GEO DataSets

(Submitter supplied) Deletions and amplifications of the human genomic sequence (Copy Number Polymorphisms, or 'CNPs') are the cause for numerous diseases and a potential cause of phenotypic variation in the normal population. Comparative Genomic Hybridization (CGH) has been developed as a useful tool for detecting alterations in DNA copy number that involve blocks of DNA several kilobases or greater in size. We have developed High-Resolution CGH (HR-CGH) to detect accurately and with relatively little bias the presence and extent of chromosomal aberrations in human DNA. more...

Organism:

Homo sapiens

Type:

Genome variation profiling by genome tiling array

Platforms:

GPL3449 GPL3448 GPL3450

16 Samples

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(Submitter supplied) Maskless array synthesis [1] was used to construct isothermal arrays. This array contains oligonucleotides that start every 85 bp and tiles the entire nonrepetitive part of human chromosome 22 (human genome build NCBI35/hg17 was utilized). Repetitive elements were identified using RepeatMasker [2] and oligonucleotide probes were designed to represent the nonrepetitive DNA sequence. The oligonucleotides were designed to be of variable length, adjusted to match a target melting temperature of 76°C according to the following formula: Tm = 81.5 + 16.6*(log10([Na+])) + 0.41*(%GC) - 600/length. more...

Organism:

Homo sapiens

4 Series

24 Samples

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