Similar studies for GEO DataSets (Select 200020541) - GEO DataSets

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Items: 2

Select item 2000205411.

Livestock-associated MRSA lack accessory virulence determinants of human-associated MRSA

(Submitter supplied) Previous studies have documented the diversity of genetic background of methicillin-resistant S. aureus (MRSA) strains associated with healthcare (HA-MRSA), community (CA-MRSA) and livestock (LA-MRSA). The accessory and core-variable genome content of those strains remain largely unknown. To compare the composition of accessory and core-variable genome of Belgian MRSA strains according to host, population setting and genetic background, representative strains of HA- (n=21), CA- (n = 13) and ST398 LA-MRSA (n = 18) were characterized by a DNA-microarray (StaphVar Array) composed of oligonucleotide probes targeting ~400 resistance, adhesion and virulence associated genes.ST398 strains displayed very homogenous hybridization profiles (>94% gene content homology) irrespective of their host origin. more...

Organism:: Staphylococcus aureus

Type:: Genome variation profiling by array

Platform:: GPL7684
104 Samples

Download data: GPR

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Accession:: GSE20541

ID:: 200020541

Select item 2000137022.

StaphVar-DNA microarray analysis of accessory genome of community-acquired methicillin resistant Staphylococcus aureus

(Submitter supplied) Approximatively 75% of the genome of S. aureus (“core” genome) are highly conserved between strains, whereas the remaining 25% (“accessory” genome) are composed of variable regions that are mostly composed of mobile genetic elements (MGE), containing virulence and resistance genes. We have developed a composite DNA-microarray (StaphVar Array) which selectively targets 403 genes located on the accessory or core variable genome. more...