GEO DataSets

(Submitter supplied) Background :To evaluate the impact of the duration of chronic inflammation on gene expression in skeletal muscle biopsies (MBx) from untreated children with juvenile dermatomyositis (JDM) and identify genes and biological processes associated with the disease progression, expression profiling data from 16 girls with active symptoms of JDM greater or equal to 2 months were compared with 3 girls with active symptoms less than 2 months. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3417

Platform:

GPL96

23 Samples

Download data: CEL, CHP

Analysis of skeletal muscle biopsies from untreated girls with active symptoms of juvenile dermatomyositis (JDM) less than 2 months or greater than 2 months. Results provide insight into the impact of the duration of chronic inflammation on gene expression in muscle of untreated children with JDM.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 disease state sets

Platform:

GPL96

Series:

GSE11971

23 Samples

Download data: CEL, CHP

(Submitter supplied) Juvenile dermatomyositis (JDM), the most common pediatric inflammatory myopathy, is a systemic vasculopathy affecting young children. Epidemiology studies documenting an antecedent illness in the 3 mo before the first definite symptom (rash and/or weakness) of JDM are supported by immunologic data that suggest that the disease pathophysiology is Ag driven. The purpose of this study was to compare the gene expression profiles in muscle biopsies of four untreated DQA1*0501(+) JDM children with profiles from children with a known necrotizing myopathy (Duchenne muscular dystrophy), as well as an in vitro antiviral model (NF90), and healthy pediatric controls. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS215 GDS258

Platforms:

GPL246 GPL80

14 Samples

Download data: CEL

Examination of skeletal muscle from juvenile dermatomyositis (JDM) patients, a common pediatric inflammatory myopathy. Muscle biopsies processed singly or in mixed groups of two. Patients genotyped for TNFalpha which is associated with prolonged disease.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 8 specimen sets

Platform:

GPL80

Series:

GSE493

10 Samples

Download data: CEL

Examination of skeletal muscle from juvenile dermatomyositis (JDM) patients, a common pediatric inflammatory myopathy. Muscle biopsies processed singly or in mixed groups of two. Patients genotyped for TNFalpha which is associated with prolonged disease.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 specimen sets

Platform:

GPL246

Series:

GSE493

4 Samples

Download data: CEL

(Submitter supplied) The goals of this study are to identify differentially expressed microRNAs in muscle between JDM and normal healthy controls, and to better understand the pathophysiology of JDM.

Organism:

synthetic construct; Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL17382

24 Samples

Download data: TXT

(Submitter supplied) muscle biopsies of normal and dermatomyositis patients Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

23 Samples

Download data

(Submitter supplied) MHC-I overexpression in muscle biopsies is a hallmark of inflammatory myopathies.However the mechanisms of MHC-I overexpression in each disease is not well understood. Microarray analysis from MHC-I-microdissected myofibers showed a differential expression signature in each inflammatory myopathy. Innate immunity and IFN-I pathways are upregulated vs healthy controls, specifically in dermatomyositis (DM).

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4841

Platform:

GPL6244

19 Samples

Download data: CEL

Analysis of pathological skeletal muscle fibers from patients with dermatomyositis (DM), polymyositis (PM), or inclusion body myositis (IBM). Results provide insight into the molecular mechanisms underlying the pathogenesis of DM, PM, and IBM.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state sets

Platform:

GPL6244

Series:

GSE48280

19 Samples

Download data: CEL