GEO DataSets

(Submitter supplied) Extracts from the rhizome of Cimicifuga racemosa (black cohosh) are increasingly popular as herbal alternative to hormone replacement therapy (HRT) for the alleviation of postmenopausal disorders. However, the molecular mode of action and the active principles are presently not clear. Previously published data have been largely contradictory. We, therefore, investigated the effects of a lipophilic Cimicifuga rhizome extract on the ER+ breast cancer MCF-7 cells at transcriptional level in comparision to 17beta-estradiol and the ER antagonist tamoxifen. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3105

Platform:

GPL570

8 Samples

Download data: CEL

Analysis of MCF-7 breast cancer cells treated with a Cimicifuga racemosa extract. Extracts from the C. racemosa rhizome are used as an herbal alternative to hormone replacement therapy for alleviation of postmenopausal disorders. Results provide insight into the extract's molecular mode of action.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 agent sets

Platform:

GPL570

Series:

GSE6800

8 Samples

Download data: CEL

(Submitter supplied) Products derived from roots of Leuzea carthamoides DC. (maral root) are being promoted as anti-aging and adaptogenic. The phytoecdysteroids are considered as active principles with numerous beneficial effects, but little is known about the pharmacological properties of Leuzea extracts. We, therefore, investigated the effects of a lipophilic Leuzea root extract on ER+ breast cancer MCF-7 cells at transcriptional level in comparison to 17beta-estradiol and the ER antagonist tamoxifen. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

8 Samples

Download data: CEL

(Submitter supplied) Previous studies indicate that the triterpene glycoside actein from the herb black cohosh inhibits growth of human breast cancer cells. This study seeks to identify genes altered in human breast cancer cells by treatment with actein, using gene expression analysis. We treated MDA-MB-453 human breast cancer cells with actein at 2 doses, 20 or 40 μg/mL, for 6 or 24 h. We identified 5 genes that were activated after each of the treatments that are known to play a role in cellular responses to diverse stresses, including the DNA damage and unfolded protein responses. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS3638

Platform:

GPL571

16 Samples

Download data: CEL

Analysis of MDB-MB-453 breast cancer cells treated with 20 or 40 ug/ml actein for 6 or 24 hours. Actein is a triterpene glycoside from the herb black cohosh and inhibits the growth of cancer cells in vitro. Results provide insight into the molecular basis of this inhibitory effect.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent, 3 dose, 2 time sets

Platform:

GPL571

Series:

GSE7848

16 Samples

Download data: CEL

(Submitter supplied) Microarray analysis was performed to evaluate the global gene expression profiles of MCF-7 breast cancer cells treated with tomato leaves extract (TLE) in 1 hr and 48 hrs of treatment. Several of genes with p < 0.05 and fold-change cut-off <2.00 from human genome had significantly changed after the treatments. Its showed the greatest roles in cancer cells growth and were found either to be down-regulated or up-regulated in cells after the treatment.TLE gave significant expression effects towards several genes such as CRYAB, PIM1, BTG1, CYR61, HIF1A, CEBP-beta, TXNIP, THBS1, HMG1L1 and HIST2H3D genes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

9 Samples

Download data: CEL, CHP