GEO DataSets

(Submitter supplied) retinal ganglion cells die after optic nerve injury, either crush or transection. The molecular causesunderlying this degeneration are largely unkwon the purpose of this job is to find which (if any) gene regulation triggers RGC death with the final goal of design neuroprotective protocols Keywords: time course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3374

Platform:

GPL1355

35 Samples

Download data: CEL

Temporal analysis of retinas of animals following intraorbital optic nerve transection (IONT) or intraorbital nerve crush (IONC). Optic nerve injury, which is more severe with IONT than IONC, triggers retinal ganglion cell death. Results provide insight into the molecular basis of this degeneration.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 3 protocol, 7 time sets

Platform:

GPL1355

Series:

GSE9918

35 Samples

Download data: CEL

(Submitter supplied) To obtain and analyze early retinal changes at molecular level at 24h after ipsilateral intraorbital nerve radiation injury by gamma knife surgery

Organism:

Macaca mulatta

Type:

Expression profiling by array

Platform:

GPL3535

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

24 Samples

Download data: CEL

(Submitter supplied) Central nervous system (CNS) trauma and neurodegenerative disorders trigger a cascade of cellular and molecular events resulting in neuronal apoptosis and regenerative failure. The pathogenic mechanisms and gene expression changes associated with these detrimental events can be effectively studied using a rodent optic nerve crush (ONC) model. The purpose of this study was to use a mouse ONC model to: (a) evaluate changes in retina gene expression, (b) identify neurodegenerative pathogenic pathways and (c) discover potential new therapeutic targets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) Central nervous system (CNS) trauma and neurodegenerative disorders trigger a cascade of cellular and molecular events resulting in neuronal apoptosis and regenerative failure. The pathogenic mechanisms and gene expression changes associated with these detrimental events can be effectively studied using a rodent optic nerve crush (ONC) model. The purpose of this study was to use a mouse ONC model to: (a) evaluate changes in optic nerve (ON) gene expression, (b) identify neurodegenerative pathogenic pathways and (c) discover potential new therapeutic targets. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

12 Samples

Download data: CEL

(Submitter supplied) Retinal ganglion cell (RGC) death is the final consequence of many blinding diseases, where there is considerable variation in the time course and severity of RGC loss. Indeed, this process appears to be influenced by a wide variety of genetic and environmental factors. In this study we explored the genetic basis for differences in ganglion cell death in two inbred strains of mice. We found that RGCs are more susceptible to death following optic nerve crush in C57BL/6J mice (54% survival) than in DBA2/J mice (62% survival). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4234

18 Samples

Download data: TXT

(Submitter supplied) To gain a better understanding of the factors necessary for successful CNS regeneration, a temporal analysis of the changes in gene expression in the eye caused by optic nerve injury was conducted. Dual color oligonucleotide microarrays were used to compare total RNA harvested from the eyes of sham-operated and optic nerve-injured fish at 3, 24, and 168 hours following surgery. Optic nerve injured fish are compared to sham-operated fish in order to eliminate gene expression due to non-neuronal damage and inflammatory response. more...

Organism:

Danio rerio

Type:

Expression profiling by array

Platform:

GPL9117

4 Samples

Download data: TXT

(Submitter supplied) Purpose: The purpose of this study was　to use RNA-seq to investigate the molecular mechanisms of damage in the early stages of the response to axonal injury, before the onset of RGC death. Methods: 12-week-old wild-type (WT) mice were used in this study. The experiment group underwent an optic nerve crush (ONC) procedure to induce axonal injury in the right eye, and the control group underwent a sham procedure. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: CSV

(Submitter supplied) We performed RNA-seq analysis on the normal and 6-hour post-ONC retinas from the embryonic day (E) 20, postnatal day (P) 1 and P3 mice to determine the retinal transcriptome profiles. The identified differentially expressed genes (DEGs) could be associated with the degeneration of axonal growth capacity after birth, and axonal regeneration. Subsequent K‐means, GO, KEGG, PPI, and GSEA analysis revealed the biological processes and regulatory pathways involved in the DEGs.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

21 Samples

Download data: XLSX

(Submitter supplied) Aim: To identify the genes and non-coding RNAs (ncRNAs) involved in the neuroprotective actions of a dietary anti-oxidant (saffron) and of photobiomodulation. Methods: We used a previously published assay of photoreceptor damage, in which albino Sprague Dawley rats raised in dim cyclic illumination (12h 5 lux, 12h darkness) are challenged by 24h exposure to bright (1,000 lux) light. Experimental groups were protected against light damage by pretreatment with dietary saffron (1mg/kg/day for 21d) or photobiomodulation (10 J/cm2 at the eye, daily for 5d). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

18 Samples

Download data: CEL, CHP

(Submitter supplied) Reactive gliosis is a complex process that involves profound changes in gene expression. We used microarray to indentify differentially expressed genes and to investigate the molecular mechanisms of reactive gliosis in optic nerve head in response to optic nerve crush injury.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL8321

55 Samples

Download data: CEL

(Submitter supplied) Vasoregression is a hallmark of vascular eye diseases but the mechanisms involved are still largely unknown. We have recently characterized a rat ciliopathy model which develops primary photoreceptor degeneration and secondary vasoregression. To improve the understanding of secondary vasoregression in retinal neurodegeneration, we used microarray techniques to compare gene expression profiles in this new model before and after retinal vasoregression. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3846

Platform:

GPL1355

12 Samples

Download data: CEL

Analysis of retina from PKD-2-247 (TGR) males at 1 and 3 months of age (i.e., before and after retinal vasoregression). The TGR model develops primary photoreceptor degeneration and secondary vasoregression. Results provide insight into molecular mechanisms underlying development of vasoregression.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 age, 2 genotype/variation, 2 strain sets

Platform:

GPL1355

Series:

GSE20967

12 Samples

Download data: CEL