GEO DataSets

(Submitter supplied) Primary hyperparathyroidism is a common endocrine disorder frequently affecting postmenopausal women. In this study we have investigated expression of the prolactin receptor (PRLr) in a panel of 37 sporadic parathyroid tumours, as well as functionality in vitro in cultured parathyroid tumour cells. High levels of the prolactin receptor gene (PRLR) transcripts were demonstrated in parathyroid tissues as compared to other reference tissues and breast cancer cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL11532

16 Samples

Download data: CEL, CHP

(Submitter supplied) Pancreatic islets adapt to insulin resistance of pregnancy by up regulating beta-cell proliferation and increase insulin secretion. Previously, we found that prolactin receptor (Prlr) signaling is important for this process, as heterozygous prolactin receptor-null (Prlr+/-) mice are glucose intolerant, had a lower number of beta cells and lower serum insulin levels than wild type mice during pregnancy. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21626

7 Samples

Download data: TXT

(Submitter supplied) Changes in gene expression in the infundibulum after a prolonged prolactin treatment (3 μg/h/mouse, 7 days, subcutaneous Alzet osmotic minipump) showed prolactin down regulation of genes necessary for cilium development and function. Collectively, these results suggest that prolactin regulates cyclic changes in ciliated cell function in the infundibulum. They also suggest an additional mechanism whereby prolonged prolactin elevation would negatively impact fertility.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

10 Samples

Download data: XLSX