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Links from GEO DataSets

Items: 20

1.

∆Np63 regulates stem cell activity in mammary gland development

(Submitter supplied) MaSC, luminal progenitor enriched subpopulations and total MECs as well, were isolated from both wild type and ∆Np63 KO heterozygous mouse and the transcriptome profiles were determined and compared.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
6 Samples
Download data: TXT
Series
Accession:
GSE47417
ID:
200047417
2.

ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signaling

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
20 Samples
Download data: TXT
Series
Accession:
GSE47493
ID:
200047493
3.

Transcriptome profiles of mouse mammary stem cells and progenitor cells

(Submitter supplied) MaSC, Luminal progenitor enriched subpopulations were isolated from virgin and pregnant mice based on using both surface marker or internal reporter transgene (GFP) expression. (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035), and the transcirptome profiles were determined and compared.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
14 Samples
Download data: TXT
Series
Accession:
GSE47419
ID:
200047419
4.

Transcriptome characterization of IFNa response in MaSC and luminal progenitor cells

(Submitter supplied) Transcriptome response to IFNa treatment in MaSC, Luminal progenitor cells were studied. The MaSC, Luminal progenitor cells enriched subpopulations were sorted based on CD24/CD29 expression from mammary epithelial cells of virgin female mice . (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035). The cells were cultured in mammosphere condition in vitro and treated with Ifna for 8 days. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
8 Samples
Download data: TXT
Series
Accession:
GSE93068
ID:
200093068
5.

miR-199a-LCOR axis regulation of mammary gland stem cell and breast cancer stem cell transcriptional programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus; Homo sapiens
Type:
Expression profiling by array; Non-coding RNA profiling by array
5 related Platforms
46 Samples
Download data: TXT
Series
Accession:
GSE85808
ID:
200085808
6.

LCOR regulates transcription of human mammary epithelial and breast cancer cells

(Submitter supplied) Normal human mammary epithelial cell (HMLE) and breast cancer MDA-MB-231 cells are engineered to knockdown or enforce expression of variety of LCOR gene products. In addition to wild-type cDNA, functional domain deficient mutants were used to elucidate mechanism of LCOR incorporated transcriptional regulation. The transcriptome profiles were determined and compared.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL17077
12 Samples
Download data: TXT
Series
Accession:
GSE85802
ID:
200085802
7.

Transcriptome profiles of mouse mammary stem cells and progenitor cells 2

(Submitter supplied) MaSC, Luminal progenitor enriched subpopulations were sorted based on CD24/CD29 expression from mammary epithelial cells of virgin female mice . (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035), and the transcirptome profiles were determined and compared.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL7202
10 Samples
Download data: TXT
Series
Accession:
GSE85635
ID:
200085635
8.

microRNA profiles of mouse mammary stem cells and luminal cells

(Submitter supplied) MaSC and luminal enriched subpopulations were sorted based on CD24/CD29 expression from mammary epithelial cells of virgin female mice . (Tiede BJ et al., 2009, PLoS ONE 4(11): e8035. doi:10.1371/journal.pone.0008035), and the microRNA profiles were determined using microRNA array and compared.
Organism:
Mus musculus
Type:
Non-coding RNA profiling by array
Platform:
GPL17912
6 Samples
Download data: TXT
Series
Accession:
GSE85634
ID:
200085634
9.

Transcriptome characterization of the mouse Lgr5+_MaSCs

(Submitter supplied) Lgr5 positive and negative MaSC enriched P4 subpopulation were isolated from virgin Lgr5-EGFP-IRES-CreERT2 mice. The transcriptome profiles of the cells are compared to elucidate the molecular mechanism Lgr5+_MaSCs as a more defined MaSCs subpopulation within the P4 (MaSC and basal progenitor enriched popuation).
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL10787
6 Samples
Download data: TXT
Series
Accession:
GSE85633
ID:
200085633
10.

miR-199a regulates human mammary epthelial cell function

(Submitter supplied) miR-199a expression was enforced in HMLE cells using lentiviral vector pLEX. The transcriptome profiles changes following miR-199a expression was studied.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL6480
4 Samples
Download data: TXT
Series
Accession:
GSE85629
ID:
200085629
11.

