GEO DataSets

(Submitter supplied) A fundamental issue in cell biology is how migratory cell behaviors are controlled by dynamically regulated cell adhesion. Vertebrate neural crest (NC) cells rapidly alter cadherin expression and localization at the cell surface during migration. Secreted Wnts induce some of these changes in NC adhesion and also promote specification of NC-derived pigment cells. Here, we show that the zebrafish transcription factor Ovo1 is a Wnt target gene that controls migration of pigment precursors by regulating the intracellular movements of N-cadherin (Ncad). more...

Organism:

Danio rerio

Type:

Expression profiling by array

Dataset:

GDS3719

Platform:

GPL1319

6 Samples

Download data: CEL

Analysis of wild-type embryos injected with Ovo1 morpholino antisense oligos. At 12 hpf, the Ovo1 morphants begin showing neural crest (NC) defects wherein a subset of NC cells aggregates in the dorsal midline above the neural tube. Results provide insight into the role of Ovo1 in NC migration.

Organism:

Danio rerio

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1319

Series:

GSE21539

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL18413 GPL24995

13 Samples

Download data

(Submitter supplied) We have performed single-cell RNA-seq of cranial NC cells in zebrafish over several stages during their migration

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18413

7 Samples

Download data: CSV

(Submitter supplied) The purpose of this study was to obtain an unbiased list of wnt-regulated genes in zebrafish neural crest.

Organism:

Danio rerio

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24995

6 Samples

Download data: TXT