GEO DataSets

(Submitter supplied) Study on selective vulnerability of certain brain regions to oxidative stress. Here we selected 4 brain regions (hippocampal CA1 and CA3, cerebral cortex, and cerebellar granular layer) to study this phenomenon. Keywords: Comparative analysis of different regions of the brain.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3726

Platform:

GPL341

12 Samples

Download data: CEL

Analysis of neurons from 4 brain regions: hippocampal CA1 and CA3, cerebellar CbG, and cerebral cortex. CA1 and CbG neurons are vulnerable to oxidative stress (OS), CA3 and cerebral cortex neurons resistant. Results provide insight into the molecular basis for selective neuronal vulnerability to OS.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 tissue sets

Platform:

GPL341

Series:

GSE7139

12 Samples

Download data: CEL

(Submitter supplied) Mechanistic study on the differential responses of the two hippocampal adjoining regions, i.e., CA1 and CA3, to elevated oxidative stress. Keywords: Time course stress response study

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3130

Platform:

GPL341

16 Samples

Download data: CEL

Anlaysis of CA1 and CA3 hippocampal slice cultures for up to 12 hours following treatment with duroquinone to induce oxidative stress (OS). Neurons in the CA1 region are sensitive to OS, while those in CA3 are resistant. Results provide insight into the molecular basis of this difference.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 4 time, 2 tissue sets

Platform:

GPL341

Series:

GSE6693

16 Samples

Download data: CEL

(Submitter supplied) The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-regulated early in the mouse brain in response to the ROS generator paraquat (PQ). However, the processes triggered by this up-regulation have not been explored.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3913

Platform:

GPL8321

18 Samples

Download data: CEL

Analysis of cerebellum from Apolipoprotein D loss-of-function (ApoD-KO) or gain-of-function (hApoD-Tg) mutants treated with reactive oxidative stress (ROS) generator paraquat. ApoD protects the nervous system against OS. Results provide insight into ApoD-mediated response to OS.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 3 genotype/variation sets

Platform:

GPL8321

Series:

GSE28643

18 Samples

Download data: CEL

(Submitter supplied) Multiple cell types and complex connection networks are an intrinsic feature of brain tissue. In this study we used expression profiling of homogeneous cell populations from specific microscopic regions of heterogeneous tissue sections isolated by laser capture microdissection (LCM) to determine insights into the molecular basis of brain pathology in prion disease. Temporal profiles in two mouse models of prion disease, bovine spongiform encephalopathy (BSE) and a mouse-adapted strain of scrapie (RML) were performed in microdissected regions of the CA1 and cerebellar granular that are enriched in neuronal cell bodies. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL4134

76 Samples

Download data: TXT

(Submitter supplied) Neuronal cultures were treated with candesartan at neuroprotective concentrations followed by excitotoxic glutamate amounts. Candesartan significantly reduced glutamate-induced inflammation. To provide mechanistic insight into the potential targets and pathways that may underlie these benefits, we performed genome wide expression profile analysis and evaluated the data by Ingenuity Pathway Analysis (IPA) and Gene Set Enrichment Analysis (GSEA). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL17117

16 Samples

Download data: CEL, CHP

(Submitter supplied) In this study we sought to examine gene expression in the cerebral cortex during development in the context of adaptive plasticity. In order to do this we introduced an approach designed to discriminate genes with variable as opposed to uniform patterns of gene expression and found that greater inter-individual variance is observed among children than among adults.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6947

37 Samples

Download data: TXT