Similar studies for GEO DataSets (Select 200010696) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Links from GEO DataSets

Items: 3

Select item 2000106961.

Expression analysis in A431_wt vs A431_GR cells

(Submitter supplied) A431 wild-type (wt) cancer cell line is sensitive to treatment with EGFR tyrosine kinase inhibitors (TKIs). By culturing it chronically under gefitinib, it eventually becomes resistant (A431_GR cell). We know of a few proteins involved in this mechanism of drug resistance, but a cDNA exprssion array would add information to other genes that might be involved in this resistance mechanism. We used microarrays to identify the differences in the global gene expression between A431_wt (wild-type) cells and A431_GR cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE10696

ID:: 200010696

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001573742.

Whole genome expression analysis of primary head and neck squamous cell carcinoma (HNSCC) cell lines and their isogenic gefitinib resistant cell lines

(Submitter supplied) Gene expression analysis of primary HNSCC cell lines and their corresponding gefitinib resistant cell lines

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
6 Samples

Download data: XLS

Series

Accession:: GSE157374

ID:: 200157374

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000289923.

Effect of a dual specificity PI3K/mTOR inhibitor, NVP-BEZ235, on human ovarian cancer cell lines grown in 3D culture

(Submitter supplied) Analysis of the effects of a dual specificity PI3K/mTOR inhibitor on two human ovarian cell lines, OV2008 and MCAS. Results provide insight into the adaptive response to PI3K/mTOR inhibition in matrix attached ovarian cancer cells. The PI3K/mTOR-pathway is the most commonly deregulated pathway in epithelial cancers and thus represents an important target for cancer therapeutics. Here we show that dual inhibition of PI3K/mTOR in ovarian cancer 3D-spheroids leads to death of the inner matrix-deprived cells, whereas matrix-attached cells are resistant. more...