GEO DataSets

(Submitter supplied) ß-chloroprene (2-chloro-1,3-butadiene), a monomer used in the production of neoprene elastomers, is of regulatory interest due to the production of multi-organ tumors in mouse and rat cancer bioassays. A significant increase in female mouse lung tumors was observed at the lowest exposure concentration of 12.8 ppm while a small, but not statistically significant, increase was observed in female rats only at the highest exposure concentration of 80 ppm. more...

Organism:

Rattus norvegicus; Mus musculus

Type:

Expression profiling by array

Datasets:

GDS4847 GDS4848

Platforms:

GPL1355 GPL1261

100 Samples

Download data: CEL

Analysis of lungs of F344 females exposed to 0 to 200 ppm chloroprene (CR) for 5 or 15 days. CR, a monomer used in the production of neoprene elastomers, generates multiorgan tumors in mouse and rat cancer bioassays. Compared to mice (GDS4847), F344 rats are insensitive to CR-induced lung tumors.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 5 dose, 2 time sets

Platform:

GPL1355

Series:

GSE40795

50 Samples

Download data: CEL

Analysis of lungs of B6C3F1 females exposed to 0 to 90 ppm chloroprene (CR) for 5 or 15 days. CR, a monomer used in the production of neoprene elastomers, generates multiorgan tumors in mouse and rat cancer bioassays. Compared to rats (GDS4848), B6C3F1 mice are sensitive to CR-induced lung tumors.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 5 dose, 2 time sets

Platform:

GPL1261

Series:

GSE40795

50 Samples

Download data: CEL

(Submitter supplied) Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures (two years) in mice and rats and costing $2 to $4 million per chemical. Since there are approximately 80,000 chemicals registered for commercial use in the United States and 2,000 more are added each year, applying animal bioassays to all chemicals of concern is clearly impossible. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

242 Samples

Download data: CEL, CHP