GEO DataSets

(Submitter supplied) [original title] Microarray analysis of DNA damage repair gene expression profiles in cervical cancer cells radioresistant to 252Cf neutron and X-rays. The aim of the study was to obtain stable radioresistant sub-lines from the human cervical cancer cell line HeLa by prolonged exposure to 252Cf neutron and X-rays. Radioresistance mechanisms were investigated in the resulting cells using SuperArray Oligo GEArray® Human DNA Damage Signaling Pathway Microarray.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL9811

3 Samples

Download data: TXT

(Submitter supplied) Background: In the event of an improvised nuclear device detonation, the prompt radiation exposure would consist of γ rays plus a neutron component that would contribute to the total dose. As neutrons cause more complex and difficult to repair damage to cells that would result in more severe health burden to affected individuals, it is paramount to be able to estimate the contribution of neutrons to an estimated dose, to provide information for those making treatment decisions. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10333

72 Samples

Download data: TXT

(Submitter supplied) Purpose: Single cell RNA-seq could observe heterogeneity of cell transcriptomes. The goals of this study are to compare the changes of ESCC cell line KYSE-180 RNA profiles in response to different doses of radiotherapy and to analyze the radio-resistance related genes.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16791

314 Samples

Download data: TXT

(Submitter supplied) Rationale: During excessive pressure or overload, cardiac cells are subjected to increased mechanical stress. We investigate how the stress response of cardiac cells to mechanical stress can be compared to genotoxic stresses induced by DNA damaging agents. Methods: Cultures enriched for cardiomyocytes and cultures of fibroblasts were derived from ventricles of neonatal rat hearts. In three independent experiments, both cell cultures were subjected to mechanical stress (cyclic stretch at 60 cycles/min), UV irradiation (10 J/m2), or X-rays (8.5 Gy). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

35 Samples

Download data: CEL, EXP

(Submitter supplied) Background: Radiotherapy plays an important role in the multimodal treatment of breast cancer. The response of a breast tumour to radiation depends not only on its innate radiosensitivity but also on tumour repopulation by cells that have developed radioresistance. Development of effective cancer treatments will require further molecular dissection of the processes that contribute to resistance. Methods: Radioresistant cell lines were established by exposing MDA-MB-231, MCF-7 and ZR-751 parental cells to increasing weekly doses of radiation. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21697

29 Samples

Download data: TXT

(Submitter supplied) The objective of this investigation was to characterize, at individual level, the transcriptional response and the onset of regenerative processes in mouse skin irradiated with different doses of fast neutrons. We performed a high-throughput gene expression analysis, by DNA oligonucleotide microarray on 24 three months old C57Bl/6 mice irradiated with 0, 0,2 and 1 Gy of mono-energetic 14 MeV neutron. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11211

8 Samples

Download data: GPR

(Submitter supplied) Prediction of response prior to radiotherapy is future direction of radiotherapy and identification of druggable targets in radiotherapy could overcome resistance. In order to identify a radiosensitive gene signature and elucidate relevant signaling pathways, microarrays using gastric cancer cells were analyzed before radiotherapy

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL15868

12 Samples

Download data: GPR

(Submitter supplied) Peripheral blood lymphocytes from a total of 15 healthy individuals without history of cancer (NoCa) were immortalized with Epstein-Barr virus. Cells were exposed to mock treatment (Mock), ultra-violet radiation (UV), or ionizing radiation (IR). For UV radiation treatment, cells were exposed to 10 J/m^2 and harvested for RNA 24 hours later. For IR treatment, cells were exposed to 5 Gy of IR and harvested for RNA 4 hours later. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS913

Platform:

GPL8300

45 Samples

Download data

Analysis of peripheral blood lymphocytes exposed to ultraviolet (10 J/m^2) or ionizing radiation (5 Gy). Lymphocytes obtained from 15 healthy individuals from ages 21 to 36 years and immortalized with Epstein-Barr virus. Results provide insight into transcriptional response to DNA damage.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 agent, 15 individual sets

Platform:

GPL8300

Series:

GSE1977

45 Samples

Download data

(Submitter supplied) One of the most important features of tumor microenvironment, imposing adverse effect on patient prognosis, is low oxygen tension. There are two types of hypoxia that may occur within tumor mass: chronic and cycling. Preliminary studies point at cycling hypoxia as being more relevant in induction of aggressive phenotype of tumor cells and radioresistance though little is known about the molecular mechanism of this phenomenon. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

27 Samples

Download data: CEL