Similar studies for GEO DataSets (Select 200041130) - GEO DataSets

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Items: 20

Select item 2000411301.

Expression profiling of Low-Risk Myelodysplastic Syndromes (MDSs)

(Submitter supplied) Genome-wide expression and methylation profiling identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes (MDSs). Gene expression profiling signatures may be used to classify the subtypes of Myelodysplastic syndrome (MDS) patients. However, there are few reports on the global methylation status in MDS. The integration of genome-wide epigenetic regulatory marks with gene expression levels would provide additional information regarding the biological differences between MDS and healthy controls. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16100
25 Samples

Download data: CEL

Series

Accession:: GSE41130

ID:: 200041130

Select item 2000412162.

Genome-wide profiling of methylation identifies novel targets with aberrant hypermethylation and reduced expression in low-risk myelodysplastic syndromes.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL16100 GPL2040
45 Samples

Download data: CEL, GPR

Series

Accession:: GSE41216

ID:: 200041216

Select item 2000412153.

Methylation profiling of Low-Risk Myelodysplastic Syndromes (MDSs)

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL2040
20 Samples

Download data: GPR

Series

Accession:: GSE41215

ID:: 200041215

Select item 2000517584.

Genome-wide profiling of DNA methylation and expression identifies CIMP in myelodysplastic syndrome [Illumina]

(Submitter supplied) To identify genes hypermethylated and transcriptionally downregulated, we have employed the Illumina Infinium HumanMethylation450 BeadChip and Agilent SurePrint G3 Human Gene Expression 8x60K. And we validated selected genes in cases and controls. eventually we estalished CIMP of MDS.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL13534
8 Samples

Download data: TXT

Series

Accession:: GSE51758

ID:: 200051758

Select item 2000040095.

Methylation profiling of leukemia cell lines

(Submitter supplied) Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor-suppressor genes. We developed a novel and robust technique that allows the unbiased, genome wide detection of CpG-methylation in limited DNA samples, without applying methylation-sensitive restriction endonucleases or bisulfite-treatment. The approach is based on a recombinant, methyl-CpG binding protein that efficiently binds CpG-methylated DNA depending on its degree of CpG methylation. more...

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL2040
10 Samples

Download data

Series

Accession:: GSE4009

ID:: 200004009

Select item 2000032806.

Expression profiling of leukemia cell lines

(Submitter supplied) Methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor-suppressor genes. Genome wide methylation profiling of myeloid leukemia cell lines identified a large number of genes with aberrantly methylated CpG islands. Comparative mRNA expression analysis suggests that more than half of these genes show extremely low or absent expression in normal cells, suggesting that hypermethylation in cancer may be independent of the transcriptional status of the affected gene. more...

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Dataset:: GDS2251
Platform:: GPL570
4 Samples

Download data

Series

Accession:: GSE3280

ID:: 200003280

Select item 22517.

Myeloid leukemia cell lines

Comparison of myeloid leukemia cells to normal monocytes. Transcriptional status of each gene compared to its CpG methylation state. The methylation of CpG islands is associated with transcriptional repression and, in cancer, leads to the abnormal silencing of tumor suppressor genes.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 cell line, 2 disease state sets

Platform:: GPL570
Series:: GSE3280
4 Samples

Download data

DataSet

Accession:: GDS2251

ID:: 2251

Select item 2000194298.

Expression data from bone marrow CD34+ cells of MDS patients and healthy controls

(Submitter supplied) In order to gain insight into the molecular pathogenesis of the myelodysplastic syndromes (MDS), we performed global gene expression profiling and pathway analysis on the hematopoietic stem cells (HSC) of 183 MDS patients as compared with the HSC of 17 healthy controls. The most significantly deregulated pathways in MDS include interferon signaling, thrombopoietin signaling and the Wnt pathway. Among the most significantly deregulated gene pathways in early MDS are immunodeficiency, apoptosis and chemokine signaling, whereas advanced MDS is characterized by deregulation of DNA damage response and checkpoint pathways. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3795
Platform:: GPL570
200 Samples

Download data: CEL

Series

Accession:: GSE19429

ID:: 200019429

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 37959.

Myelodysplastic syndrome: CD34+ hematopoietic stem cells

Analysis of bone marrow CD34+ hematopoietic stem cells of myelodysplastic syndrome (MDS) patients. MDS is a group of clonal hematopoietic stem cell malignancies characterized by ineffective hematopoiesis. Results provide insight into the molecular pathogenesis of MDS.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state, 5 specimen sets

Platform:: GPL570
Series:: GSE19429
200 Samples

Download data: CEL

DataSet

Accession:: GDS3795

ID:: 3795

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20003526310.

