GEO DataSets

Analysis of multipotent neural progenitor cells (NPCs) propagated by growth on media containing cystatin C and fibroblast growth factor-2. NPCs isolated from hippocampus neural stem cells. Results provide insight into the frequency of L1 element retrotransposition events in multipotent NPCs.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 cell type sets

Platform:

GPL85

Series:

GSE2499

20 Samples

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(Submitter supplied) Experiment comparing Low-density, CCg derived, progenitors (LDP) with high-density progenitors (HDP), and neurons (LDN) and astrocytes (LDA) derived from the LDP condition Keywords: other

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS1396

Platform:

GPL85

20 Samples

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(Submitter supplied) The orphan nuclear receptor Nurr1 has been shown to be critical for the development of ventral midbrain dopaminergic neurons. Consequently, the development of ES cells overexpressing Nurr1 has raised hope for the development of cell replacement therapies for Parkinson's Disease to replace degenerated dopaminergic neurons. However, the molecular consequences of Nurr1 on gene expression in these cells remain unknown. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS2027

Platform:

GPL81

4 Samples

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Expression profiling of neural stem cell lines overexpressing the orphan nuclear receptor Nurr1. Nurr1 is critical for the development of the ventral midbrain dopaminergic neurons, the cells primarily lost in Parkinson's disease.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 2 other sets

Platform:

GPL81

Series:

GSE3571

4 Samples

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(Submitter supplied) This SuperSeries is composed of the SubSeries listed below. Publication: D Janecki, R Sen, N Szóstak, A Kajdasz, M Kordys, K Plawgo, D Pandakov, A Philips, Z Warkocki (2024): LINE-1 mRNA 3’ end dynamics shape its biology and retrotransposition potential. Nucleic Acids Research. https://doi.org/10.1093/nar/gkad1251

Organism:

Homo sapiens; synthetic construct

Type:

Other

Platforms:

GPL24676 GPL26526

52 Samples

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(Submitter supplied) Human LINE-1 retrotransposons can mobilize in the human genome by a copy-and-paste machanism involving RNA intermediates. LINE-1 mRNA 3' ends play a major role in initiation of reverse transcription (a step retrotransposition). To assess the impact of RNA 3’ end dynamics of LINE-1 mRNA on its retrotransposition potential in human cells we analyzed 3' non-templated ends on LINE-1 mRNA by 3' RACE-seq. more...

Organism:

Homo sapiens

Type:

Other

Platform:

GPL24676

30 Samples

Download data: TXT

(Submitter supplied) Human LINE-1 retrotransposons can mobilize in the human genome by a copy-and-paste machanism involving RNA intermediates. LINE-1 mRNA 3' ends play a major role in initiation of reverse transcription (a step retrotransposition). To assess the impact of RNA 3’ end dynamics of LINE-1 mRNA on its retrotransposition potential in human cells we analyzed 3' non-templated ends on LINE-1, and control GAPDH and PABPC4 mRNAs by 3' RACE-seq. more...

Organism:

synthetic construct; Homo sapiens

Type:

Other

Platforms:

GPL24676 GPL26526

22 Samples

Download data: TXT

(Submitter supplied) Background: Besides the consequences of retrotransposition, long interspersed element 1 (L1) retrotransposons can affect the host genome though their antisense promoter. In addition to the sense promoter, the evolutionarily recent L1 retrotransposons, which are present in several thousand copies, also possess an anti-sense promoter that can produce L1 chimeric transcripts (LCT) composed of the L1 5’ UTR followed by the adjacent genomic sequence. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL20301

1 Sample

Download data: TXT

(Submitter supplied) Somatic L1 retrotransposition events have been shown to occur in epithelial cancers1-8. Here, we attempted to determine how early somatic L1 insertions occurred during the development of gastrointestinal (GI) cancers. Using L1-targeted resequencing (L1-seq), we studied different stages of four colorectal cancers arising from colonic polyps, seven pancreatic carcinomas, as well as seven gastric cancers. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array

Platform:

GPL6801

12 Samples

Download data: CEL, TXT