GEO DataSets

(Submitter supplied) Purpose: to evaluate changes in the transcriptome of hippocampal cells during the course of epileptogenesis, from the early events post status epilepticus (SE) to the onset of recurrent spontaneous seizures. Experimental Design: Gene expression profiling was analyzed in hippocampi of rats subjected to the pilocarpine model of epilepsy at different times during the course of epileptogenesis: 3 days post-SE (3D), 7 days post-SE (7D), and immediately (up to 12h) after the first spontaneous seizure (Chronic). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3827

Platform:

GPL2896

18 Samples

Download data: TXT

Analysis of hippocampal cells from Wistar adult males treated with pilocarpine during the course of epileptogenesis: 3 days post-status epilepticus (D3), D7, and immediately after the first spontaneous seizure (Chronic). Results provide insight into molecular mechanisms involved in epileptogenesis.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent, 3 time sets

Platform:

GPL2896

Series:

GSE14763

18 Samples

Download data: TXT

(Submitter supplied) experimental group and control group in rat post-status epilepticus model. Keywords: parallel sample

Organism:

Rattus norvegicus

Type:

Expression profiling by SAGE

Platform:

GPL23

2 Samples

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(Submitter supplied) The transcription factor SRF (serum response factor) mediates epilepsy mediated gene expression

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) Status epilepticus (SE) is a life-threatening condition that can give rise to a number of neurological disorders, including learning deficits, depression, and epilepsy. Many of the effects of SE appear to be mediated by alterations in gene expression. To gain deeper insight into how SE affects the transcriptome, we employed the pilocarpine SE model in mice and Illumina-based high-throughput sequencing to characterize alterations in gene expression from the induction of SE, to the development of spontaneous seizure activity. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL9250

8 Samples

Download data: XLS

(Submitter supplied) We mapped out temporal changes in mice hippocampus transcriptome as mRNA-seq and microRNA-seq after pilocarpine-induced SE to understand better molecular and cellular pathways that lead to neurodegenerative and neuroprotective processes after SE.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL17021 GPL24247

35 Samples

Download data: CSV

(Submitter supplied) Traumatic brain injury occasionally causes posttraumatic epilepsy. To elucidate the molecular events responsible for posttraumatic epilepsy, we established a rodent model that involved the injection of microliter quantities of FeCl3 solution into the amygdalar nuclear complex. We previously compared hippocampal gene expression profiles in the traumatic epilepsy model and normal rats at 5 days after brain injury (acute phase) and observed the role of inflammation. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL4135

16 Samples

Download data: TXT

(Submitter supplied) The present study was conducted to identify relevant genes that could be involved in the action of androgens in rat hippocampus. We compared hippocampal gene expression between controls and orchidectomized male rats.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14746

6 Samples

Download data: TXT