Similar studies for GEO DataSets (Select 200054976) - GEO DataSets

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Items: 20

Select item 2000549761.

Gene expression in thymi of Tcf1 -/-, Tcf +/- or Tcf1 -/- mice with tumor.

(Submitter supplied) The HMG-box factor Tcf1 is required during T-cell development in the thymus and mediates the nuclear response to Wnt signals. Tcf1−/− mice have previously been characterized and show developmental blocks at the CD4−CD8− double negative (DN) to CD4+CD8+ double positive transition. Due to the blocks in T-cell development, Tcf1−/− mice normally have a very small thymus. Unexpectedly, a large proportion of Tcf1−/− mice spontaneously develop thymic lymphomas with 50% of mice developing a thymic lymphoma/leukemia at the age of 16 wk. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4867
Platform:: GPL1261
17 Samples

Download data: CEL

Series

Accession:: GSE54976

ID:: 200054976

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 48672.

T-cell factor 1-deficient thymic lymphoma

Analysis of thymocytes collected from Tcf1-/- animals with thymic lymphoma. Tcf1-/- animals of similar age without tumors and Tcf1+/- animals were also examined. Tcf1 is a Wnt-responsive transcription factor. Results provide insight into the role of Tcf1 in the development of thymic lymphomas.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 tissue sets

Platform:: GPL1261
Series:: GSE54976
17 Samples

Download data: CEL

DataSet

Accession:: GDS4867

ID:: 4867

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001248233.

Genome-wide mapping of Lef1 occupancy in conventional CD4+ T cells

(Submitter supplied) Determine genome-wide binding locations by Lef1 in conventional CD4+ T cells

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: BED

Series

Accession:: GSE124823

ID:: 200124823

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001197694.

Impact of Tcf1/Lef1 deficiency on Treg cells

(Submitter supplied) Comparison of transcriptome between control and Tcf1/Lef1-deficient Treg cells

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: WIG, XLSX

Series

Accession:: GSE119769

ID:: 200119769

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001197685.

Genome-wide mapping of Tcf1 occupancy in conventional and regulatory CD4+ T cells

(Submitter supplied) Determine genome-wide binding locations by Tcf1 in conventional and regulatory CD4+ T cells

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
3 Samples

Download data: BED

Series

Accession:: GSE119768

ID:: 200119768

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001647136.

Tcf1/Lef1 transcription factors and CD8 T cell identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:: GPL13112 GPL17021 GPL21103
26 Samples

Download data: HIC

Series

Accession:: GSE164713

ID:: 200164713

PubMed Full text in PMC Similar studies

Select item 2001647127.

Tcf1/Lef1 transcription factors and CD8 T cell identity [RNA-seq]

(Submitter supplied) Comparison of transcriptomes between WT and Tcf1/Lef1-deficient naïve CD8+ T cells

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: DIFF

Series

Accession:: GSE164712

ID:: 200164712

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001647118.

Tcf1/Lef1 transcription factors and CD8 T cell identity [H3K27ac ChIP-seq]

(Submitter supplied) Comparison of H3K27ac profiles ibetween WT and Tcf1/Lef1-deficient naïve CD8+ T cells

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13112 GPL21103
9 Samples

Download data: BED

Series

Accession:: GSE164711

ID:: 200164711

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001647109.

Tcf1/Lef1 transcription factors and CD8 T cell identity [Hi-C]

(Submitter supplied) Comparison of global genome organization between WT and Tcf1/Lef1-deficient naïve CD8+ T cells

Organism:: Mus musculus

Type:: Other

Platform:: GPL21103
4 Samples

Download data: HIC

Series

Accession:: GSE164710

ID:: 200164710

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016468910.

Tcf1/Lef1 transcription factors and CD8 T cell identity [DNAase-seq]

(Submitter supplied) Comparison of chromatin accessibility profiles between WT and Tcf1/Lef1-deficient naïve CD8+ T cells

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
5 Samples

Download data: XLS

Series

Accession:: GSE164689

ID:: 200164689

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016467011.

Tcf1/Lef1 transcription factors and CD8 T cell identity [ChIP-seq]

(Submitter supplied) Determine genome-wide binding locations by Tcf1 in naive CD8+ T cells

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
2 Samples

Download data: XLS

Series

Accession:: GSE164670

ID:: 200164670

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007324012.

