GEO DataSets

(Submitter supplied) Background: Pseudomonas aeruginosa, a pathogen infecting those with cystic fibrosis, encounters toxicity from phagocyte-derived reactive oxidants including hydrogen peroxide during active infection. P. aeruginosa responds with adaptive and protective strategies against these toxic species to effectively infect humans. Despite advances in our understanding of the responses to oxidative stress in many specific cases, the connectivity between targeted protective genes and the rest of cell metabolism remains obscure. more...

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array

Dataset:

GDS1469

Platform:

GPL84

9 Samples

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Expression profiling of strain PA01 exposed to hydrogen peroxide, a reactive oxygen species, at a sublethal concentration of 1 mM. Results identify upregulation of pyocin (bacteriocin) genes as a potentially novel defensive scheme in response to oxidative attack by infected host cells.

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL84

Series:

GSE3090

9 Samples

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(Submitter supplied) In the present study, we employed Affymetrix Pseudomonas aeruginosa GeneChip arrays to investigate global gene expression profiles during the cellular response of Pseudomonas aeruginosa to sodium hypochlorite Keywords: Antimicrobial response

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array

Platform:

GPL84

9 Samples

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(Submitter supplied) In the present study, we employed Affymetrix Pseudomonas aeruginosa GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Pseudomonas aeruginosa to Chlorhexidine diacetate, which involved initial growth inhibition and metabolism. Keywords: Transcriptome study

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array

Platform:

GPL84

9 Samples

Download data: CEL

(Submitter supplied) Response to Oxidative Stress via administration of Allylamine Keywords: dose response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS463

Platform:

GPL85

3 Samples

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Analysis of Sprague Dawley thoracic aorta response to repreated oxidative stress induced via administration of 35 or 70 mg/kg allylamine for 20 days.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 dose sets

Platform:

GPL85

Series:

GSE610

3 Samples

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(Submitter supplied) Global expression profiling of airway epithelial cells infected with Pseudomonas aeruginosa and the rsmA mutant. Recent work in our laboratory investigated the impact of RsmA on a number of airway epithelial cell phenotypes including actin depolymerization, cytotoxicity and invasion. These cellular phenotypes were influenced by the positive effect of RsmA on the expression of the TTSS in P. aeruginosa (Mulcahy et al. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2287

Platform:

GPL96

6 Samples

Download data: CEL, EXP

Analysis of airway epithelial cells infected with Pseudomonas aeruginosa PAO1 or the rsmA mutant. RsmA is a small RNA-binding protein that plays a role in the regulation of virulence-related genes in P. aeruginosa. Results provide insight into the influence of RsmA-regulated functions on the host.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 genotype/variation, 2 infection sets

Platform:

GPL96

Series:

GSE4485

6 Samples

Download data: CEL, EXP

(Submitter supplied) Virulence factor production and the development of biofilms in Pseudomonas aeruginosa have been shown to be regulated by two hierarchically organised quorum sensing (QS) systems via small acyl-homoserine lactone (AHL) signal molecules. Recently, a third bacterial signal molecule, the Pseudomonas quinolone signal (PQS), has been identified, which positively regulates a subset of genes dependent on the QS systems. more...

Organism:

Pseudomonas aeruginosa PAO1; Pseudomonas aeruginosa

Type:

Expression profiling by array

Dataset:

GDS2764

Platform:

GPL84

12 Samples

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Analysis of Pseudomonas aeruginosa cells treated for up to 20 hours with 3,4-(di)hydroxy-heptyl-quinoline (PQS), a bacterial intercellular signaling molecule. Results provide insight into the role of PQS in the bacterial communication system termed quorum sensing.

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL84

Series:

GSE3836

12 Samples

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(Submitter supplied) Gene expression in response to changes in sulfur supply was studied in P. aeruginosa E601, a cystic fibrosis isolate that displays mucin sulfatase activity, and in P. aeruginosa PAO1. A large family of genes was found to be upregulated by sulfate limitation in both isolates, encoding sulfatases and sulfonatases, transport systems, oxidative stress proteins, and a sulfate-regulated TonB/ExbBD complex. more...

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array

Dataset:

GDS2870

Platform:

GPL84

20 Samples

Download data: CEL

Analysis of Pseudomonas aeruginosa E601 grown in media containing various sources of sulfur. P. aeruginosa E601 is a cystic fibrosis isolate that exhibits mucin sulfatase activity. Results provide insight into the pathways that respond to the nature of the supply of sulfur.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 5 growth protocol, 2 strain sets

Platform:

GPL84

Series:

GSE8408

20 Samples

Download data: CEL

(Submitter supplied) In the present study, we examined duodenal gene expression in rats subjected to immobilization, to elucidate the mechanism of the stress response in the duodenum. Keywords: stress response

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL85

2 Samples

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(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to hydrogen peroxide-induced oxidative stress, which involved initial growth inhibition and subsequent recovery. Keywords: Time course

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Dataset:

GDS1666

Platform:

GPL1339

12 Samples

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Analysis of Staphylococcus aureus cells exposed for 10 or 20 minutes to hydrogen peroxide to induce oxidative stress. Macrophages and other lymphocytes use reactive oxygen species such as H2O2 to destroy the bacteria. Results provide insight into mechanisms involved in S. aureus-host interactions.

Organism:

Staphylococcus aureus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL1339

Series:

GSE3415

12 Samples

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(Submitter supplied) Purpose: The aim of this study was to determine the transcriptional response of P. aeruginosa PA14 to HOCl and HOSCN stress, and determine genes dependent on RclR (PA14_07340) regulation. Methods: PA14 WT and ∆rclR exponential phase cultures were exposed to sub-lethal amounts of HOCl or HOSCN (2.2 or 0.8 mM, respectively), or untreated, and after 20 minutes of exposure, RNA was extracted and gene expression analysed by RNA-seq. more...

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21297

12 Samples

Download data: XLSX

(Submitter supplied) In the present study, we employed Affymetrix Pseudomonas aeruginosa GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Pseudomonas aeruginosa to ortho-phenylphenol, which involved initial growth inhibition and metabolism. Keywords: Time course

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array

Platform:

GPL84

12 Samples

Download data: CEL

(Submitter supplied) Through chemical contamination of natural environments, microbial communities are exposed to many different types of chemical stressors; however, research on whole genome responses to this contaminant stress is limited. This study examined the transcriptome response of a common soil bacterium, Pseudomonas aeruginosa, to the common environmental contaminant pentachlorophenol (PCP). Cells were grown in chemostats at a low growth rate to obtain substrate-limited, steady-state, balanced-growth conditions. more...

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array

Platform:

GPL84

12 Samples

Download data

(Submitter supplied) In the present study, we employed Affymetrix Staphylococcus aureus GeneChip arrays to investigate the dynamics of global gene expression profiles during the cellular response of Staphylococcus aureus to peracetic acid, which involved initial growth inhibition and subsequent partial recovery. Keywords: Time course

Organism:

Staphylococcus aureus

Type:

Expression profiling by array

Dataset:

GDS2105

Platform:

GPL1339

12 Samples

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Analysis of Staphylococcus aureus cultures at 10 and at 20 minutes following treatment with 1 mM peracetic acid, an antimicrobial disinfectant. Results provide insight into the toxicogenomic response of S. aureus to a sublethal concentration of peracetic acid during the two growth states.

Organism:

Staphylococcus aureus

Type:

Expression profiling by array, count, 2 agent, 2 time sets

Platform:

GPL1339

Series:

GSE4184

12 Samples

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