GEO DataSets

Analysis of astrocytes treated with Rho kinase (ROCK) inhibitor fasudil for up to 24 hrs. ROCK inhibitors inhibit glial scarring, a reactive process involving astrogliosis that occurs after injury to CNS. Results provide mechanistic insights into beneficial action of fasudil during brain injury.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 4 time sets

Platform:

GPL6885

Series:

GSE25829

32 Samples

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Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL6885

Series:

GSE71868

8 Samples

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Analysis of thyroid from normal BALB/c adults 24 hours after injection in the tail vein with 13, 130, or 260 kBq of radioactive iodine (131I). The absorbed doses to thyroid were 0.85, 8.5, or 17 Gy. Results provide insight into dose-specific molecular responses of thyroid after 131I administration.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 dose sets

Platform:

GPL6885

Series:

GSE54594

4 Samples

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Analysis of MEFs treated for 24hrs with ligands lipopolysaccharide (LPS), lymphotoxin-β receptor agonist antibody (LTβR), and LPS+ LTβR. Results provide insight into molecular mechanisms underlying a potentially synergistic effect of LTβR signaling on LPS-TLR4 signaling.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 protocol sets

Platform:

GPL6885

Series:

GSE62301

4 Samples

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Analysis of BMDMs primed with IFNγ and subsequently activated with LPS. Pro-inflammatory macrophages are induced by the Th1 cytokine IFNγ and/or the toll-like receptor ligand LPS. Results provide insight into the molecular effects of IFNγ priming on LPS-induced inflammation in macrophages.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 3 protocol sets

Platform:

GPL6885

Series:

GSE60290

15 Samples

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Analysis of developing white adipose tissues (WAT) of C57BL/6 animals at ages 15.5 embyronic days to 12 postnatal days. Results provide insight into the molecular mechanisms underlying the regulation of WAT development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 8 age sets

Platform:

GPL6885

Series:

GSE29502

8 Samples

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Analysis of brain cortices, cerebella, and hippocampi of progranulin (GRN) deficient mutants at ages 2, 6, and 9 months. GRN mutations cause frontotemporal dementia. Results provide insight into the function of GRN in the central nervous system.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 age, 2 gender, 3 genotype/variation, 3 tissue sets

Platform:

GPL6885

Series:

GSE31840

99 Samples

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Analysis of liver from 4-week old C57BL/6 males with hepatocyte-specific deletion of TGFβ-activated kinase 1 (TAK1). In hepatocytes, TAK1 controls activation of both IKK/NF-κB and JNK pathways. Results provide insight into the role of TAK1 in liver pathophysiology.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6885

Series:

GSE51962

4 Samples

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Temporal analysis of left ventricle myocardium from the MCM model of cardiomyopathy. Transient cardiomyopathy develops in this model after 5 day exposure to tamoxifen, with peak heart failure (HF) at day 10, and resolved HF at day 28. Results provide insight into the molecular basis of evolving HF.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 disease state, 5 protocol, 5 time sets

Platform:

GPL6885

Series:

GSE54681

19 Samples

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Analysis of lung from cigarette smoke (CS)-treated C57BL/6N females at 4 and 6 months of age. Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD). Results provide insight into the molecular mechanisms underlying cigarette smoke-induced COPD.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 stress sets

Platform:

GPL6885

Series:

GSE52509

12 Samples

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Analysis of liver from C57Bl/6J males fed isocaloric diets containing sucrose or palatinose. Sucrose is a high glycemic index (GI) sugar; palatinose is a low GI sugar. Results provide insight into molecular mechanisms underlying the role of sucrose in the development of non-alcoholic fatty liver.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol sets

Platform:

GPL6885

Series:

GSE54723

14 Samples

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Analysis of DBC1-knockout splenic B cells following anti-CD40 activation. The deleted in breast cancer 1 (DBC1) gene was initially identified as part of the 8p22 chromosome region that is deleted in breast cancer. Results provide insight into the role of DBC1 in B cell function.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation, 4 protocol sets

Platform:

GPL6885

Series:

GSE61029

8 Samples

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Analysis of intestinal epithelial cells (IECs) from gnotobiotic animals selectively colonized with Bacteroides uniformis or Clostridia. Results provide insight into the role of microbial interactions with IECs in protecting against sensitization to food allergens.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 protocol sets

Platform:

GPL6885

Series:

GSE60039

8 Samples

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Analysis of bone marrow-derived macrophages (BMMs) collected from 6-8 week old C57BL/6 animals and treated with receptor activator of NF-κB ligand (RANKL) for up to 3 days. Results provide insight into the molecular mechanisms underlying RANKL-mediated induction of osteoclastogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 4 time sets

Platform:

GPL6885

Series:

GSE57468

8 Samples

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Analysis of kidney tumors from Lin28a transgenics at 5 weeks and 4 months of age. Overexpression of heterochronic regulator Lin28 during kidney development promotes Wilms tumor formation. Results provide insight into the role of Lin28 in Wilms tumor formation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 disease state sets

Platform:

GPL6885

Series:

GSE56323

8 Samples

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Analysis 3T3 fibroblast cells overexpressing the pluripotency factor DPPA4. DPPA4 encodes a DNA binding SAP domain-containing protein. Results provide insight into the role of DPPA4 in oncogenesis.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 4 agent sets

Platform:

GPL6885

Series:

GSE58709

8 Samples

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Analysis of colon and intestine cells with ectopic Nanog protein expression. Aggressive tumor progression and poor patient diagnosis have been associated with Nanog expression in different types of tumors. Results provide insight into the role of Nanog in tumor initiation.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 protocol, 2 tissue sets

Platform:

GPL6885

Series:

GSE31413

8 Samples

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Analysis of C2C12 cells cultured for up to 3 days in differentiation medium containing ethanol. Chronic alcoholics suffer from weakness and locomotor difficulty resulting from muscle damage. Results provide insight into the signaling pathways affected by ethanol in differentiating myoblasts.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 4 time sets

Platform:

GPL6885

Series:

GSE46492

24 Samples

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Analysis of heart left ventricles from mutants lacking the B subunit of negative elongation factor (NELF). NELF is a regulator of RNA polymerase II pausing. Results provide insight into the role of NELF in myocardial function.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL6885

Series:

GSE54372

6 Samples

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Analysis of forebrain from male and female E12.5 embryos heterozygous for the Meis1tm1Mtor allele. These animals express only one functional allele of Meis1, modeling the reduced expression of MEIS1 in Restless Legs Syndrome (RLS) patients. Results provide insight the role of MEIS1 in RLS.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 gender, 3 genotype/variation sets

Platform:

GPL6885

Series:

GSE44592

16 Samples

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