GSM992502[Accession] - GEO DataSets

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Items: 4

Select item 2000403771.

Microarray profiling of WT or PDE10A KO mice treated with vehicle or a PDE10 inhibitor

(Submitter supplied) Inhibition of phosphodiesterase 10A (PDE10A) promotes cyclic nucleotide signaling, increases striatal activation, and decreases behavioral activity. Enhanced cyclic nucleotide signaling is a well established route to producing changes in gene expression. We hypothesized that chronic suppression of PDE10A activity would have significant effects on gene expression in the striatum. A comparison of the expression profile of PDE10A knockout (KO) mice and wild-type mice after chronic PDE10A inhibition revealed altered expression of 19 overlapping genes with few significant changes outside the striatum or after administration of a PDE10A inhibitor to KO animals. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4542
Platform:: GPL1261
42 Samples

Download data: CEL

Series

Accession:: GSE40377

ID:: 200040377

Select item 45422.

Chronic suppression of phosphodiesterase 10A effect on striatum and hippocampus

Analysis of C57BL6 striatum and hippocampus following chronic inhibition of PDE10A activity by dosing with PDE10A inhibitor TP-10 or by PDE10A knockout. PDE10A transcripts are significantly downregulated in Huntington's disease (HD) brain. Results provide insight into the molecular basis of HD.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation, 2 tissue sets

Platform:: GPL1261
Series:: GSE40377
42 Samples

Download data: CEL

DataSet

Accession:: GDS4542

ID:: 4542

Select item 1000012613.

[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...