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Items: 1 to 20 of 23

1.

RNA interactome profiling in hypervirulent Klebsiella pneumoniae reveals small RNA ArcZ as an inhibitor of mucoviscosity and virulence

(Submitter supplied) Hypervirulent Klebsiella pneumoniae (HvKP) is an emerging human pathogen causing invasive infection in immune-competent hosts. The hypervirulence is strongly linked to the overproduction of hypermucovisous capsule, but the underlining regulatory mechanism of hypermucoviscosity (HMV) has been elusive, especially at the post-transcriptional level mediated by small RNAs (sRNAs). Using a recently developed RNA interactome profiling approach, we have investigated the Hfq-associated sRNA regulatory network and established the first in vivo RNA-RNA interactome in HvKP. more...
Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Type:
Expression profiling by high throughput sequencing
Platform:
GPL33764
14 Samples
Download data: TXT
Series
Accession:
GSE260738
ID:
200260738
2.

RNA interactome profiling in hypervirulent Klebsiella pneumoniae

(Submitter supplied) To map the Hfq-mediated RNA regulatory network in HvKP, we harnessed the LiRIP-seq approach recently established in our lab, which enabled global profiling of RNA-RNA interactomes in live bacteria. Transformation of the pBAD-t4rnl1 plasmid into Klebsiella allowed us to express T4 RNA ligase 1 for proximity-ligation of RNAs in vivo, followed by co-immunoprecipitation (coIP) to enrich the Hfq-bound RNA transcripts (singleton reads) and ligated RNA fragments (chimeras: sRNA-mRNA, sRNA-sRNA, etc).
Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Type:
Other
Platform:
GPL33764
6 Samples
Download data: TXT
Series
Accession:
GSE243246
ID:
200243246
3.

Illumina NovaSeq 6000 (Klebsiella pneumoniae subsp. pneumoniae ATCC 43816)

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
2 Series
20 Samples
Download data
Platform
Accession:
GPL33764
ID:
100033764
4.

mlaA_mutant-pJV300-3

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123323
ID:
308123323
5.

mlaA_mutant-pJV300-1

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123322
ID:
308123322
6.

arcZ_mutant-ArcZ_M5-3

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123321
ID:
308123321
7.

arcZ_mutant-ArcZ_M5-2

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123320
ID:
308123320
8.

arcZ_mutant-ArcZ_M5-1

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123319
ID:
308123319
9.

arcZ_mutant-ArcZ-3

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123318
ID:
308123318
10.

arcZ_mutant-ArcZ-2

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123317
ID:
308123317
11.

arcZ_mutant-ArcZ-1

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123316
ID:
308123316
12.

arcZ_mutant-pJV300-3

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123315
ID:
308123315
13.

arcZ_mutant-pJV300-2

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123314
ID:
308123314
14.

arcZ_mutant-pJV300-1

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123313
ID:
308123313
15.

WT-pJV300-3

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123312
ID:
308123312
16.

WT-pJV300-2

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123311
ID:
308123311
17.

WT-pJV300-1

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE260738
Download data
Sample
Accession:
GSM8123310
ID:
308123310
18.

IgG-3

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE243246
Download data
Sample
Accession:
GSM7781804
ID:
307781804
19.

IgG-2

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE243246
Download data
Sample
Accession:
GSM7781803
ID:
307781803
20.

IgG-1

Organism:
Klebsiella pneumoniae subsp. pneumoniae ATCC 43816
Source name:
Bacterial cells
Platform:
GPL33764
Series:
GSE243246
Download data
Sample
Accession:
GSM7781802
ID:
307781802
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