GEO DataSets

(Submitter supplied) The Lim1 gene has essential functions during several stages of kidney development. In particular, a tissue specific knockout in the early metanephric mesenchyme results in the formation of the earliest nephron precursor, the renal vesicle, but failure of this structure to progress to the next stage, the comma shaped body. To better understand the molecular nature of this developmental arrest we used a laser capture microdissection-microarray strategy to examine the perturbed gene expression pattern of the mutant renal vesicles. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2748

Platform:

GPL1261

9 Samples

Download data: CEL, CHP

Analysis of Lim1-null renal vesicles microdissected from embryonic day 12.5 kidneys. In Lim1 null embryos, the formation of comma shaped bodies from renal vesicles is interrupted. Results provide insight into the molecular basis of this developmental arrest.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE7257

9 Samples

Download data: CEL, CHP

(Submitter supplied) E11.5 metanephric mesenchyme and ureteric bud were dissected from the E11.5 kidney rudiment using fine manual microdissection (ureteric bud only) or both fine manual microdissection and laser capture microdissection (metanephric mesenchyme) to define the gene expression profiles of these structures. Additionally, HoxA11, HoxD11 compound null E11.5 metanephric mesenchyme was obtained through laser capture microdissection allowing analysis of possible Hox targets in kidney development. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2032

Platform:

GPL1261

16 Samples

Download data: CEL

(Submitter supplied) Complete (whole) embryonic kidneys were dissected from wild type and Hoxa11, Hoxd11 compound null embryons throughout development. Targets from two biological replicates of each were generated and the expression profiles were determined using Affymetrix MOE430A and MOE430B arrays. Comparisons between normal and mutant and comparisons of development samples identified global patterns of gene regulation in kidney development Keywords: embryonic metanephric kidney, kidney development, Hoxa11, Hoxd11, compound null targeted mice

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS2030 GDS2031

Platforms:

GPL339 GPL340

28 Samples

Download data: CEL, EXP

Analysis of metanephric mesenchyme (MM) dissected from the rudimentary kidney of embryonic day E11.5 Hoxa11 Hoxd11 null mutants and wild types. Gene expression in wild type ureteric bud (UB) examined. Hox11 genes are expressed in the early MM and are required for the induction of UB formation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:

GPL1261

Series:

GSE3822

16 Samples

Download data: CEL

Analysis of kidneys from Hoxa11/Hoxd11 double null mutants at various embryonic ages up to E16.5. Hox11 genes play critical roles in kidney development. Results provide insight into the molecular mechanisms of Hox11 function in kidney development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 age, 2 genotype/variation sets

Platform:

GPL340

Series:

GSE3808

14 Samples

Download data: CEL, EXP

Analysis of kidneys from Hoxa11/Hoxd11 double null mutants at various embryonic ages up to E16.5. Hox11 genes play critical roles in kidney development. Results provide insight into the molecular mechanisms of Hox11 function in kidney development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 age, 2 genotype/variation sets

Platform:

GPL339

Series:

GSE3808

14 Samples

Download data: CEL, EXP

(Submitter supplied) BACKGROUND: Lim1 is a homeobox gene that is essential for nephrogenesis. During metanephric kidney development, Lim1 is expressed in the nephric duct, ureteric buds, and the induced metanephric mesenchyme. Conditional ablation of Lim1 in the metanephric mesenchyme blocks the formation of nephrons at the nephric vesicle stage, leading to the production of small, non-functional kidneys that lack nephrons. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1748

Platform:

GPL1261

8 Samples

Download data: CEL

Analysis of embryonic day 14.5 and 18.5 kidneys from Lim1 conditional mutants. Lim1 is a homoebox gene that is essential for nephrogenesis. The mutant is ablated for Lim1 in the metanephric mesenchyme, resulting in nephron deficient kidneys. Results identify genes expressed in developing nephrons.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 development stage, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE4230

8 Samples

Download data: CEL

(Submitter supplied) We generated a murine genetic model of beta-catenin deficiency targeted to the ureteric bud cell lineage to study the role of beta-catenin mediated Wnt signaling during ureteric morphogenesis. Keywords: mutation

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3322

Platform:

GPL1261

6 Samples

Download data: CEL

Analysis of embryonic (E12.5) kidneys with beta-catenin deficiency targeted to the ureteric bud cell lineage. Inactivation of beta-catenin leads to abnormal ureteric branching and causes renal aplasia or dysplasia. Results provide insight into the role of beta-catenin during ureteric morphogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE9629

6 Samples

Download data: CEL

(Submitter supplied) Tumor tissue heterogeneity is a well known feature of several solid tumors. Neuroblastic Tumors (NTs) is a group of paediatric cancers with a great tissue heterogeneity. Most of NTs are composed of undifferentiated, poorly differentiated or differentiating neuroblastic (Nb) cells with very few or absent Schwannian stromal (SS) cells: these tumors are grouped as Neuroblastoma (Schwannian stroma-poor). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

28 Samples

Download data: CEL

(Submitter supplied) Using Affymetrix HG-U133-Plus 2.0 array and Laser Capture Microdissection techniques, we determined whether growth in different zones of the same tumor affected expression of genes by human pancreatic cancer cells. Human L3.6pl pancreatic cancer cells were implanted into the pancreas of nude mice. Gene expression patterns in tumor cells within the central and peripheral zones were compared and statistical differences were determined for 1222 genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

6 Samples

Download data: CEL, CHP

(Submitter supplied) A zebra mussel byssus cDNA microarray was used to identify the differentially expressed genes between attachment and detachment. Keywords: Gene differential expression

Organism:

Dreissena polymorpha

Type:

Expression profiling by array

Platform:

GPL6586

4 Samples

Download data: GPR

(Submitter supplied) 716 E.coli clones were selected from thirty-four 96-well plates and re-arranged into eight new 96-well plates. The overnight cultures from the eight 96-well plates were used to prepare the PCR templates. 10 μl of each bacterial culture was taken to mix with 90 μl sterile double distilled water. Then the mixture was incubated at 100 ℃ for 10 minutes followed by 15 minutes 1200g centrifuge. The supernatant was used as PCR templates. more...

Organism:

Dreissena polymorpha

3 Series

62 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

295 Samples

Download data: CEL, CSV

(Submitter supplied) We used microarrays to profile the expression levels of 285 ovarian samples in order to identify molecular subtypes of the tumour Keywords: disease state analysis

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

285 Samples

Download data: CEL, CSV

(Submitter supplied) We used microarrays to profile the expression levels of 5 tumour samples Keywords: expression difference of cell types in tumour samples

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

10 Samples

Download data: CEL, CSV

(Submitter supplied) This report is based on an ongoing study to examine gene expression differences in monkey lateral geniculate nucleus (LGN). For this study, samples from an Old World species, vervet monkey (Cercopithecus aethiops), were cross-hybridized to the Rhesus Macaque Genome Array (Affymetrix). Microarray analysis was performed using laser capture microdissected populations of individual neuronal cell bodies isolated from the LGN compared to heterogeneous samples from whole lamina. more...

Organism:

Macaca mulatta; Homo sapiens; Chlorocebus aethiops vervet

Type:

Expression profiling by array

Platforms:

GPL3535 GPL570

14 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) The ventrolateral hypothalamic parvafox (formerly called PV1-Foxb1) nucleus is an anatomical entity of recent discovery and unknown function. With a view to gaining an insight into its putative functional role(s), we conducted a gene-microarray analysis. The parvafox nucleus was specifically sampled by laser-capture microdissection and the transcriptome was subjected to a microarray analysis on Affymetrix chips. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL16570

6 Samples

Download data: CEL