Similar studies for GEO DataSets (Select 200027960) - GEO DataSets

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Items: 2

Select item 2000279601.

Sensing prokaryotic mRNA signifies microbial viability and promotes immunity

(Submitter supplied) MyD88-independent signal transduction associated with Toll-like receptors (TLRs) 3 and TLR4 is mediated through the adapter protein TRIF (TIR-domain-containing adapter-inducing interferon-beta). It has been proposed that TLR signalling is important for the transcription of crucial inflammasome components like NLRP3, a process that has been termed "priming". In order to test whether TRIF signalling was required for the priming of inflammasome components, we performed a genome wide transcriptional analysis on wild-type and Trif-knockout bone marrow derived macrophages (BMMs) before and 1, 3 and 6 hours after phagocytosis of E. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11533
24 Samples

Download data: CEL

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Accession:: GSE27960

ID:: 200027960

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001024442.

Staphylococcus aureus evades macrophage killing through NLRP3 dependent effects on mitochondrial trafficking

(Submitter supplied) Respiratory innate immunity requires alveolar macrophages, which are specifically targeted by the S. aureus toxin alpha toxin. These data compare the response of alveolar macrophages to S. aureus with or without alpha toxin neutralization.