GSM995475[Accession] - GEO DataSets

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Items: 3

Select item 2000405151.

Expression data from IRE1a or XBP1 deficient mouse liver

(Submitter supplied) IRE1a and XBP1 are key regulators of the unfolded protein response (UPR). XBP1 ablation causes profound hypolipidemia in mice, and triggers feedback activation of its upstream enzyme IRE1a, instigating regulated IRE1-dependent decay (RIDD), an mRNA degradation mechanism dependent on IRE1a's endoribonuclease activity. Comprehensive microarray analysis of XBP1 and/or IRE1a deficient liver identified genes involved in lipogenesis and lipoprotein metabolism as RIDD substrates, which might contribute to the suppression of plasma lipid levels by activated IRE1a.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL11180
31 Samples

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Accession:: GSE40515

ID:: 200040515

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000111802.

[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Protocol: see manufacturer's web site