GEO DataSet Links for BioProject (Select 137189) - GEO DataSets

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Items: 2

Select item 2000273091.

SIRT3 opposes metabolic reprogramming of cancer cells through HIF1a destabilization

(Submitter supplied) Tumor cells exhibit aberrant metabolism characterized by high glycolysis even in the presence of oxygen. This metabolic reprogramming, known as the Warburg effect, provides tumor cells with the substrates and redox potential required for the generation of biomass. Here, we show that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect. SIRT3 loss promotes a metabolic profile consistent with high glycolysis required for anabolic processes in vivo and in vitro. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4058
Platform:: GPL1261
10 Samples

Download data: CEL

Series

Accession:: GSE27309

ID:: 200027309

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 40582.

SIRT3 knockout effect on brown adipose tissue

Analysis of brown adipose tissue of sirtuin SIRT3 knockout 129Sv males. SIRT3 is a crucial regulator of the Warburg effect, a metabolic reprogramming that provides tumor cells with the substrates required for biomass generation. Results provide insight into the role of SIRT3 in tumorigenesis.