Similar studies for GEO DataSets (Select 200044327) - GEO DataSets

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Items: 20

Select item 2000443271.

The hypoxia-inducible transcription factor ZNF395 is controlled by I-kappaB kinase and activates genes involved in the innate immune response and cancer

(Submitter supplied) Activation of the hypoxia inducible transcription factor HIF-alpha and the NF-kappaB pathway promotes inflammation mediated tumor progression. The cellular transcription factor ZNF395 was repeatedly found over expressed in various human cancers and particularly in response to hypoxia, implying a functional relevance. To understand the biological activity of ZNF395, we identified target genes of ZNF395 by a genome-wide expression screen. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS5381
Platform:: GPL6244
8 Samples

Download data: CEL

Series

Accession:: GSE44327

ID:: 200044327

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 53812.

Transcription factor ZNF395 effect on RTS3b skin cancer cell line

Analysis of skin cancer cell line RTS3b-TR-ZNF395 following doxycycline-induced expression of FLAG-tagged ZNF395. Transcription factor ZNF395 is overexpressed in various human cancers, often in response to hypoxia. Results provide insight into the molecular effects of ZNF395 in skin cancer cells.

Organism:: Homo sapiens

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL6244
Series:: GSE44327
8 Samples

Download data: CEL

DataSet

Accession:: GDS5381

ID:: 5381

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2001370653.

RNA-seq Transcriptome Analysis of AD169 and AD169-ΔUL26 infected MRC5 fibroblasts.

(Submitter supplied) We employed RNA-seq to map the transcriptome of human MRC5 fibroblasts during HCMV infection with AD169 and AD169-ΔUL26 strains. These data will highlight the ways in which the HCMV UL26 protein alters host gene transcripton during infection.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT, XLSX

Series

Accession:: GSE137065

ID:: 200137065

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000339134.

IKK-epsilon regulates the balance between the type I and type II interferon responses

(Submitter supplied) Virus infection induces the production of type I and type II interferons (IFN-I and IFN-II), cytokines that mediate the antiviral response. IFN-I (IFN-a and -b) induces the assembly of ISGF3 (interferon-stimulated gene factor 3), a multimeric transcriptional activation complex comprised of STAT1, STAT2 and IRF9. IFN-II (IFN-g) induces the homodimerization of STAT1 to form the GAF (gamma-activated factor) complex. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
12 Samples

Download data: BED

Series

Accession:: GSE33913

ID:: 200033913

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000569505.

Regulatory consequences of TARBP2 knock-down in MDA-LM2-shDicer cell-line

(Submitter supplied) siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE56950

ID:: 200056950

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000569496.

Regulatory consequences of TARBP2 knock-down in Dicer-null MEFs

(Submitter supplied) siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6885
5 Samples

Download data: TXT

Series

Accession:: GSE56949

ID:: 200056949

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000569487.

Regulatory consequences of TARBP2 over-expression in MDA-231 cell-line

(Submitter supplied) Transient transfection of TARBP2 expression vectors (along with GFP controls) followed by transcriptomic profiling revealed that over-expression of TARBP2 resulted in a significant enrichment of sRSE-carrying transcripts among the down-regulated transcripts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE56948

ID:: 200056948

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000569478.

Regulatory consequences of TARBP2 knock-down in CN-LM1a cell-line

(Submitter supplied) siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE56947

ID:: 200056947

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000569459.

Regulatory consequences of TARBP2 knock-down in293T cell-line

(Submitter supplied) siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
3 Samples

Download data: TXT

Series

Accession:: GSE56945

ID:: 200056945

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004964910.

Metastasis-suppressor transcript destabilization through TARBP2 binding of mRNA hairpins

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL10558 GPL6885 GPL11154
78 Samples

Download data

Series

Accession:: GSE49649

ID:: 200049649

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004964811.

TARBP2 HITS-CLIP

(Submitter supplied) In order to identify TARBP2 binding sites on endogenous RNA, we performed HITS-CLIP on a myc-tagged TARBP2 expressing cell-line (transient transfection)

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
2 Samples

Download data: BED

Series

Accession:: GSE49648

ID:: 200049648

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20004961312.

