GEO DataSets

(Submitter supplied) Rats underwent surgery for LAD ligation for 30 min followed by reperfusion. Heart ventricles were collected 2d or 7d after reperfusion. Keywords: rat heart ventricles, LAD - left anterior descending coronary artery, IR - ischemia-reperfusion

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1959

Platform:

GPL341

12 Samples

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Analysis of ischemic heart ventricles 2 or 7 days after reperfusion. Ischemia induced by occlusion of the left anterior descending coronary artery. Results provide insight into the molecular mechanisms involved in the early and late inflammatory phases of acute myocardial infarction.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol, 2 time sets

Platform:

GPL341

Series:

GSE4105

12 Samples

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(Submitter supplied) heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL154 GPL153

12 Samples

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(Submitter supplied) hearts from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords = rat Keywords = heart Keywords = cytokine Keywords = inflammation Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL153

6 Samples

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(Submitter supplied) heart from rats exposed to cardiopulmonary bypass (CPB) vs sham-operated controls Keywords = rat Keywords = cardiac Keywords = cytokine Keywords = inflammation Keywords: repeat sample

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL154

6 Samples

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(Submitter supplied) Pulmonary vascular occlusions due to thromboemboli can result in pulmonary hypertension and right heart damage. Treatments to clear the vascular obstructions such as i.v. heparain or thrombolytics can resolve the hypertension but right ventricular damage often occurs first. Methods of protecting the right ventricle from hypertensive damage during the course of acute treatment to clear the thromboemboli are needed. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

20 Samples

Download data: CEL, CHP

(Submitter supplied) Cardiac hypertrophy was induced by treadmill running. Sedentary animals served as controls. Gene expression was determined by Affymetrix RGU34A GeneChip's to identify genes with differential expression in an adaptive model of cardiac hypertrophy. Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS654

Platform:

GPL85

12 Samples

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Analysis of heart left ventricles from animals subjected to 7 weeks treadmill exercise compared with sedentary controls. Provides insight into molecular mechanisms of left ventricular hypertrophy.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL85

Series:

GSE739

12 Samples

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(Submitter supplied) We have studied the genes activated in human liver transplantation to identify potential target genes for the prevention or treatment of related injuries. In a first protocol, in order to evaluate the effect of Ischemia-Reperfusion Injury (IRI) on gene expression profile, we compared gene expression levels in transplanted-reperfused livers versus basal values in donor livers, identifying 795 genes significantly modified in human liver after transplantation. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

15 Samples

Download data: CEL

(Submitter supplied) Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by using local adenovirus-mediated gene transfer of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38α in rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2487

Platform:

GPL1355

10 Samples

Download data: CEL, EXP

Analysis of left heart ventricles of transgenics overexpressing the mitogen-activated protein kinase (MAPK) p38 in their hearts. p38 is involved in the pathophysiology of inflammatory diseases. Results provide insight into the role of p38 in the heart.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1355

Series:

GSE3866

10 Samples

Download data: CEL, EXP

(Submitter supplied) Vitamin A is the only known compound that produces spontaneous fractures in rats. In an effort to resolve the molecular mechanism behind this effect, we fed young rats high doses of vitamin A and performed a global transcriptional analysis of diaphyseal bone after one week, i.e. just before the first fractures appeared. Microarray gene expression analysis revealed that 68 transcripts were differentially expressed in hypervitaminotic cortical bone and 118 transcripts were found when the bone marrow was also included. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

16 Samples

Download data: CEL

(Submitter supplied) We have developed an endovascular micro-endomyocardial biopsy device (Micro-EMB) with an outer diameter of 0.4 mm in order to minimize procedural risk, sampling trauma, and increase sampling specificity compared to conventional EMB. Here, we have taken micro-EMB samples from swine myocardium before, during and after myocardial infarction to detect potential gene expression responses.

Organism:

Sus scrofa

Type:

Expression profiling by high throughput sequencing

Platform:

GPL26351

85 Samples

Download data: TXT

(Submitter supplied) Purpose: In the current study, we used RNA-Seq to determine the transcriptional changes and understand the genetic reprogramming of the diaphragm in the chronic phase post-myocardial infarction. Methods: Rat diaphragm mRNA profiles 16 weeks post Sham and Myocardial infarction (MI) surgeries were generated by deep sequencing using llumina NextSeq 500. The sequence reads that passed quality filters were analyzed at the transcript level with TopHat followed by Cufflinks. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20084

8 Samples

Download data: CSV