GEO DataSets

(Submitter supplied) We have previously demonstrated that bone marrow-derived DC can prevent diabetes development and halt progression of insulitis in NOD mice, the mouse model of type 1 diabetes (T1D). The DC population that was most effective in this therapy had a mature phenotype, expressed high levels of costimulatory molecules and secreted low levels of IL-12p70. The protective DC therapy induced regulatory Th2 cells that shifted the dominant Th1 environment, present in NOD mice, to a mixed Th1/Th2 milieu. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4017

Platform:

GPL81

15 Samples

Download data: CEL, CHP

Analysis of therapeutic-GM4 and nontherapeutic-GM bone marrow-derived NOD dendritic cells (DC) up to 20 hrs after activation with LPS + IFN-gamma. The GM4 DC population is able to prevent diabetes in NOD mice. Results provide insight into the molecular basis of the therapeutic effect of GM4 DC.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 agent, 2 cell type, 3 time sets

Platform:

GPL81

Series:

GSE15320

15 Samples

Download data: CEL, CHP