Similar studies for GEO DataSets (Select 200036066) - GEO DataSets

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Items: 2

Select item 2000360661.

Factor VII activating protease (FSAP) exerts antifibrotic effects in a mouse model of experimental liver fibrosis

(Submitter supplied) Background and Rationale: Factor VII activating protease (FSAP) is a circulating serine protease produced in the liver. A single nucleotide polymorphism (G534E, Marburg I, MI-SNP) in the gene encoding FSAP (HABP2) leads to lower enzymatic activity and is associated with enhanced liver fibrosis. FSAP is activated by damaged cells and its substrates include growth factors and haemostasis proteins. We have investigated the progression of liver fibrosis in FSAP deficient mice. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11202
12 Samples

Download data: TXT

Series

Accession:: GSE36066

ID:: 200036066

Select item 2000139922.

c-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice

(Submitter supplied) The HGF/c-Met system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been demonstrated in acute liver regeneration its cell specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determined yet. In order to better characterize the role of c-Met in hepatocytes we generated a hepatocyte-specific c-Met knockout mouse (c-Met∆hepa) using the Cre-loxP system and studied its relevance after bile-duct ligation. more...