GEO DataSets

(Submitter supplied) Human cancers result from a complex series of genetic alterations resulting in heterogeneous disease states. Dissecting this heterogeneity is critical for understanding underlying mechanisms and providing opportunities for therapeutics matching the complexity. Mouse models of cancer have generally been employed to reduce this complexity and focus on the role of single genes. Nevertheless, our analysis of tumors arising in the MMTV-Myc model of mammary carcinogenesis reveals substantial heterogeneity, seen in both histological and expression phenotypes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

126 Samples

Download data: CEL, CHP

(Submitter supplied) Loss of E2F transcription factos alters metastatic capacity of MMTV-PyMT tumors. We used microarrays to futher characterize the effects of E2F loss on mammary tumorigenesis in MMTV-PyMT mice.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

80 Samples

Download data: CEL

(Submitter supplied) HER2 / Neu is amplified and overexpressed in a large proportion of human breast cancers, but the signaling pathways that contribute to tumor development and metastatic progression are not completely understood. Using gene expression data and pathway signatures we predicted a role for activator E2F transcription factors in Neu induced tumors. This was genetically tested by interbreeding Neu transgenics with knockouts of the three activator E2Fs. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

60 Samples

Download data: CEL

(Submitter supplied) We used microarrays to compare gene expression profiles between mouse mammary tumors initiated by Myc to those that have escaped Myc oncogene dependence.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

75 Samples

Download data: CEL

(Submitter supplied) Comparison the gene expression profiles of mouse mammary tumors derived from MMTV-PyMT transgenic in five different strains including FVB/NJ, I/LnJ F1, NZB/B1NJ F1, MOLF/Ei F1 and LP/J F1 and identification of signatures of tumor virulence. **NOTE: Migrated from caArray 1.x, identifier='gov.nih.nci.ncicb.caarray:Experiment:1015897560599049:1'

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

10 Samples

Download data: CEL, CHP

(Submitter supplied) We used microarrays to futher characterize the effects of T58A mutation in Myc on mammary tumorigenesis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

17 Samples

Download data: CEL

(Submitter supplied) The fibroblast growth factor pathway is known to cooperate with the highly oncogenic Wnt/beta-catenin pathway in mouse models of breast cancer. To investigate the mechanisms involved in this cooperativity, we utilized MMTV-driven transgenic mouse lines expressing a drug-inducible model for FGF Receptor signaling (iFGFR) crossed with the previously characterized MMTV-Wnt-1 mouse model. In these bigenic mice, both iFGFR1 and iFGFR2 activation resulted in a dramatic enhancement of mammary tumorigenesis. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL2881

18 Samples

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(Submitter supplied) Background. Oncogene overexpression in primary cells often triggers the induction of a cellular safeguard response promoting senescence or apoptosis. Secondary cooperating genetic events are generally required for oncogene induced tumorigenesis to overcome these biologic obstacles. We employed array CGH for 8 genetically-engineered mouse models of mammary cancer to identify loci that might harbor genes that enhance oncogene-induced tumorigenesis. more...

Organism:

Mus musculus

Type:

Genome variation profiling by array

Platform:

GPL11288

45 Samples

Download data: TXT

(Submitter supplied) We performed affymetrix gene expression profiling on mammary tumors from eight well-characterized genetically engineered Mouse (GEM) models of human breast cancer. The gene expression data will be combined with the miRNA gene expression data from the corresponding mammary tumors and tissues for integrated miRNA and mRNA gene expression analysis, which are useful in improving the identification of miRNA targets from potential targets identified in silico.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4077

Platform:

GPL8321

46 Samples

Download data: CEL

Analysis eight well-characterized genetically engineered mouse (GEM) models of human breast cancer , including MMTV-H-Ras, -Her2/neu, -c-Myc, -PymT, -Wnt1 and C3(1)/SV40 T/t-antigen transgenic mice, BRCA1(fl/fl);p53(+/-);MMTV-cre knock-out mice and the p53(fl/fl);MMTV-cre transplant model.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 9 genotype/variation, 3 strain, 2 tissue sets

Platform:

GPL8321

Series:

GSE23938

46 Samples

Download data: CEL

(Submitter supplied) A transgenic mouse model, MMTV-Wnt/ILK, with mammary specific expression of both Wnt-1 and ILK, was generated by crossing the two mouse lines MMTV-Wnt-1 and MMTV-ILK. Affymetrix Mouse Exon chips were hybridized with material from four independent mammary tumors from each MMTV-Wnt-1 and MMTV-Wnt/ILK transgenic model, in order to identify possible signaling differences involved during increased tumor incidence.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6096

8 Samples

Download data: CEL, CHP

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array; Genome variation profiling by array

Platforms:

GPL11383 GPL10481 GPL4092

71 Samples

Download data: TXT

(Submitter supplied) The histone deacetylase inhibitor Entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.

Organism:

Mus musculus

Type:

Genome variation profiling by array

Platform:

GPL4092

22 Samples

Download data: TXT

(Submitter supplied) The histone deacetylase inhibitor Entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10481

22 Samples

Download data: TXT

(Submitter supplied) The histone deacetylase inhibitor Entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL11383

27 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:

GPL21103 GPL17021 GPL4134

22 Samples

Download data: TXT

(Submitter supplied) validate and study CRISPR/Cas9 knock down line by RNA-seq

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

4 Samples

Download data: TXT

(Submitter supplied) Study gene expression in mouse mammary tumors single cell RNA-seq, study CRISPR/Cas9 knock down line by RNA-seq

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

8 Samples

Download data: TXT

(Submitter supplied) compare expression of two groups of tumors

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

10 Samples

Download data: TXT

(Submitter supplied) Mice have been used as models for human breast cancers for many years, however, it is still unclear which murine models faithfully represent human tumor phenotypes. To address this question, we used DNA microarrays to characterize 10 different murine mammary models and compared these data to the expression patterns from primary human breast tumors. Hierarchical clustering analysis of the murine samples showed that the WAP-Myc, MMTV-Neu, MMTV-PyMT, WAP-Int3, and C3(1)-Tag tumors were highly correlated within each model. more...

Organism:

Homo sapiens; Mus musculus

Type:

Expression profiling by array

4 related Platforms

354 Samples

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