Similar studies for GEO DataSets (Select 200015827) - GEO DataSets

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Items: 3

Select item 2000158271.

Gene expression analysis of 15-Lipoxygenase 2 (15-LOX2) transgenic mice

(Submitter supplied) 15-Lipoxygenase 2 (15-LOX2), a human-specific lipid-peroxidizing enzyme, is mainly expressed in luminal compartment of the normal prostate and often decreased or lost in prostate cancer (PCa). Previous studies from our lab implicate 15-LOX2 as a functional tumor suppressor. To better understand the biological role of 15-LOX2 in vivo, we established prostate-specific 15-LOX2 transgenic mice using the ARR2PB promoter. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL2872
6 Samples

Download data: TXT

Series

Accession:: GSE15827

ID:: 200015827

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001287242.

Gene expression profiling of Trop2+ and Trop2- luminal epithelial cells and stromal cells from young adult and old mouse prostates

(Submitter supplied) We set out to determine if distinct prostate luminal epithelial cell-types exhibited age-related differences in their gene expression profiles. We used fluorescence activated cell sorting to isolate Trop2+ and Trop2- luminal cells and EpCAM- CD49f- stromal cells from dissociated preparations of prostate tissue taken from young adult (3 months) and old (24 months of age) mice. RNA was extracted from sorted cells to evaluate differences in gene expression.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21493
14 Samples

Download data: TXT, XLSX

Series

Accession:: GSE128724

ID:: 200128724

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001223673.

Gene expression profiling of basal and luminal epithelial cells from young adult and old mouse prostates

(Submitter supplied) We set out to determine if prostate epithelial cell-types exhibited age-related differences in their gene expression profiles. We used fluorescence activated cell sorting to isolate basal and luminal cells from dissociated preparations of prostate tissue taken from young adult (3 months) and old (24 months of age) mice. RNA was extracted from sorted cells to evaluate differences in gene expression. We found significant enrichment for progenitor genes in old luminal cells including an immune/inflammatory profile that overlapped with a previously identified CD38-lo human prostate luminal progenitor signature. This study demonstrates a luminal progenitor signature in old mouse prostate.