GEO DataSets

(Submitter supplied) Isolated perfused rat hearts exposed to isoflurane or ischemic preconditioning, a subgroup followed by 40 minutes of ischemia and 3 hours of reperfusion. Exact protocol available from the authors. Keywords = preconditioning Keywords = anesthetics Keywords = ischemia/reperfusion Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS808

Platform:

GPL85

30 Samples

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Comparison of Wistar heart left ventricles preconditioned against ischemia by pharmacologic treatment with isoflurane to those preconditioned by exposure to sublethal ischemia. Expression profiles examined in preconditioned hearts either perfused alone or subjected to ischemia and then reperfused.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 3 agent, 2 protocol sets

Platform:

GPL85

Series:

GSE1616

30 Samples

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(Submitter supplied) Ischemia/reperfusion injuries is a known complication to hepatic surgery. Ischemic pre- (IPC) and postconditioning (IPO) protects the liver against ischemia/reperfusion-injuries. Expression profiling were performed on liver biopsies seeking to identify molecular mediators of the protective properties.

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL6247

48 Samples

Download data: CEL

(Submitter supplied) Analysis of left venticular myocardium following morphine-induced sustained ligand activated preconditioning (SLP). Results provide insight into the molecular pathways affected by morphine-induced SLP in the pre- and post-ischemic heart.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

24 Samples

Download data: TXT

(Submitter supplied) Ischemic preconditioning represents the most powerful mechanism of cardioprotection. The mechanisms mediating the second window of preconditioning (SWOP) differ from those mediating first window preconditioning. We hypothesized that chronic ischemia induced by repetitive ischemic stimuli would be mediated by yet different molecular mechanisms. Accordingly, conscious, chronically instrumented pigs (n=5/group) were submitted to a protocol of classical SWOP (two 10-min episodes of coronary artery occlusion followed by 24 hr reperfusion) and compared to pigs submitted to repetitive occlusion/reperfusion (RCO) by repeating 6 episodes of SWOP 12 hrs apart, and to a model of repetitive coronary stenosis (RCS), in which 6 episodes of 90 min coronary stenosis were performed 12 hrs apart. more...

Organism:

Sus scrofa

Type:

Expression profiling by array

Platform:

GPL3533

20 Samples

Download data: CEL

(Submitter supplied) Objectives: While cardiac scar tissue is damaged irreversibly, hibernating myocardium is characterized by reversible contractile dysfunction. Limited data are available in humans regarding the molecular biology of hibernating myocardium. The aim of this study was to identify new molecular mechanisms distinctive for human hibernating myocardium by gene expression analysis. Results: Of 4,171 transcripts examined, we identified 86 to be differentially expressed. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

4 related Platforms

44 Samples

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(Submitter supplied) Neuroprotective therapies for retinal degeneration may be used to rescue retinal cells and preserve vision. Hypoxic preconditioning stabilizes the transcription factor HIF-1α in the retina and strongly protects photoreceptors in an animal model of light-induced retinal degeneration. Our data suggest that neuroprotection after hypoxic preconditioning of the retina is the result of the differential expression of a multitude of genes which may act in concert to protect visual cells against a toxic insult. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS3521

Platform:

GPL1261

24 Samples

Download data: CEL

Analysis of retinas subjected to hypoxia for 6 hours and subsequent reoxygenation for up to 16 hours. Hypoxic preconditioning protects photoreceptors from light damage in animal model. Results provide insight into the molecular basis of this protective effect.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol, 4 time sets

Platform:

GPL1261

Series:

GSE14366

24 Samples

Download data: CEL

(Submitter supplied) Specific gene changes after exposure to the heart toxin, bis(2-chloroethoxy)methane, were analyzed to elucidate critical pathways associated with recovery from heart toxicity. Bis(2-chloroethoxy)methane was administered to male F344/N rats at 0, 200, 400, or 600 mg/kg by dermal exposure for up to 16 days. Heart toxicity occurred at day 2 of exposure in all three regions of the heart (atrium, ventricle, interventricular septum) and was characterized by myofiber vacuolation, necrosis, mononuclear-cell infiltration, and atrial thrombosis. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2566

Platform:

GPL890

12 Samples

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Analysis of hearts exposed to the heart toxin bis(2-chloroethoxy)methane (CEM) for 2 or 5 days. Toxicity occurs at day 2 of CEM dosing, and recovery at day 5 despite continued dosing. Results provide insight into the molecular basis of heart toxicity and recovery during the exposure to CEM.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, log2 ratio, 2 time sets

Platform:

GPL890

Series:

GSE4254

12 Samples

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(Submitter supplied) The mechanisms through which cardioplegia affords cardioprotection is complex and can not be investigated as a single entity but rather must be investigated as a system. In order to improve understanding of the molecular processes modulating the effects of global ischemia and the cardioprotection afforded by cardioplegia we have constructed rabbit heart cDNA libraries and have isolated, sequenced and identified a compendium of non-redundant cDNAs for use in microarray analysis. more...

Organism:

Oryctolagus cuniculus

Type:

Expression profiling by array

Platform:

GPL8111

3 Samples

Download data: TXT, XLS

(Submitter supplied) Time series of eleven breast cancer samples subjected to different cold ischemic stress of up to 3 hr post tumor excision. A different 2x2 factorial within this study evaluated the effect of stabilization method (RNAlater vs snap freezing) and stablization delay (0 and 40 min) at room temperature.

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4088

Platform:

GPL96

86 Samples

Download data: CEL

Analysis of breast tumor samples preserved using 2 different RNA stabilization methods (RNAlater or snap freezing) up to 3 hours post tumor excision. Results provide insight into the effects of tissue handling on RNA integrity and microarray measurements from resected breast cancers.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 11 individual, 35 other, 2 protocol, 6 time sets

Platform:

GPL96

Series:

GSE25011

86 Samples

Download data: CEL

(Submitter supplied) Purpose: Develop an analytical pipeline for dynamic RNA-seq experiments and highlight the importance of considering surgery effect in MI-induced models Methods: Mice have undergone surgery, hearts were harvested and RNA was extracted, sequenced and analyzed by DESeq2 R package. Differentially expressed transcripts were clustered by WGCNA and then analyzed to identify enriched biological processes and transcription factors. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

24 Samples

Download data: TXT