GEO DataSets

Analysis of livers from complement-deficient C3 knockout mutants injected with a first generation LacZ adenovirus (Ad) vector. Ad vectors are used in gene delivery. Results provide insight into the role of the complement system in elaborating multiple Ad-associated acute inflammatory responses.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 2 genotype/variation, 2 infection sets

Platform:

GPL3222

Series:

GSE4128

29 Samples

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(Submitter supplied) Replication-deficient adenovirus (Ad) type 5 capsids induce potent host innate immune responses. One system pivotal in host innate immune defense is the complement system. Intriguingly, excessive or inappropriate complement activation can result in extreme tissue damage and systemic inflammatory responses similar to those noted immediately after high dose systemic Ad vector injections. To determine if the complement system has a significant role in intensifying Ad-associated acute toxicities, we compared complement deficient (C3-knockout (KO)) mice responses to those of wild type (WT) mice following systemic challenge with Ad vectors. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1826

Platform:

GPL3222

29 Samples

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(Submitter supplied) The innate immune response to 1st generation adenoviral vectors was ascertained through high level infection of primary cells from a inbred mouse strain, replete with an intact and functioning TLR system. Keywords: Immune Response

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS1528 GDS1529

Platforms:

GPL75 GPL76

24 Samples

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Analysis of primary C57BL/6 embryonic fibroblasts infected with a 1st generation adenoviral (Ad) vector. Ad vectors are known to induce certain genes and impact innate response networks. Results provide insight into the innate immune response of cells to Ad transduction.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 infection sets

Platform:

GPL76

Series:

GSE3172

12 Samples

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Analysis of primary C57BL/6 embryonic fibroblasts infected with a 1st generation adenoviral (Ad) vector. Ad vectors are known to induce certain genes and impact innate response networks. Results provide insight into the innate immune response of cells to Ad transduction.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 infection sets

Platform:

GPL75

Series:

GSE3172

12 Samples

Download data