GEO DataSets

Analysis of clonal isolates collected from three patients with cystic fibrosis (CF). The isolates were collected between 3 months to 8 years after colonization, representing upwards of 39,000 in vivo generations. Results provide insight into the molecular basis of long-term infection of CF lung.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 4 individual, 19 isolate, 3 other, 4 time sets

Platform:

GPL84

Series:

GSE21966

38 Samples

Download data: CEL

Analysis of Pseudomonas aeruginosa PAO1 cells deficient for the transcription factor PA2449. Results provide insight into the role of PA2449 in the metabolism and physiology of Pseudomonas.

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL84

Series:

GSE39044

8 Samples

Download data: CEL

Analysis of P. aeruginosa sphR null mutants grown in media containing lung surfactant. P. aeruginosa is an opportunistic pathogen of the human lung. SphR is an AraC-family transcription factor. Results provide insight into the role of sphR in P. aeruginosa infections in the lung.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:

GPL84

Series:

GSE48982

8 Samples

Download data: CEL

Analysis of P. aeruginosa grown in media containing lung surfactant. P. aeruginosa is a common environmental bacterium that is also an opportunistic pathogen, particularly of the human lung. Results provide insight into the mechanisms used by P. aeruginosa to establish and maintain lung infections.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL84

Series:

GSE48982

4 Samples

Download data: CEL

Analysis of P. aeruginosa strains isolated from chronically-infected lungs of cystic fibrosis (CF) patients, burn wounds, and a burn wound strain infected-murine tumor model. Results provide insight into the molecular mechanisms underlying chronic biofilm-associated P. aeruginosa infections.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 4 isolate, 2 other, 5 strain sets

Platform:

GPL84

Series:

GSE25945

26 Samples

Download data: CEL

Analysis of three different P. aeruginosa strains isolated from burn wound patients and the same strains using two infection models (a plant model and a murine tumor model). Results provide insight into the molecular mechanisms underlying P. aeruginosa infections.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 5 isolate, 3 strain sets

Platform:

GPL84

Series:

GSE23007

30 Samples

Download data: CEL

Analysis of laboratory strain PAO1 treated with 125μM protoanemonin (4-methylenebut-2-en-4-olide), a natural quorum sensing (QS) inhibitor. Results provide insight into the molecular mechanisms underlying protoanemonin inhibition of QS in P. aeruginosa.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL84

Series:

GSE27674

4 Samples

Download data: CEL

Analysis of Pseudomonas aeruginosa PAO1 mucoid kinB mutant and nonmucoid kinB rpoN double mutant. Deletion of the sensor kinase KinB results in alginate overproduction, a trait associated with chronic endobronchial infections in cystic fibrosis. Sigma Factor RpoN is required for mucoid induction.

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL84

Series:

GSE35248

6 Samples

Download data: CEL, CHP

Analysis of Pseudomonas aeruginosa UCBPP-PA14 grown on artificial-sputum medium (ASMDM), MOPS-glucose medium and Luria broth; early exponential and stationary phases. ASMDM mimics cystic fibrosis lung environment.

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa UCBPP-PA14

Type:

Expression profiling by array, transformed count, 3 growth protocol, 2 time sets

Platform:

GPL84

Series:

GSE18594

8 Samples

Download data: CEL, CHP

Analysis of Pseudomonas aeruginosa PA01 (ATCC 15692) Small Colony Variant (SCV). SCVs are slow-growing bacteria that often show increased resistance to antibiotics and cause infection. Results provide insight into mechanisms governing acquisition and reversion of antibiotic resistance in bacteria.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 2 genotype/variation, 2 time sets

Platform:

GPL84

Series:

GSE34141

12 Samples

Download data: CEL

Analysis of Pseduomonas aeruginosa PAO1 treated with colistin at a subinhibitory concentration (0.15 ug/ml). Colistin is an antimicrobial peptide against P. aeruginosa infection in cystic fibrosis lungs. Result provide insight into the adaptive response of P. aeruginosa to low doses of colistin.

