GEO DataSets

(Submitter supplied) Three groups of male +b and bb rats were obtained (ages between 6 and 14 months) and intestinal scrapes were taken. Tissues was combined from 3 rats per group and processed for gene chip analysis. Keywords: Belgrade, iron deficiency, intestine, microarray

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, CHP

(Submitter supplied) 12-week-old rats, iron-replete or iron-deficient. Three groups of each condition. 230A and 230B chips used with cRNA derived from jejunal scrapes. Keywords: ordered

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2073 GDS2074

Platforms:

GPL342 GPL341

12 Samples

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(Submitter supplied) The effect of iron-deficiency on duodenal gene expression was investigated in rats at different developmental stages. Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1054 GDS1055

Platforms:

GPL341 GPL342

60 Samples

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Analysis of jejunum from iron (Fe)-deprived 12-week-old Sprague Dawleys. Results provide insight into the genetic response to Fe deprivation in the jejunum versus the duodenum (characterized earlier) and the role of distal gut segments in increasing Fe absorption in conditions of Fe-deficiency.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 dose sets

Platform:

GPL342

Series:

GSE2269

6 Samples

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Analysis of jejunum from iron (Fe)-deprived 12-week-old Sprague Dawleys. Results provide insight into the genetic response to Fe deprivation in the jejunum versus the duodenum (characterized earlier) and the role of distal gut segments in increasing Fe absorption in conditions of Fe-deficiency.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 dose sets

Platform:

GPL341

Series:

GSE2269

6 Samples

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Analysis of effect of dietary iron deprivation on duodenum. Sprague Dawleys examined at various post-natal ages up to 36 weeks. Results identify iron-responsive genes, which include those involved in intestinal iron transport, during the course of post-natal development.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age, 2 dose sets

Platform:

GPL342

Series:

GSE1892

30 Samples

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Analysis of effect of dietary iron deprivation on duodenum. Sprague Dawleys examined at various post-natal ages up to 36 weeks. Results identify iron-responsive genes, which include those involved in intestinal iron transport, during the course of post-natal development.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age, 2 dose sets

Platform:

GPL341

Series:

GSE1892

30 Samples

Download data

(Submitter supplied) To identify a novel target for the treatment of heart failure, we examined gene expression in the failing heart. Among the genes analyzed, 12/15 lipoxygenase (12/15-LOX) was markedly up-regulated in heart failure. To determine whether increased expression of 12/15-LOX causes heart failure, we established transgenic mice that overexpressed 12/15-LOX in cardiomyocytes. Echocardiography showed that 12/15-LOX transgenic mice developed systolic dysfunction. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

2 Samples

Download data: CEL

(Submitter supplied) Hfe disruption in the mouse leads to experimental hemochromatosis by a mechanism which remains elusive. Evidence for at least five modifier genes has been obtained. These account for the higher iron load of Hfe-deficient D2 mice compared to B6 mice. Gene expression profling was used to clarify the mechanism of Hfe action and to identify potential modifier genes. Keywords: response to genetic modification

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

24 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) In the present study, we examined duodenal gene expression in rats subjected to immobilization, to elucidate the mechanism of the stress response in the duodenum. Keywords: stress response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

2 Samples

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(Submitter supplied) The goal of this study is to determine the role of the 12/15-lipoxygenase pathway in the development and maintenance of alveolar macrophages.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL24247

14 Samples

Download data: CSV, TXT

(Submitter supplied) The goal of this study is to determine the effect of the 12/15-lipoxygenase deficiency on transcriptomic profile of alveolar macrophages.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

8 Samples

Download data: TSV, TXT

(Submitter supplied) We aim to demonstrate a central role for omega-3 derived autacoids, termed specialized pro-resolving mediators (SPM), in the differentiation and maturation of Tregs.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

8 Samples

Download data: TXT

(Submitter supplied) Lipoxygenases (LOX) form a heterogeneous family of lipid peroxidizing enzymes capable of converting polyunsaturated fatty acids to their hydroperoxy derivatives. They have been implicated in basic cellular processes such as proliferation and differentiation but are also involved in the pathogenesis of various diseases such as inflammatory disorders and atherosclerosis. The catalytic activity of LOXs increases the intracellular peroxide tone, which is an important parameter for expression regulation of redox-sensitive genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

3 Samples

Download data: CHP, EXP

(Submitter supplied) Iron deficiency-induced anemia is generally a representative nutritional problem in most populations. We reported that the anemia due to dietary iron deficiency causes a variety of changes in nutrient metabolism, even leading to apoptosis as a result of associated endoplasmic reticulum (ER) stress in the rat liver. On the other hand, it appears that non-anemic iron-deficiency causes no serious problem because no appreciable down-regulation of hemoglobin synthesis occurs. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

10 Samples

Download data: CEL

(Submitter supplied) We established a mouse model, in which transcription factor Tcfap2c can be activated in an inducible and reversible manner in somatic tissues, taking advantage of the tetracycline-dependent regulatory system. Induction of the transgene led to robust expression in all tissues (except brain and testis) and lead to rapid mortality within 3-7 days. In the liver, accumulation of microvesicular lipid droplets and breakdown of major hepatic metabolism pathways resulted in steatosis.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

10 Samples

Download data: CEL, CHP

(Submitter supplied) In order to explore the functions of carbonic anhydrase VI (CAVI) more fully, we examined the transcriptomic responses to CAVI deficiency in the submandibular gland, stomach, and duodenum of Car6-/- mice by cDNA microarray. 94, 56, and 127 genes were up- or down-regulated in the above-mentioned tissues of Car6-/- mice, respectively. The functional clustering of differentially expressed genes revealed a number of altered biological processes. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

18 Samples

Download data: TXT