDGRAPH

Series

Accession:: GSE117569

ID:: 200117569

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009512317.

Priming and Activation of ERα Enhancers Through Ordered and Cooperative Interactions Between p300 and Mediator

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL18573
103 Samples

Download data

Series

Accession:: GSE95123

ID:: 200095123

PubMed Full text in PMC Similar studies

Select item 20009512218.

Priming and Activation of ERα Enhancers Through Ordered and Cooperative Interactions Between p300 and Mediator [GRO-seq]

(Submitter supplied) Estrogen receptors alpha (ERα) converges estrogen signaling by orchestrating estrogen (E2)-dependent transcription regulation. Upon binding to the chromatin, ERα serves as a nucleation site for de novo formation of transcription enhancer complexes. Steroid receptor coactivators family proteins (SRCs, a.k.a p160) and Mediator complex are the two coregulators for ERα that directly interact with the receptors and control enhancer activity by regulating recruitment of other coregulators and transcription machinery. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: BW

Series

Accession:: GSE95122

ID:: 200095122

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20009512119.

Priming and Activation of ERα Enhancers Through Ordered and Cooperative Interactions Between p300 and Mediator [ChIP-seq]

(Submitter supplied) Estrogen receptors alpha (ERα) converges estrogen signaling by orchestrating estrogen (E2)-dependent transcription regulation. Upon binding to the chromatin, ERα serves as a nucleation site for de novo formation of transcription enhancer complexes. Steroid receptor coactivators family proteins (SRCs, a.k.a p160) and Mediator complex are the two coregulators for ERα that directly interact with the receptors and control enhancer activity by regulating recruitment of other coregulators and transcription machinery. more...