GEO DataSets

(Submitter supplied) In the present study, we examined duodenal gene expression in rats subjected to immobilization, to elucidate the mechanism of the stress response in the duodenum. Keywords: stress response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

2 Samples

Download data

(Submitter supplied) d-serine is naturally present throughout the human body. It is also used as add-on therapy for treatment-refractory schizophrenia. d-Serine interacts with the strychnine-insensitive glycine binding site of NMDA receptor, and this interaction could lead to potentially toxic activity (i.e., excitotoxicity) in brain tissue. The transcriptomic changes that occur in the brain after d-serine exposure have not been fully explored. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3643

Platform:

GPL1355

24 Samples

Download data: CEL

Analysis of forebrains of animals treated with up to 500 mg/kg D-serine for 96 hours. D-serine is involved in many physiological processes through its interaction with the glycine binding site of the NMDA receptor. Results provide insight into the impact of D-serine exposure on neuronal functions.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 agent, 6 dose sets

Platform:

GPL1355

Series:

GSE10748

24 Samples

Download data: CEL

(Submitter supplied) Social stress is well known to be involved in the occurrence and exacerbation of mental illness, and also various life-style related diseases such as hyperinsulinemia, hyperglycemia, cardiovascular diseases and cancer. However, there is little information on tissue-specific gene expression in response to social stress, which reflects our daily life. Liver is one of the most important organs, owing to its biological functions such as energy metabolic homeostasis, metabolization and detoxification of endo- and exogenous substances. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

6 Samples

Download data: CEL, CHP

(Submitter supplied) The effect of iron-deficiency on duodenal gene expression was investigated in rats at different developmental stages. Keywords: time-course

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Datasets:

GDS1054 GDS1055

Platforms:

GPL341 GPL342

60 Samples

Download data

Analysis of effect of dietary iron deprivation on duodenum. Sprague Dawleys examined at various post-natal ages up to 36 weeks. Results identify iron-responsive genes, which include those involved in intestinal iron transport, during the course of post-natal development.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age, 2 dose sets

Platform:

GPL342

Series:

GSE1892

30 Samples

Download data

Analysis of effect of dietary iron deprivation on duodenum. Sprague Dawleys examined at various post-natal ages up to 36 weeks. Results identify iron-responsive genes, which include those involved in intestinal iron transport, during the course of post-natal development.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 5 age, 2 dose sets

Platform:

GPL341

Series:

GSE1892

30 Samples

Download data

(Submitter supplied) Aging of skeletal muscle tissue is characterized by loss of metabolic and contractile competence. It is thought that this phenomenon is driven via extrinsic and intrinsic factors. In order to identify age-dependent changes intrinsic to the muscle cell, microarray transcriptional profiles and measurements of glucose metabolism were performed in primary cultured human myotubes at different time points over seven weeks. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS647

Platform:

GPL8300

7 Samples

Download data

Examination of aging myotubes from a muscle biopsy incubated in glucose. Myotubes in 25 mM glucose at 2, 3, 4, 5, and 7 weeks, and in 10 mM glucose at 4 weeks examined in reference to 0 mM glucose control at 1 week.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 growth protocol, 6 time sets

Platform:

GPL8300

Series:

GSE1144

7 Samples

Download data

(Submitter supplied) Analysis of gene expression changes in the LV of a rodent heart that occur with uncontrolled diabetes We used microarrays to detail the global changes that occur in gene expression in the LV of the heart as a result of STZ-induced diabetes. Keywords: single time point, comparison control animal v. diabetic animal

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

14 Samples

Download data: CEL

(Submitter supplied) The alkylating agent N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) induces cellular DNA damages and other comprehensive alterations that lead to chromosomal aberrations, mutations, tumor initiations, and cell death. However, the molecular mechanism of MNNG-induced cellular stress remains unclear.We have genome-wide analyzed early transcriptional responses of human FL amnion epithelial cells after exposure to three relatively low doses of MNNG (0.2, 1.0, and 10.0µM),and differential gene expression profiles were obtained 4 h after exposure using oligonucleotide microarrays followed by validation with quantitative real-time RT-PCR. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL96 GPL97

16 Samples

Download data: CEL, EXP

(Submitter supplied) Background: Pseudomonas aeruginosa, a pathogen infecting those with cystic fibrosis, encounters toxicity from phagocyte-derived reactive oxidants including hydrogen peroxide during active infection. P. aeruginosa responds with adaptive and protective strategies against these toxic species to effectively infect humans. Despite advances in our understanding of the responses to oxidative stress in many specific cases, the connectivity between targeted protective genes and the rest of cell metabolism remains obscure. more...

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array

Dataset:

GDS1469

Platform:

GPL84

9 Samples

Download data

Expression profiling of strain PA01 exposed to hydrogen peroxide, a reactive oxygen species, at a sublethal concentration of 1 mM. Results identify upregulation of pyocin (bacteriocin) genes as a potentially novel defensive scheme in response to oxidative attack by infected host cells.

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL84

Series:

GSE3090

9 Samples

Download data

(Submitter supplied) It generally believes that moderate stress could have protective and adaptive effects, but less is known about the moderate or experimental stress on CNS in stimulated animals. This study aims to investigate the potential gene expression in nociception-related central regions induced by moderate experimental stress in rats. Rats were given moderate restrain for 50 min and using cDNA microarrays to compare different gene expression in central regions. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL3498

30 Samples

Download data: TXT

(Submitter supplied) Reference pool RNA versus RNA from dexamethasone treated gut cells. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1465

4 Samples

Download data

(Submitter supplied) Idiosyncratic drug reactions (IDRs) cause significant morbidity and mortality. In an animal model of IDRs, 50-80% of Brown Norway rats exposed to D-penicillamine develop an autoimmune syndrome after several weeks of treatment. The symptoms of the IDR are similar to that observed in humans who take D-penicillamine. The mechanism of this reaction is unknown, and no effective biomarkers have been identified to predict susceptibility. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1394

Platform:

GPL341

12 Samples

Download data: CEL, DAT, EXP

Analysis of Brown Norway males 6 hours after treatment with 150 mg/kg of D-penicillamine. Some rheumatoid arthritis patients treated with D-penicillamine develop idiosyncratic drug reactions (IDR). Results provide insight into mechanisms underlying IDR.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL341

Series:

GSE2825

12 Samples

Download data: CEL, DAT, EXP

(Submitter supplied) Three groups of male +b and bb rats were obtained (ages between 6 and 14 months) and intestinal scrapes were taken. Tissues was combined from 3 rats per group and processed for gene chip analysis. Keywords: Belgrade, iron deficiency, intestine, microarray

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

12 Samples

Download data: CEL, CHP

(Submitter supplied) Comparison of gene expression of heart (left vent) and diaphragm of normal Sprague Dawley rats, young adult Keywords: Cell type comparison

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3224

Platform:

GPL341

12 Samples

Download data: CEL

Analysis of normal heart left ventricle and diaphragm of young-adult Sprague Dawley males. Concurrent rhythmic contractions of the diaphragm and heart are needed to sustain life. Results provide insight into transcriptional strategies for ensuring long-term energy supplies in these two muscles.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 tissue sets

Platform:

GPL341

Series:

GSE6943

12 Samples

Download data: CEL