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Macrophage response to silica nanoparticles

(Submitter supplied) Using a macrophage cell line, we demonstrate the ability of amorphous silica particles to stimulate inflammatory protein secretion and induce cytotoxicity. Whole genome microarray analysis of early gene expression changes induced by 10nm and 500nm particles showed that the magnitude of change for the majority of genes correlated more tightly with particle surface area than either particle mass or number. more...
Organism:
Mus musculus
Type:
Expression profiling by array
Platform:
GPL8321
21 Samples
Download data: CEL
Series
Accession:
GSE13005
ID:
200013005

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