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Links from GEO DataSets

Items: 1 to 20 of 142

1.
Full record GDS4545

Cardiac right ventricle hypertrophy model

Analysis of right ventricle (RV) from C57BL/6 males subjected to hemoclip installation around the pulmonary artery (PA) for up to 6 weeks. PA clipping induces RV hypertrophy (RVH) while avoiding detrimental RV pressure overload. Results provide insight into the molecular basis of RV remodeling.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 protocol, 3 time, 2 tissue sets
Platform:
GPL6246
Series:
GSE30428
12 Samples
Download data: CEL
DataSet
Accession:
GDS4545
ID:
4545
2.
Full record GDS6064

Arthritic tarsal joints induced by collagen: time course

Analysis of tarsal joints for up to 4 weeks following treatment with collagen to induce arthritis. Collagen induced arthritis is a model for rheumatoid arthritis. Results provide insight into the molecular events underlying the inflammation and bone remodeling that occurs in inflammatory arthritis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 5 time sets
Platform:
GPL6246
Series:
GSE61140
15 Samples
Download data: CEL
3.
Full record GDS5881

Nebulin deficiency effect on the soleus

Analysis of soleus muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
4.
Full record GDS5880

Nebulin deficiency effect on the quadriceps

Analysis of quadriceps muscles from 6 week old males with a conditional knockout of nebulin in their striated muscles. Nebulin is a giant filamentous protein that is coextensive with actin filaments of the skeletal muscle sarcomere. Results provide insight into the role of nebulin in adult muscles.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE70213
12 Samples
Download data: CEL
5.
Full record GDS5825

Interleukin-1α deficiency effect on injured spinal cord

Analysis of spinal cord segment from interleukin (IL)-1α -/- and IL-1β -/- C57BL/6 adults 24 hrs after spinal cord injury (SCI). IL-1α and IL-1β belong to a family of cytokines playing a key role in neurodegeneration. Results provide insight into the role of IL-1α in the neuropathology of SCI.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL6246
Series:
GSE70302
12 Samples
Download data: CEL
6.
Full record GDS5824

Short-term high fat diet effect on epididymal adipose fractions: time course

Analysis of primary adipocytes from epididymis of C57BL/6J males fed a 60% high fat diet (HFD) for up to 7 days to induce obesity. Results provide insight into the molecular mechanisms underlying insulin resistance in adipose tissues during early obesity.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol, 3 time, 2 tissue sets
Platform:
GPL6246
Series:
GSE65557
18 Samples
Download data: CEL
7.
Full record GDS5673

Glucagon effect on hepatocytes deficient in lysine acetyltransferase 2B or WD repeat-containing protein 5

Analysis of C57BL6/J primary hepatocytes depleted of either lysine acetyltransferase 2B (KAT2B) or WD repeat-containing protein 5 (WDR5) via shRNA knockdown, then stimulated with glucagon for 90 minutes. Results provide insight into the roles of KAT2B and WDR5 in hepatic gluconeogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 agent, 3 genotype/variation sets
Platform:
GPL6246
Series:
GSE47179
10 Samples
Download data: CEL, CHP
8.
Full record GDS5668

Macrophage-restricted interleukin-10 receptor deficiency effect on colonic resident macrophages

Analysis of FACS-sorted, interleukin-10 receptor (IL-10R)-deficient intestinal macrophages from 6-week-old C57BL/6 animals. IL-10 is a pleiotropic anti-inflammatory cytokine. Results provide insight into the role of IL-10 sensing by intestinal macrophages in gut homeostasis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE56444
5 Samples
Download data: CEL
DataSet
Accession:
GDS5668
ID:
5668
9.
Full record GDS5665

Pathogen-associated molecular-pattern curdlan effect on interleukin-2 deficient GM-CSF myeloid dendritic cells

Analysis of GM-CSF myeloid dendritic cells (GM-DCs) isolated from interleukin-2 (IL-2) knockouts and activated with curdlan, a pathogen-associated molecular pattern (PAMP). GM-DCs secrete cytokines such as IL-2, upon PAMP activation. Results provide insight into role of IL-2 signaling in DCs.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE58120
12 Samples
Download data: CEL
DataSet
Accession:
GDS5665
ID:
5665
10.
Full record GDS5645

v-raf murine sarcoma viral oncogene homolog B-mutant thyroid carcinoma tumors

Analysis of papillary thyroid carcinoma (TPOCreER; BrafV600E) and anaplastic thyroid carcinoma (TPOCreER; BrafV600E; p53 -/-) tumors. BRAF and TP53 mutations co-occur often in ATCs, especially those with a precursor PTC. Results provide insight into the molecular basis of PTC to ATC progression.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 2 tissue sets
Platform:
GPL6246
Series:
GSE55933
10 Samples
Download data: CEL
11.
Full record GDS5641

