GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL13112

80 Samples

Download data

(Submitter supplied) Aims: Epidemiological and animal studies have shown that maternal diet can influence metabolism in adult offspring. However, the molecular mechanisms underlying these changes remain poorly understood. Here, we aim to explore phenotypes induced by maternal obesity in a mouse model and examine gene expression and epigenetic alterations in adulthood induced by maternal diet. Methods: We analyzed genetically identical male mice born from dams fed a high- or low-fat diet throughout pregnancy and until day 21 postpartum. more...

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL13112

40 Samples

Download data: TXT

(Submitter supplied) Aims: Epidemiological and animal studies have shown that maternal diet can influence metabolism in adult offspring. However, the molecular mechanisms underlying these changes remain poorly understood. Here, we aim to explore phenotypes induced by maternal obesity in a mouse model and examine gene expression and epigenetic alterations in adulthood induced by maternal diet. Methods: We analyzed genetically identical male mice born from dams fed a high- or low-fat diet throughout pregnancy and until day 21 postpartum. more...

Organism:

Mus musculus

Type:

Methylation profiling by high throughput sequencing

Platform:

GPL13112

40 Samples

Download data: TXT

(Submitter supplied) Note: non-normalized values and associated raw data cannot be located by the submitter This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

236 Samples

Download data

(Submitter supplied) The aim of this study is to characterize transcriptional changes induced by maternal diet in several adult tissues and to test whether differences in DNA methylation or microRNA expression could explain these changes. -------------------------- Note: non-normalized values and associated raw data cannot be located by the submitter

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

40 Samples

Download data

(Submitter supplied) The aim of this study is to characterize transcriptional changes induced by maternal diet in several adult tissues and to test whether differences in DNA methylation or microRNA expression could explain these changes. -------------------------- Note: non-normalized values and associated raw data cannot be located by the submitter

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

40 Samples

Download data

(Submitter supplied) The aim of this study is to characterize transcriptional changes induced by maternal diet in several adult tissues and to test whether differences in DNA methylation or microRNA expression could explain these changes. -------------------------- Note: non-normalized values and associated raw data cannot be located by the submitter

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

40 Samples

Download data

(Submitter supplied) The aim of this study is to characterize transcriptional changes induced by maternal diet in several adult tissues and to test whether differences in DNA methylation or microRNA expression could explain these changes. -------------------------- Note: non-normalized values and associated raw data cannot be located by the submitter

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

36 Samples

Download data

(Submitter supplied) The aim of this study is to characterize transcriptional changes induced by maternal diet in several adult tissues and to test whether differences in DNA methylation or microRNA expression could explain these changes. -------------------------- Note: non-normalized values and associated raw data cannot be located by the submitter

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

40 Samples

Download data

(Submitter supplied) The aim of this study is to characterize transcriptional changes induced by maternal diet in several adult tissues and to test whether differences in DNA methylation or microRNA expression could explain these changes. -------------------------- Note: non-normalized values and associated raw data cannot be located by the submitter

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

40 Samples

Download data

(Submitter supplied) Maternal diet is associated with the development of metabolism-related and other non-communicable diseases in offspring. Underlying mechanisms, functional profiles, and molecular markers are only starting to be revealed. Here, we explored the physiological and molecular impact of maternal Western-style diet on the liver of male and female offspring. C57BL/6 dams were exposed to either a low fat/low cholesterol diet (LFD) or a Western-style high fat/high cholesterol diet (WSD) for six weeks before mating, as well as during gestation and lactation. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4774

Platform:

GPL11533

27 Samples

Download data: CEL

Analysis of livers from PD14 offspring of C57BL/6 dams fed a Western-style high fat/high cholesterol diet (WSD). Maternal diet is associated with the development of metabolism-related diseases in offspring. Results provide insight into molecular impact of maternal WSD on male and female offspring.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 gender, 2 protocol sets

Platform:

GPL11533

Series:

GSE46359

27 Samples

Download data: CEL

(Submitter supplied) Background: Consumption of high fat diets has negative impacts on health and well-being, some of which may be epigenetically regulated. Selenium and folate are two compounds which influence epigenetic mechanisms. We investigated the hypothesis that post-weaning supplementation with adequate levels of selenium and folate in mouse offspring fed a high fat, low selenium and folate diet during gestation and lactation will lead to epigenetic changes of potential importance for long-term health. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

24 Samples

Download data: TXT

(Submitter supplied) Maternal high-fat consumption has negative effects on the offspring’s obesity/diabetes susceptibility and we hypothesize that epigenetic modifications in the skeletal muscle are partly responsible for this phenotype. To detect genes affected by maternal nutrition, offspring of low-fat (LF) and high-fat (HF) diet fed dams (C57BL/6 mice) received LF diet upon weaning and were sacrificed at an age of 6 or 25 weeks. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21810

20 Samples

Download data: TXT

(Submitter supplied) We have previously reported that providing a control diet to obese and diabetic mice during the periconceptional/gestation/lactation period, led to a drastic sex-specific shift from susceptibility to resistance to high fat feeding (HFD) in the female offspring. In the present study, we aimed to characterize exhaustively the metabolic phenotype of F1 and F2 sensitive (S1, S2) and resistant (R1, R2) mice and underscore in the liver, muscle and adipose tissue, the transcriptional and epigenetic mechanisms supporting the response to HFD, the trait of resistance/susceptibility and the adaptation across generations. more...

Organism:

Mus musculus; Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL13688

19 Samples

Download data: GPR, TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Methylation profiling by genome tiling array; Expression profiling by high throughput sequencing

Platforms:

GPL15887 GPL14602 GPL7060

13 Samples

Download data: PAIR

(Submitter supplied) Slimming is globally prevalent especially in young women, and it may contribute to the metabolic health of their offspring. Whereas some Lamarckian ideas about environmental inheritance have been dismissed, increasing evidence suggest that certain acquired traits can be transmitted to the next generation. It is therefore of great interest to determine how and to what extent a maternal lifestyle change contributes to their offspring. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL14602

2 Samples

Download data: TXT

(Submitter supplied) Slimming is globally prevalent especially in young women, and it may contribute to the metabolic health of their offspring. Whereas some Lamarckian ideas about environmental inheritance have been dismissed, increasing evidence suggest that certain acquired traits can be transmitted to the next generation. It is therefore of great interest to determine how and to what extent a maternal lifestyle change contributes to their offspring. more...

Organism:

Mus musculus

Type:

Methylation profiling by genome tiling array

Platform:

GPL7060

2 Samples

Download data: PAIR

(Submitter supplied) Slimming is globally prevalent especially in young women, and it may contribute to the metabolic health of their offspring. Whereas some Lamarckian ideas about environmental inheritance have been dismissed, increasing evidence suggest that certain acquired traits can be transmitted to the next generation. It is therefore of great interest to determine how and to what extent a maternal lifestyle change contributes to their offspring. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL15887

9 Samples

Download data: PAIR

(Submitter supplied) The present study aimed to examine the effect of high-fat diet prior to pregnancy on the liver of mouse offspring. Female C57BL/6J mice were fed a normal chow (15.2% fat by energy) (CTR and CTR-PP groups) or a high-fat chow (31.2% fat by energy) (HFD and HFD-PP groups) for 3−4 weeks and then mated with male C57BL/6J mice fed normal chow. Some mothers continued on the same diet until pups reached 21 days of age (CTR and HFD), and others were fed the different chows from gestational day 0 (CTR-PP and HFD-PP) to determine the effects of a high-fat diet during the pre-pregnancy period in HFD-PP/CTR and HFD/CTR-PP comparisons.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL13912

10 Samples

Download data: CSV