GEO DataSets

(Submitter supplied) Serum-dependent transcriptional networks identify distinct functional roles for H-ras and N-ras during initial stages of the cell cycle Using oligonucleotide microarrays, we compared gene expression transcriptional profiles corresponding to the initial cell cycle stages of mouse fibroblasts lacking H-Ras and/or NRas with those of matching, WT controls. The similarity of transcription profiles among serum-starved fibroblasts of all different WT and ras knockout genotypes tested, indicated that H-Ras and N-Ras do not play significant roles in control of transcriptional responses to serum deprivation stress. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

39 Samples

Download data: CEL

(Submitter supplied) Analysis of the transcriptional profiles of mRNA and microRNA in Rasless fibroblasts. 4-Hydroxy-tamoxifen (4-OHT) treatment triggers removal of K-Ras expression in [H-Ras-/-;N-Ras-/-;K-Raslox/lox;RERTert/ert ] mouse fibroblasts (named K-Raslox) generating “Rasless” MEFs which are unable to proliferate, but recover proliferative ability after ectopic expression of constitutively active downstream kinases such as BRAF and MEK1. more...

Organism:

synthetic construct; Mus musculus

Type:

Expression profiling by array; Non-coding RNA profiling by array

Platforms:

GPL8786 GPL1261

51 Samples

Download data: CEL

(Submitter supplied) Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) is a conserved protein found in higher plants. In photosynthetic cells, the enzyme is involved in a shuttle transfer mechanism to export NADPH from the chloroplast to the cytosol. In this work, we demonstrate that GAPN gene express in leaves and roots at similar levels; showing the highest level of expression in flowers. To investigate the role of this enzyme in different plant tissues, we characterized a mutant from Arabidopsis thaliana having an insertion at the GAPN gene locus. more...

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL1941

3 Samples

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(Submitter supplied) Three major MAP kinase signaling cascades, ERK, p38 and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonal stimuli. In order to study the specific function of each MAP kinase branch in adult heart, we have generated three transgenic mouse models with cardiac specific and temporally regulated expression of activated mutants of Ras, MKK3 and MKK7, which are selective upstream activators for ERK, p38 and JNK, respectively. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1306

Platform:

GPL1261

36 Samples

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Analysis of adult hearts after induction of activated transgene mutants of Ras, MKK3, or MKK7, which are specific upstream activators of the MAP kinases ERK, p38, and JNK respectively. Hearts examined at various time points up to 4 weeks following each transgene induction using tamoxifen.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 gender, 4 genotype/variation, 3 time sets

Platform:

GPL1261

Series:

GSE3530

36 Samples

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