Methylation in breast cancer vs. normal tissue

(Submitter supplied) We applied a combination of Methyl-CpG Immunoprecipitation (MCIp) and Human CpG Island microarrays to identify aberrant DNA methylation in eight low-grade breast invasive carcinomas and two pre-invasive breast tumors against ten normal breast tissues.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL9767
10 Samples

Download data: TXT

Series

Accession:: GSE35263

ID:: 200035263

Select item 20002631911.

Epigenome analysis of normal and cancer tissues in prostate cancer

(Submitter supplied) Genome wide DNA methylation profiling of normal and cancer tissue samples in prostate cancer. The Illumina Infinium 27k Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 27,000 CpGs. Samples are pool of 12 normal and 12 cancer tissues.

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
2 Samples

Download data: TXT

Series

Accession:: GSE26319

ID:: 200026319

Select item 20003582412.

Genome-wide DNA methylation study in bladder cancer

(Submitter supplied) Genome-wide DNA methylation profiles were determined on a set of fresh 44 bladder cancer tissues using normal blood as control. DNA amplicons were prepared using Differential Methylation Hybridization (DMH) method, subsequently hybridized on to the Agilent Human CpG island Microarray. The goal was to unravel the DNA methylation patterns in different subgropus of bladder cancer along with finding markers for progresssion and early diagnosis.

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL4126
44 Samples

Download data: TXT

Series

Accession:: GSE35824

ID:: 200035824

Select item 20003401113.

Expression data from mouse intestine: BALB/c MTHFR+/+ on control diet vs BALB/c MTHFR+/- on folate deficient diet

(Submitter supplied) Previous studies in our laboratory have shown that low folate diet (control diet with 2mg folate/kg, low folate diet with 0.3mg folate/kg) can induce intestinal tumors in BALB/c mice. We used microarrays to compare MTHFR+/+ BALB/c mice fed control diet and MTHFR+/- BALB/c mice fed low folate diet.

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5377
Platform:: GPL6246
8 Samples

Download data: CEL

Series

Accession:: GSE34011

ID:: 200034011

Select item 537714.

Folate deficiency effect on methylenetetrahydrofolate reductase MTHFR+/- intestinal neoplasia model: duodenum

Analysis of intestine from MTHFR+/- BALB/c mice fed a low folate diet (0.3mg/kg) for 1 yr. The MTHFR C677T polymorphism is associated with risk for colorectal cancer. Results provide insight into mechanisms underlying the impact of folate and MTHFR deficiency on tumorigenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:: GPL6246
Series:: GSE34011
8 Samples

Download data: CEL

DataSet

Accession:: GDS5377

ID:: 5377

Select item 20002698215.

Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by array

Platforms:: GPL8490 GPL6244
39 Samples

Download data: CEL, CHP

Series

Accession:: GSE26982

ID:: 200026982

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002697416.

Sperm DNA methylation

(Submitter supplied) BACKGROUND: In previous studies using candidate gene approaches, low sperm count (oligospermia) has been associated with altered sperm mRNA content and DNA methylation in both imprinted and non-imprinted genes. We performed a genome-wide analysis of sperm DNA methylation and mRNA content to test for associations with sperm function. METHODS AND RESULTS: Sperm DNA and mRNA were isolated from 21 men with a range of semen parameters presenting to a tertiary male reproductive health clinic. more...

Organism:: Homo sapiens

Type:: Methylation profiling by array

Platform:: GPL8490
21 Samples

Download data: TXT

Series

Accession:: GSE26974

ID:: 200026974

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002688117.

mRNA Content of Human Sperm

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
18 Samples

Download data: CEL, CHP

Series

Accession:: GSE26881

ID:: 200026881

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003969218.

NHD13 vs wild type LK cells

(Submitter supplied) Investigation of differences in gene expression between NHD13 mice with myelodysplastic syndrome and wild type littermates.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
6 Samples

Download data: TXT

Series

Accession:: GSE39692

ID:: 200039692

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20007293419.

Dysregulated gene expression pathways in mice models of HR-MDS and AML post MDS mimic human disease

(Submitter supplied) In spite of the recent discovery of genetic mutations in most MDS, pathophysiology of those disorders remain poorly known, and few animal are available. We performed global exome specific gene expression profiling and functional pathway analysis in purified Sca1+ spleen cells of two MDS transgenic mouse models developed by our group. Those models mimic high-risk MDS (HR MDS) and AML post MDS, depending on the transgene promoters used (MRP8NRASD12/tethBCL-2 and MRP8NRASD12/MRP8hBCL-2 respectively). more...