GEO DataSets

(Submitter supplied) Activation of the pregnane X receptor (NR1I2) by drugs and other xenobiotics stimulates (or suppresses) expression of numerous genes involved in the metabolic elimination of foreign compounds and some toxic endogenous substrates. We used microarray analysis to identify genes whose expression in rat liver was significantly altered by pregnenolone 16alpha-carbonitrile (PCN) treatment. Keywords: a single ip injection of PCN (100 mg/kg), 8 h treatment

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS2093 GDS2094

Platforms:

GPL341 GPL342

19 Samples

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Analysis of livers of animals treated with pregnenolone 16alpha-carbonitrile (PCN), a pregnane X receptor (NR1I2) agonist. NR1I2 is a member of the nuclear receptor family of ligand-activated transcription factors, and regulates the transcription of genes encoding xenobiotic metabolizing enzymes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL342

Series:

GSE4959

9 Samples

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Analysis of livers of animals treated with pregnenolone 16alpha-carbonitrile (PCN), a pregnane X receptor (NR1I2) agonist. NR1I2 is a member of the nuclear receptor family of ligand-activated transcription factors, and regulates the transcription of genes encoding xenobiotic metabolizing enzymes.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL341

Series:

GSE4959

10 Samples

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(Submitter supplied) This study aimed to quantify and compare the mRNA abundance of major xenobiotic processing genes in liver following activation of PXR and CAR using RNA-Seq

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

9 Samples

Download data: ZIP

(Submitter supplied) Fipronil (CAS #: 120068-37-3), a widely used insecticide, has been described as a thyroid disruptor in rat inducing a marked increase in thyroxine (T4) clearance resulting in a decrease in T4 plasma concentration. These effects seem to require the bioactivation of fipronil via its biotransformation into fipronil sulfone by cytochromes P450 (CYP). Here, we hypothesized that fipronil-induced thyroid disruption may, at least in part, result from the induction of hepatic enzymes involved in the metabolism of thyroid hormones. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL7294

15 Samples

Download data: TXT

(Submitter supplied) RCCHanTM:WIST male rats were administered for 7 days by oral gavage with vehicle (corn oil) or 100 mg/kg/day of pregnenolone-16α-carbonitrile(PCN). We used microarrays to evaluate gene expression profiling in rat liver at the early phase of treatment with PCN.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL14797

6 Samples

Download data: TXT

(Submitter supplied) The effect of prototypical pregnane receptor X (PXR) agonist (pregnenolone 16α-carbonitrile) PCN on hepatic gene expression was studied in mice primary hepatocytes.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL9746

2 Samples

Download data: CEL

(Submitter supplied) The mice were treated i.p. with pregnenolone-16-α-carbonitrile (PCN, 50mg/kg dissolved in DMSO-corn oil 1:3) or vehicle (DMSO-corn oil 1:3) once daily for four days. The mice were fasted for four hours and then administered glucose (2g/kg) by oral gavage or further kept on fasting. The mice were sacrificed 1 hour after glucose administration.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL21278

12 Samples

Download data: TXT

(Submitter supplied) The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was conducted on liver and testis from Wistar Han IGS rats fed myclobutanil (M: 500, 2000 ppm), propiconazole (P: 500, 2500 ppm), or triadimefon (T: 500, 1800 ppm) from gestation day six to postnatal day 92. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

34 Samples

Download data: CEL

(Submitter supplied) The modes of triazole reproductive toxicity have been characterized by an observed increased in serum testosterone and reduced insemination and fertility indices. The key events involved in the disruption in testosterone homeostasis and reduced fertility remain unclear. Gene expression analysis was conducted on liver and testis from Wistar Han IGS rats fed myclobutanil (M: 500, 2000 ppm), propiconazole (P: 500, 2500 ppm), or triadimefon (T: 500, 1800 ppm) from gestation day six to postnatal day 92. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

35 Samples

Download data: CEL

(Submitter supplied) A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology. We have used a supervised classification approach to systematically mine a large microarray database derived from livers of compound-treated rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL5425 GPL5426 GPL5424

5312 Samples

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