Tcf1 and Lef1 establish CD8+ T cell identity via their intrinsic histone deacetylase activity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
23 Samples

Download data: BED, WIG

Series

Accession:: GSE73240

ID:: 200073240

PubMed Full text in PMC Similar studies

Select item 20007323913.

Impact of Tcf1 and Lef1 deficiency on histone marks and Tcf1 binding in CD8 T cells

(Submitter supplied) Comparison of epigenome and Tcf1 occupancy between control and Tcf1/Lef1-deficient CD8 T cells

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL13112
17 Samples

Download data: BED

Series

Accession:: GSE73239

ID:: 200073239

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007323814.

Impact of Tcf1 and Lef1 deficiency on mature CD8 thymocytes

(Submitter supplied) Comparison of transcriptome between control and Tcf1/Lef1-deficient mature CD8 thymocytes

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: WIG, XLS

Series

Accession:: GSE73238

ID:: 200073238

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007308415.

Sp5 and Sp8 recruit b-catenin to the Tcf1-Lef1 enhanceosome to activate Wnt target gene transcription

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11002 GPL13112
16 Samples

Download data

Series

Accession:: GSE73084

ID:: 200073084

PubMed Full text in PMC Similar studies

Select item 20007308316.

Determination of the Lef1 regulated tanscriptome in differentiating ES cells

(Submitter supplied) Lef1 is a critical transducer of the Wnt/beta-catenin signaling pathway that is essential for mesoderm differentiation in vertebrate embryos. We established a doxycycline inducible ES cell line to over-express Flag-tagged Lef1 in differentiating ES cells which have the capacity to form mesoderm cells in vitro. The goal of this study was to identify the genes/gene networks regulated by Lef1 to understand how it regulates mesoderm differentiation and to establish the Lef1-regulated, Wnt/beta-catenin transcriptome.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE73083

ID:: 200073083

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007308217.

Determination of the Sp5 regulated transcriptome in differentiating ES cells

(Submitter supplied) Sp5 is a target and critical transducer of the Wnt/beta-catenin signaling pathway and is essential for mesoderm differentiation in vertebrate embryos. We established a doxycycline inducible ES cell line to over-express Flag epitope-tagged Sp5 protein in differentiating ES cells which have the capacity to form mesoderm cells in vitro. The goal of this study was to identify the genes/gene networks regulated by Sp5 to understand how it regulates mesoderm differentiation by identifying important target genes which may mediate its activity.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: TXT

Series

Accession:: GSE73082

ID:: 200073082

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007298918.

Genome-wide binding profiles of Sp5 in differentiation mouse embryonic stem cells

(Submitter supplied) We have determined the genome-wide binding profile of the transcription factor Sp5. Flag-tagged Sp5 was targeted to the HPRT locus in A2Lox.cre ES cells to allow for Doxycycline inducible expression. ES cells were cultured as embryoid bodies for 2 days to prime them for germ layer differentiation. Cells were then treated with Doxycycline for 24 hrs. We found that Flag-Sp5 prefentially bound to promoters associatd with several growth factor signalling pathways, but most prominently with the Wnt/beta-catenin pathway to selectively promote mesoderm differentiation over neural. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
4 Samples

Download data: BED

Series

Accession:: GSE72989

ID:: 200072989

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009232319.

Requirements for different Tcf1 isoforms in T cell development

(Submitter supplied) Comparison of transcriptome between control, Tcf1 long isoform (p45)-deficient, complete Tcf1-deficient DN3 thymoctyes

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: CSV

Series

Accession:: GSE92323

ID:: 200092323

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003329220.

Expression data from WT DN3, TCF-1-deficient DN3 thymocytes, and T cell lymphomas in TCF-1-deficient animals.

(Submitter supplied) TCF-1 is an HMG family transcription factor which is known to be critical for T cell development. We discovered that it has a unique role in suppressing malignant transformation of developing thymocytes at early stages. We identified ID2 and LEF-1 as key TCF-1 target genens in tumor suppression. We used microarrays to detect gene expression changes in WT and TCF-1 deficient DN3 thymocytes as well as T cell lymphoma cells developed in TCF-1 KO mice.