A high proportion of myoepithelial cells have mammary stem cell potential

(Submitter supplied) The basal cell lineage in the mouse mammary gland is perceived to be composed mostly of differentiated myoepithelial cells intermixed with a rare subpopulation of mammary stem cells. Here, we show that a high proportion (~30%) of basal cells have colony forming capacity when actin-myosin contraction is prevented. A basal cell subpopulation enriched for mammary repopulating units (MRUs) is shown to be enriched for dividing cells. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6887
12 Samples
Download data: TXT
Series
Accession:
GSE31347
ID:
200031347
12.

Expression data from sorted control and Pygo2-null mouse mammary stem/basal cells

(Submitter supplied) Skin-mammary specific knockout (SSKO) of Pygo2 (K14-cre; Pygo2 flox/-) , a WNT signaling co-activator, results in defective mouse mammary gland development. The FACS sorted mammary stem cell (MaSC)/basal population from Pygo2 SSKO mammary gland displays biased differentiation towards luminal/alveolar lineage in vitro, and reduced regeneration rate of new mammary gland in vivo
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
10 Samples
Download data: CEL
Series
Accession:
GSE45826
ID:
200045826
13.

Early parity-induced gene expression in total mammary epithelial cells and mammary cell subtypes in mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
43 Samples
Download data: CEL
Series
Accession:
GSE40877
ID:
200040877
14.

Early parity-induced gene expression in total mammary epithelial cells in mice

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profile of total isolated mammary epithelial cells in mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
8 Samples
Download data: CEL
Series
Accession:
GSE40876
ID:
200040876
15.

Early parity-induced gene expression in mouse mammary cell subtypes

(Submitter supplied) This study examined the effect of early pregnancy on the gene expression profiles of stromal and various epithelial mammary cell subpopulations in mice.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
35 Samples
Download data: CEL
Series
Accession:
GSE40875
ID:
200040875
16.

MiR-34a controls proliferation and plasticity of early-progenitors in the normal mammary gland and in breast cancer

(Submitter supplied) The miR-34 is a tumor-suppressor miRNA family involved in various human cancers, including breast. However, the role of such miRNAs in the control of mammary stem cells (MaSCs), early-progenitors and their tumor counterparts, (CSCs) lies largely unexplored. Here, we identified miR-34a as directly regulated by TP53 in primary mouse mammospheres. Expression of miR-34a is induced upon luminal commitment and differentiation and able to inhibit the expansion of the MaSCs/early-progenitor pool in a p53-independent fashion. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13112
12 Samples
Download data: XLSX
Series
Accession:
GSE99401
ID:
200099401
17.

Gene signature of adult mammary stem cells and mammary cancer stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR; Expression profiling by array
Platforms:
GPL1261 GPL2850
41 Samples
Download data: CEL
Series
Accession:
GSE40715
ID:
200040715
18.

Gene signature of adult mammary stem cells and mammary cancer stem cells (RT_PCR)

(Submitter supplied) The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-negative breast cancer in man. The MaCSCs are capable of recapitulating tumorigenesis when transplanted at low multiplicities in vivo, and of forming self-renewing organoids in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by RT-PCR
Platform:
GPL2850
17 Samples
Download data: TXT
Series
Accession:
GSE40704
ID:
200040704
19.

Gene signature of adult mammary stem cells and mammary cancer stem cells (Affymetrix)

(Submitter supplied) The Wnt/beta-catenin signalling pathway plays a central role in mammary stem cell homeostasis and in breast cancer. We employed the CD29hiCD24+ cell surface antigens to identify a subpopulation of mammary CSCs from Apc1572T/+, a mouse model for metaplastic breast adenocarcinoma, a subtype of triple-negative breast cancer in man. The MaCSCs are capable of recapitulating tumorigenesis when transplanted at low multiplicities in vivo, and of forming self-renewing organoids in vitro. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL1261
24 Samples
Download data: CEL
Series
Accession:
GSE40702
ID:
200040702
20.

Characterization of Cell Lines Derived from Breast Cancers and Normal Mammary Tissues for the Study of the Intrinsic Molecular Subtypes

(Submitter supplied) Five molecular subtypes (Luminal A/B, HER2-enriched, Basal-like, and Claudin-low) with clinical implications have been identified. In this report, we evaluated molecular and phenotypic relationships of a large in vitro panel of human breast cancer cell lines (BCCLs), human mammary fibroblasts (HMFs) and human mammary epithelial cells (HMECs) with (1) breast tumors, (2) normal breast cell-enriched subpopulations and (3) human embryonic stem cells (hESCs) and bone marrow-derived mesenchymal stem cells (hMSC). more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL7504
105 Samples
Download data
Series
Accession:
GSE50470
ID:
200050470
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