Regulatory consequences of ZNF395 knock-down in MDA-LM2-shTARBP2 cell-line

(Submitter supplied) shRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of ZNF395 resulted in a significant up-regulation in several key oncogenes.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE49613

ID:: 200049613

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004961213.

Regulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line [stability experiment]

(Submitter supplied) siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant increase in the stability of sRSE-carrying transcripts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
8 Samples

Download data: TXT

Series

Accession:: GSE49612

ID:: 200049612

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004961114.

Regulatory consequences of TARBP2 knock-down in MDA-LM2 cell-line

(Submitter supplied) siRNA-mediated knock-down followed by transcriptomic profiling revealed that silencing of TARBP2 resulted in a significant up-regulation of sRSE-carrying transcripts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE49611

ID:: 200049611

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004960915.

In-culture titration experiment for sRSE

(Submitter supplied) In order to test the transcriptome-wide functionality of the identified sRSE instances, we performed an in vivo titration experiment in which synthetic RNA oligonucleotides harboring tandem sRSE1 repeats were used as intracellular decoys that would bind the putative trans factor, preventing it from targeting endogenous transcripts.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE49609

ID:: 200049609

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004960816.

Differential transcript stability measurements in MDA-MB-231 vs. MDA-LM2 cells

(Submitter supplied) We performed whole-genome stability measurements for MDA-MB-231 and its highly metastatic derivative MDA-LM2. Our goal was to identify post-transcriptonal regulons that are deregulated en route to higher metastatic capacity.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
32 Samples

Download data: TXT

Series

Accession:: GSE49608

ID:: 200049608

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20019658217.

The transcriptomic analysis for Usp18 homozygous depletion in established AML1/ETO 9a leukemia mouse model [AE9a_scRNA-seq II]

(Submitter supplied) Usp18 is a potent negative reguator of type I IFN signaling. However, it is not well characterized how Usp18 affects IFN stimulated genes (ISGs) induction in AML in mouse model. Here, we analyzed the transcriptomic data when combined with homozygous depletion of USP18, which phenotypicaly reduce AE9a leukemia progression.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21103
2 Samples

Download data: MTX, TSV

Series

Accession:: GSE196582

ID:: 200196582

PubMed Full text in PMC Similar studies

Select item 20019658118.

The transcriptomic analysis for Usp18 heterozygous depletion in established AML1/ETO 9a leukemia mouse model [AE9a_RNA-seq II]

(Submitter supplied) Usp18 is a potent negative reguator of type I IFN signaling. However, it is not well characterized how Usp18 affects IFN stimulated genes (ISGs) induction in AML in mouse model. Here, we analyzed the transcriptomic data when combined with heterozygous depletion of USP18, which phenotypicaly reduce AE9a leukemia progression.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
6 Samples

Download data: CSV

Series

Accession:: GSE196581

ID:: 200196581

PubMed Full text in PMC Similar studies

Select item 20019658019.

The ATAC analysis for Usp18 heterozygous depletion in established AML1/ETO 9a leukemia mouse model

(Submitter supplied) Type I IFN induces IFN stimulated genes (ISGs) and exert varieties of immunomoduratory functions. However, it is not well characterized how ISGs are regulated by negative regulators of IFN signaling. Here, we analyzed the chromatin accessibility when combined with depletion of USP18, one of major negative regulators for IFN signaling.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21103
6 Samples

Download data: TXT

Series

Accession:: GSE196580

ID:: 200196580

PubMed Full text in PMC Similar studies

Select item 20016542920.

Type I interferon (IFN) response in USP18 knockout in MDA-MB-231 breast cancer cells [RNA-seq]

(Submitter supplied) Type I IFN induces IFN stimulated genes (ISGs) and exert varieties of immunomoduratory functions. However, it is not well characterized how ISGs are regulated by negative regulators of IFN signaling. Here, we analyzed the transcriptomic change when combined with depletion of USP18, one of major negative regulators for IFN signaling.