GEO DataSets

(Submitter supplied) Many heavy metals, including nickel (Ni), cadmium (Cd), and chromium (Cr) are toxic industrial chemicals with an exposure risk in both occupational and environmental settings that may cause harmful outcomes. While these substances are known to produce adverse health effects leading to disease or health problems, the detailed mechanisms remain unclear. To elucidate the processes involved in the of toxicity of nickel, cadmium, and chromium at the molecular level and to perform a comparative analysis, H4-II-E-C3 rat liver-derived cell lines were treated with soluble salts of each metal using concentrations derived from viability assays, and gene expression patterns were determined with DNA microarrays. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3928

Platform:

GPL1355

44 Samples

Download data: CEL

Analysis of H4-II-E-C3 liver-derived cells exposed to toxic heavy metals: nickel II chloride (NiCl2), cadmium chloride (CdCl2), or sodium dichromate (Na2Cr2O7), at various concentrations (based on viability assays). Results provide insight into molecular mechanisms underlying Ni, Cd and Cr toxicity.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, transformed count, 4 agent, 10 dose sets

Platform:

GPL1355

Series:

GSE31503

44 Samples

Download data: CEL