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array, count, 2 agent sets

Platform:

GPL84

Series:

GSE13252

6 Samples

Download data: CEL, CHP

Analysis of PAO1 cultures exposed to up to 2.0 ug/ml of the macrolide azithromycin (AZM) for 9 hours. Low-dose macrolides are effective therapy in patients with chronic lung infections such as those caused by P. aeruginosa. Results provide insight into mechanism of action of AZM against infection.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, count, 2 agent, 3 dose sets

Platform:

GPL84

Series:

GSE12738

5 Samples

Download data: CEL

Analysis of PA14 biofilms grown on cystic fibrosis bronchial epithelial (CFBE) cells and PA14 planktonic cultures treated with tobramycin, a CF antibiotic treatment. Results provide insight into P14 infection in the context of CFBEs and suggest P14's response to tobramycin is growth mode-dependent.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, count, 2 agent, 2 cell type sets

Platform:

GPL84

Series:

GSE10030

10 Samples

Download data: CEL, CHP

Analysis of a non-mucoid Pseudomonas aeruginosa strain and a mucoid strain from a cystic fibrosis (CF) patient. P. aeruginosa is an opportunistic pathogen associated with chronic pulmonary infections in CF patients. Non-mucoidity is associated with early stages of CF, mucoidity with late stages.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, count, 2 strain sets

Platform:

GPL84

Series:

GSE9621

4 Samples

Download data: CEL, CHP, EXP

Analysis of Pseudomonas aeruginosa strain PAO1 grown with 2% or 0.4% oxygen (O2), or without O2 but with nitrate instead. In cystic fibrosis (CF) lungs, PAO1 grows to high densities in mucopurulent material depleted in O2. Results provide insight into mode of growth in CF lungs.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, count, 4 dose, 3 stress sets

Platform:

GPL84

Series:

GSE6741

8 Samples

Download data: CEL

Analysis of Pseudomonas aeruginosa E601 grown in media containing various sources of sulfur. P. aeruginosa E601 is a cystic fibrosis isolate that exhibits mucin sulfatase activity. Results provide insight into the pathways that respond to the nature of the supply of sulfur.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, transformed count, 5 growth protocol, 2 strain sets

Platform:

GPL84

Series:

GSE8408

20 Samples

Download data: CEL

Analysis of Pseudomonas aeruginosa isolates from sputa of cystic fibrosis (CF) lungs following growth in minimal media. P. aeruginosa infected CF lungs are characterized by high cell density (HCD) replication of this pathogen. Results provide insight into the mechanisms sustaining HCD replication.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, count, 4 growth protocol, 2 protocol, 3 specimen sets

Platform:

GPL84

Series:

GSE7704

14 Samples

Download data: CEL, CHP

Analysis of Pseudomonas aeruginosa cells treated for up to 20 hours with 3,4-(di)hydroxy-heptyl-quinoline (PQS), a bacterial intercellular signaling molecule. Results provide insight into the role of PQS in the bacterial communication system termed quorum sensing.

Organism:

Pseudomonas aeruginosa; Pseudomonas aeruginosa PAO1

Type:

Expression profiling by array, count, 2 agent, 3 time sets

Platform:

GPL84

Series:

GSE3836

12 Samples

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Analysis of Pseudomonas aeruginosa PAO1 or Type III secretion system (TTSS), rhamnolipid synthesis double mutant strain exposed to cultured airway epithelia. TTSS is a virulence factor in acute infections. Strains from chronic infections express decreased levels of TTSS or lack a functional TTSS.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, count, 2 agent, 2 strain sets

Platform:

GPL84

Series:

GSE4614

8 Samples

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Analysis of cells subjected to elevated copper (Cu) for 45 minutes (Cu shock) or grown in the presence of elevated Cu for 6 hours (Cu adapted). Industrial activity results in elevated levels of environmental Cu. Results provide insight into the molecular response of P. aeruginosa to Cu stress.

Organism:

Pseudomonas aeruginosa

Type:

Expression profiling by array, count, 2 protocol, 4 stress sets

Platform:

GPL84

Series:

GSE4152

8 Samples

Download data