GEO DataSets

Analysis of adult hearts after induction of activated transgene mutants of Ras, MKK3, or MKK7, which are specific upstream activators of the MAP kinases ERK, p38, and JNK respectively. Hearts examined at various time points up to 4 weeks following each transgene induction using tamoxifen.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 gender, 4 genotype/variation, 3 time sets

Platform:

GPL1261

Series:

GSE3530

36 Samples

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(Submitter supplied) Non-phosphorylating glyceraldehyde-3-phosphate dehydrogenase (GAPN) is a conserved protein found in higher plants. In photosynthetic cells, the enzyme is involved in a shuttle transfer mechanism to export NADPH from the chloroplast to the cytosol. In this work, we demonstrate that GAPN gene express in leaves and roots at similar levels; showing the highest level of expression in flowers. To investigate the role of this enzyme in different plant tissues, we characterized a mutant from Arabidopsis thaliana having an insertion at the GAPN gene locus. more...

Organism:

Arabidopsis thaliana

Type:

Expression profiling by array

Platform:

GPL1941

3 Samples

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(Submitter supplied) Three major MAP kinase signaling cascades, ERK, p38 and JNK, play significant roles in the development of cardiac hypertrophy and heart failure in response to external stress and neural/hormonal stimuli. In order to study the specific function of each MAP kinase branch in adult heart, we have generated three transgenic mouse models with cardiac specific and temporally regulated expression of activated mutants of Ras, MKK3 and MKK7, which are selective upstream activators for ERK, p38 and JNK, respectively. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1306

Platform:

GPL1261

36 Samples

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(Submitter supplied) Mitogen-activated protein kinases (MAPKs) regulate cardiomyocyte growth and apoptosis in response to extracellular stimulation, but the downstream effectors that mediate their pathophysiological effects remain poorly understood. We determined the targets and role of p38 MAPK in the heart in vivo by using local adenovirus-mediated gene transfer of constitutively active upstream kinase mitogen-activated protein kinase kinase 3b (MKK3bE) and wild-type p38α in rats. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS2487

Platform:

GPL1355

10 Samples

Download data: CEL, EXP

Analysis of left heart ventricles of transgenics overexpressing the mitogen-activated protein kinase (MAPK) p38 in their hearts. p38 is involved in the pathophysiology of inflammatory diseases. Results provide insight into the role of p38 in the heart.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL1355

Series:

GSE3866

10 Samples

Download data: CEL, EXP

(Submitter supplied) RNA from testis from 4 mus musculus species was hybridized on affymetrix gene chip U74Av2. Subspecies-specific differences in expression level were then extracted by conditioning on outcomes to cases where the expression in one subspecies differed significantly from all others but these did not differ significantly among each other. Keywords: other

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1884

Platform:

GPL81

8 Samples

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Expression profiling of testes from subspecies castaneus, domesticus, musculus, and a strain from Iran (BID).

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 strain sets

Platform:

GPL81

Series:

GSE2471

8 Samples

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(Submitter supplied) Background: Cardiac kinases play a critical role in the development of heart failure, and represent potential tractable therapeutic targets. However, only a very small fraction of the cardiac kinome has been investigated. To identify novel cardiac kinases involved in heart failure, we employed an integrated transcriptomics and bioinformatics analysis and identified Homeodomain-Interacting Protein Kinase 2 (HIPK2) as a novel candidate kinase. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

9 Samples

Download data: CEL

(Submitter supplied) Serum-dependent transcriptional networks identify distinct functional roles for H-ras and N-ras during initial stages of the cell cycle Using oligonucleotide microarrays, we compared gene expression transcriptional profiles corresponding to the initial cell cycle stages of mouse fibroblasts lacking H-Ras and/or NRas with those of matching, WT controls. The similarity of transcription profiles among serum-starved fibroblasts of all different WT and ras knockout genotypes tested, indicated that H-Ras and N-Ras do not play significant roles in control of transcriptional responses to serum deprivation stress. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

39 Samples

Download data: CEL

(Submitter supplied) Aldosterone is known to have a number of direct adverse effects on the heart, including fibrosis and myocardial inflammation. However, genetic mechanisms of aldosterone action on the heart remain unclear. This experiment investigated of temporal changes in gene expression profile of the whole heart induced by acute administration of a physiologic dose of aldosterone in the mouse. mRNA levels of 34,000 known mouse genes were measured at eight time points after aldosterone administration using oligonucleotide microarrays and compared to those of the control animals who underwent a sham injection. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS1303

Platform:

GPL1261

15 Samples

Download data: CEL, EXP

Analysis of heart from C57BL/6 males injected with 10 ug/kg aldosterone. Hearts examined at various time points up to 12 hours after injection. Results provide insight into the molecular mechanisms underlying the adverse effects of aldosterone on the heart.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 8 time sets

Platform:

GPL1261

Series:

GSE3440

15 Samples

Download data: CEL, EXP

(Submitter supplied) Comparative analysis of mouse cardiac left ventricle gene expression: voluntary wheel exercise and pregnancy-induced cardiac hypertrophy

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

18 Samples

Download data: CEL