Retinoblastoma ∆G/∆G mutant allele effect on quiescent embryonic fibroblasts

Analysis of retinoblastoma (RB) ∆G/∆G mutant MEFs deprived of serum to induce quiescence. The mutant allele disrupts RB protein (pRB) interactions with the transactivation domain of E2F transcription factors. Results provide insight into pRB functions in cell cycle control independent of E2F.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 3 genotype/variation sets
Platform:
GPL6246
Series:
GSE54924
9 Samples
Download data: CEL
12.
Full record GDS5636

Basic helix-loop-helix transcription factor Bhlhe40-deficient differentiated T helper cell subsets in vitro

Analysis of naive CD4+ T cells purified from the spleen of bHLH transcription factor Bhlhe40 knockouts, cultured in TH1, TH2 or TH17 conditions for 4 days, and stimulated with PMA and ionomycin for 4 hrs. Results provide insight into the role of Bhlhe40 in the polarized TH cell lineages.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation, 3 growth protocol sets
Platform:
GPL6246
Series:
GSE49166
6 Samples
Download data: CEL
13.
Full record GDS5628

Circadian nuclear receptor REV-ERBα deficiency effect on ventral midbrain

Analysis of ventral midbrain (VMB) from Rev-erbα knock-outs that were entrained under a 12hr light-dark photoperiod for >10 days, kept in darkness for 2 days, and sacrificed on the third day. REV-ERBα is associated with bipolar disorder. Results provide insight into the role of REV-ERBα in VMB.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE55119
4 Samples
Download data: CEL
DataSet
Accession:
GDS5628
ID:
5628
14.
Full record GDS5618

Pregnancy effect on transplanted male pancreatic islets

Analysis of male donor islets transplanted into streptozotocin-induced diabetic females then removed at pregnancy day 12.5. During pregnancy, the mother’s insulin demand increases to sustain fetal growth. Results provide insight into the molecular response of male beta cells during pregnancy.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 gender, 4 protocol, 2 tissue sets
Platform:
GPL6246
Series:
GSE59143
20 Samples
Download data: CEL
15.
Full record GDS5456

TGIF1-transduced MLL-AF9-transformed leukemic cells

Analysis of mixed lineage leukemia (MLL)-AF9 transformed cells (MAF9) transduced with TGF-β induced factor 1 (TGIF1). TGIF1 is a member of the TALE (three-amino-acid loop extension) family of homeodomain-containing transcription factors. Results provide insight into the role of TGIF1 in MAF9 cells.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 2 protocol sets
Platform:
GPL6246
Series:
GSE55713
6 Samples
Download data: CEL
DataSet
Accession:
GDS5456
ID:
5456
16.
Full record GDS5449

Mek1 Mek2 double mutation effect on the embryonic brain dorsal cortex

Analysis of brain dorsal cortices of E18.5 embryos deleted for Mek1 and Mek2, dual specificity kinases. Mek1 and Mek2 are components of the RAF/MEK/ERK singaling pathway. Results provide insight into the role of Mek1 and Mek2 in gliogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE40675
4 Samples
Download data: CEL, CHP
17.
Full record GDS5421

Transcription factor E2-2 haplodeficiency effect on systemic lupus erythematosus model: splenocytes

Analysis of splenocytes from WT, B6.Sle1.Sle3 (lupus mice) and B6.Sle1.Sle3 Tcf4+/− (Sle/het) mice haplodeficient for the transcription factor E2-2 (Tcf4). E2-2 is a specific regulator of plasmacytoid dendritic cell (pDC) development. Results provide insight into role of pDC in SLE pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, count, 3 genotype/variation sets
Platform:
GPL6246
Series:
GSE57324
8 Samples
Download data: CEL
18.
Full record GDS5419

MEK inhibitor PD-0325901 and rapamycin combined treatment effect on malignant peripheral nerve sheath tumor model

Analysis of malignant peripheral nerve sheath tumors (MPNST) from NPcis animals (carrying Nf1 and p53 mutations) treated with rapamycin, MEK inhibitor PD-0325901, or the combination of rapamycin and PD-0325901. Results provide insight into the molecular mechanisms underlying MPNST pathogenesis.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 4 protocol sets
Platform:
GPL6246
Series:
GSE57141
8 Samples
Download data: CEL
19.
Full record GDS5414

Core binding factor β deficiency effect on bone marrow derived-granulocyte macrophage progenitor cells

Analysis of purified Lin-c-kit+Sca1-CD16/32+ GMP cells from Cbfβ-conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE55227
4 Samples
Download data: CEL
20.
Full record GDS5413

Core binding factor β deficiency effect on bone marrow derived-LSK hematopoietic stem cells

Analysis of purified Lin-c-kit+Sca1+ LSK cells from Cbfβ- conditional knockout mice. Runx/Cbfb heterodimers play important roles in hematopoietic cell development. Results provide insight into molecular mechanisms by which Cbfβ regulates cell fate decisions in bone marrow progenitors.
Organism:
Mus musculus
Type:
Expression profiling by array, transformed count, 2 genotype/variation sets
Platform:
GPL6246
Series:
GSE55227
4 Samples
Download data: CEL
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