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Links from GEO DataSets

Items: 7

1.

Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: MEF

(Submitter supplied) Telomerase, the essential enzyme that maintains telomere length, contains two core components, TERT and TR. While early studies in yeast and mouse both indicated that loss of telomerase leads to phenotypes that arise after an increased number of generations, due to telomere shortening, recent studies claim additional roles for telomerase components in transcription and the response to DNA damage. To test these telomere length maintenance-independent roles of telomerase components, we examined first generation mTR-/- and mTERT-/- mice with long telomeres. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE16430
ID:
200016430
2.

Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
24 Samples
Download data: CEL
Series
Accession:
GSE16731
ID:
200016731
3.

Comparing effects of mTR and mTERT deletion on gene expression and DNA damage response: liver

(Submitter supplied) Telomerase, the essential enzyme that maintains telomere length, contains two core components, TERT and TR. While early studies in yeast and mouse both indicated that loss of telomerase leads to phenotypes that arise after an increased number of generations, due to telomere shortening, recent studies claim additional roles for telomerase components in transcription and the response to DNA damage. To test these telomere length maintenance-independent roles of telomerase components, we examined first generation mTR-/- and mTERT-/- mice with long telomeres. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL
Series
Accession:
GSE16429
ID:
200016429
4.

mTert overexpression in MEFs

(Submitter supplied) Recent studies suggest that telomerase promotes cell growth by mechanisms that extend beyond the rescue of critically short telomeres. The in vitro model of mTert overexpressing MEFs recapitulates fundamental aspects of the growth-promoting effects of mTert in vivo. First, in Terc-proficient cells, mTert overexpression favors escape from replicative senescence and enhances anchorage-independent growth in response to oncogenic stress, which fits well with previous data showing that mTert overexpression promotes tumor formation. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Dataset:
GDS1211
Platform:
GPL339
4 Samples
Download data: CEL, CHP, EXP, RPT, TXT
Series
Accession:
GSE2684
ID:
200002684
5.
Full record GDS1211

mTert overexpression

Expression profiling of embryonic fibroblasts overexpressing mTert, the catalytic subunit of telomerase. Results identify potential downstream targets of telomerase.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent sets
Platform:
GPL339
Series:
GSE2684
4 Samples
Download data: CEL, CHP, EXP, RPT, TXT
DataSet
Accession:
GDS1211
ID:
1211
6.

Expression data from intestinal crypts and stroma of wild type and late generation (4th generation) telomerase-deficient mice

(Submitter supplied) Telomeres shorten with each round of cell division, and the expression of telomerase serves to lengthen telomeres. In the absence of telomerase, telomeres shorten to the point of uncapping and causes defects in tissues with high turnover, including the intestinal epithelium. In mice lacking telomerase (e.g. mTR-/-), telomeres critically shorten after several generations of telomerase deficiency, with pronounced defects in their intestine. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL6246
12 Samples
Download data: CEL, CHP
Series
Accession:
GSE90820
ID:
200090820
7.

mTert induction in p21-positive cells counteracts capillary rarefaction and pulmonary emphysema

(Submitter supplied) Lung diseases develop when telomeres are shortened beyond a critical point. We have constructed a mouse model in which the catalytic subunit of telomerase (mTert), or its catalytically inactive form (mTertCI), is expressed from the p21Cdkn1a promoter. We found that this particular expression of mTert reduces senescence of endothelial cells (EC) in lungs of aged mice, as well as emphysema and pulmonary perivascular fibrosis. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL24247
11 Samples
Download data: MTX, TSV
Series
Accession:
GSE165218
ID:
200165218
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