GEO DataSets

(Submitter supplied) The goal of this study is to investigate the molecular mechanism of lhx1 on regulation of pronephros formation during the early embryonic development. In the vertebrate embryo the kidney is derived from the intermediate mesoderm. The LIM-class homeobox transcription factor lhx1 is expressed early in the intermediate mesoderm and is one of the first genes to be expressed in the nephric mesenchyme. The animal cap cells can be induced by treatment of activin and retinoic acid to differentiate into pronephros tissue. more...

Organism:

Xenopus laevis

Type:

Expression profiling by array

Platform:

GPL1318

12 Samples

Download data: CEL, CHP

(Submitter supplied) The transcriptional events driving specification of the kidney field have been well characterized. However, it remains unknown how the initial field size is established, patterned, and proportioned. Lhx1 is a transcription factor expressed in the kidney anlage and is required for specification of the kidney field, but few Lhx1 interacting cofactors or downstream targets have been identified. By tandem-affinity purification, we isolated Furry (FRY), a multifunctional protein that acts as a transcriptional co-repressor of microRNAs. more...

Organism:

Xenopus laevis

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL14834

3 Samples

Download data: XLS

(Submitter supplied) This study was performed to identify miRNAs that are differentially regulated during mouse kidney development. Two stages (E14.5 and P1) were analyzed. Differential expression was verified using qPCR and/or in situ hybridization.

Organism:

Homo sapiens; Mus musculus; Rattus norvegicus

Type:

Non-coding RNA profiling by array

Platform:

GPL6350

3 Samples

Download data: TXT

(Submitter supplied) Embryos were injected with either control or Activin antisense morpholino oligonucleotides and harvested at Stage 10.5 for RNA analysis. Keywords: Knock-down analysis

Organism:

Xenopus laevis; Xenopus tropicalis

Type:

Expression profiling by array

Platform:

GPL3728

6 Samples

Download data: GPR

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:

GPL13112 GPL17543

24 Samples

Download data: IDAT

(Submitter supplied) Development of the embryonic head is driven by the activity of gene regulatory networks of transcription factors. LHX1 is a homeobox transcription factor that plays an essential role in the formation of the embryonic head. The loss of Lhx1 function results in anterior truncation of the embryo caused by the disruption of morphogenetic movement of tissue precursors and the dysregulation of WNT signaling activity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL17543

12 Samples

Download data: CSV, IDAT

(Submitter supplied) Development of the embryonic head is driven by the activity of gene regulatory networks of transcription factors. LHX1 is a homeobox transcription factor that plays an essential role in the formation of the embryonic head. The loss of Lhx1 function results in anterior truncation of the embryo caused by the disruption of morphogenetic movement of tissue precursors and the dysregulation of WNT signaling activity. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

12 Samples

Download data: CSV

(Submitter supplied) In Xenopus, establishment of the anterior-posterior axis involves two key signalling pathways, canonical Wnt and Nodal-related TGF-β. There are also a number of transcription factors that feedback upon these pathways. The homeodomain protein Hex, an early marker of anterior positional information, acts as a transcriptional repressor suppressing induction and propagation of the Spemman organiser while specifying anterior identity. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

44 Samples

Download data

(Submitter supplied) Pronephric explants were dissected in the presence or absence of hedgehog signaling. Targets from pooled biological samples were examined in triplicate and the expression profiles were determined using Affymetrix Xenopus Genechip 1 arrays. Keywords: repeat

Organism:

Xenopus laevis

Type:

Expression profiling by array

Dataset:

GDS2567

Platform:

GPL1318

6 Samples

Download data

Analysis of pronephric explants dissected from embryos previously injected with banded hedgehog mRNA. Hedgehog suppresses the development of the pronephric kidney tubule but not that of the pronephric glomus. Results provide insight into the molecular basis of this inhibitory effect.

Organism:

Xenopus laevis

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL1318

Series:

GSE3712

6 Samples

Download data

(Submitter supplied) We sequenced mRNA from zebrafish wild-type embryos, gata5 morphants, gata6 morphants, and gata5/6 morphants at bud and 6-somite developmental stages to identify genes co-operatively regulated by gata5 and gata6 during cardiomyocyte progenitor specification.

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL15583

16 Samples

Download data: TSV

(Submitter supplied) A conserved molecular pathway has emerged controlling endoderm formation in Xenopus zebrafish and mice. Key genes in this pathway include Nodal ligands and transcription factors of the Mix-like paired homeodomain class, Gata4-6 zinc finger factors and Sox17 HMG domain proteins. While a linear epistatic pathway has been proposed, the precise hierarchical relationships between these factors and their downstream targets are largely unresolved. more...

Organism:

Xenopus laevis

Type:

Expression profiling by array

Dataset:

GDS2016

Platform:

GPL1318

31 Samples

Download data: CEL, TXT

Analysis of stage 11 embryos inactivated for Nodal signaling, or depleted of Mixer or Sox17 proteins. Microdissected animal caps and vegetal and equatorial regions of stage 11 embryos also examined. Nodal, Mixer, and Sox17 are key proteins of a pathway controlling endoderm formation.

Organism:

Xenopus laevis

Type:

Expression profiling by array, count, 3 development stage, 8 tissue sets

Platform:

GPL1318

Series:

GSE4448

31 Samples

Download data: CEL